Evidence map›Paper›PMID 35705214›Full record

ArticleInternational journal of spine surgery2022

Bone Morphogenetic Protein in Anterior Lumbar Interbody Fusions: A Propensity-Matched Medicare Outcome Analysis.

Syed I Khalid, Ravi S Nunna, Rachyl M Shanker, Kyle B Thomson, Rown Parola, Owoicho Adogwa, Ankit I Mehta

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of spine surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Syed I KhalidDepartment of Neurosurgery, University of Illinois at Chicago, Chicago, IL, USA syed.khalid@me.com.
Ravi S NunnaDepartment of Neurosurgery, University of Illinois at Chicago, Chicago, IL, USA.
Rachyl M ShankerChicago Medical School, North Chicago, IL, USA.
Kyle B ThomsonChicago Medical School, North Chicago, IL, USA.
Rown ParolaDepartment of Neurosurgery, University of Illinois at Chicago, Chicago, IL, USA.
Owoicho AdogwaDepartment of Neurosurgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ankit I MehtaDepartment of Neurosurgery, University of Illinois at Chicago, Chicago, IL, USA.
University of Illinois Chicago · USRosalind Franklin University of Medicine and Science · USThe University of Texas Southwestern Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBone morphogenetic protein (BMP) is a costly agent commonly used in spine surgery. Its effectiveness and complication profile have never been studied in a large, propensity-matched population following its approval by the Food and Drug Administration for use in single-level anterior lumbar interbody fusion (ALIF) surgeries.

objectiveTo investigate the rate of symptomatic pseudarthrosis or need for revision surgery after single-level stand-alone ALIFs with and without the use of BMP.

methodsMedicare Standard Analytic files derived from Medicare parts A and B were used to identify adult patients who underwent single-level ALIF procedures with and without use of BMP between 2004 and 2014. Patients were propensity matched based on their age, gender, and history of diabetes mellitus, hypertension, chronic kidney disease, body mass index greater than 30 kg/m

resultsThe propensity-matched population analyzed in this study contained 22,380 patients undergoing single-level ALIF (8971 [40.6%] with BMP and 13,139 [59.4%] without BMP). Both patient groups were balanced at baseline. The rate of symptomatic pseudarthrosis in the propensity-matched analysis was higher in the BMP group (1.9% vs 1.4%,

conclusionsBMP use in single-level ALIFs may be associated with increased risk of symptomatic pseudarthrosis. Large prospective pragmatic trials are needed to corroborate our findings. LEVEL OF EVIDENCE: 3:

Indexed as

bone morphogenetic proteincomplication, postoperativefusionlumbarpseudarthrosis

Identifiers

PMID35705214
PMCPMC9421204
OpenAlexW4282959967

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.