SynthesisEuropean respiratory review : an official journal of the European Respiratory Society2022
Risk factors for asthma exacerbations during pregnancy: a systematic review and meta-analysis.
Synthesis in European respiratory review : an official journal of the European Respiratory Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 5 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Prenatal exposure to asthma medications and risk of neurodevelopmental disorders and educational difficulties: A systematic review and meta-analysis.PLoS medicine · 2026Pooled it
- Association between adverse childhood experiences and asthma: a meta-analysis.BMC public health · 2026Pooled it
- Maternal asthma during pregnancy and risks of allergy and asthma in progeny: A systematic review and meta-analysis.BJOG : an international journal of obstetrics and gynaecology · 2025Pooled it
- Obesity and asthma during pregnancy: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Geographic pattern of asthma prevalence in Brazilian adolescents: a systematic review with meta-analysis.Jornal de pediatriaPooled it
- How Pregnancy Affects Asthma in Korea: Risk Factors and Adherence Decline.Allergy, asthma & immunology research · 2026Article
- Asthma Medication Adherence and Exacerbations in Pregnancy: Bridging the Gap Between Evidence and Practice.Allergy, asthma & immunology research · 2026Article
- Asthma management in pregnancy and lactation: A review of current evidence and best practice recommendations.NPJ primary care respiratory medicine · 2026Review
- Pregnancy, asthma and exacerbations: a population-based cohort.The European respiratory journal · 2025Article
- Breathing for Two: Asthma Management, Treatment, and Safety of Pharmacological Therapy during Pregnancy.Medicines (Basel, Switzerland) · 2024Review
- Sex differences in asthma control, lung function and exacerbations: the ATLANTIS study.BMJ open respiratory research · 2024Observational
- Chinese expert consensus on the diagnosis, treatment, and management of asthma in women across life.Journal of thoracic disease · 2024Review
- Treatable Traits in Pregnant Women with Asthma.Respiration; international review of thoracic diseases · 2024Review
- Non-allergic factors that influence asthma control in pregnancy.European journal of midwifery · 2024Article
- Treatable traits in asthma during pregnancy: a call for a shift towards a precision-based management approach.European respiratory review : an official journal of the European Respiratory Society · 2023Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConflicting literature exists regarding the risk factors for exacerbations among pregnant women with asthma. This systematic review and meta-analysis aimed to determine risk factors for asthma exacerbations during pregnancy.
methodsElectronic databases were searched for the following terms: (asthma or wheeze) and (pregnan* or perinat* or obstet*) and (exacerb* or flare up or morbidit* or attack*).All studies published between 2000 and 24 August 2021 were considered for inclusion if they reported at least one potential risk factor of asthma exacerbations in pregnant women with asthma. Of the 3337 references considered, 35 publications involving 429 583 pregnant women with asthma were included. Meta-analyses were conducted to determine mean difference in risk factor between exacerbation groups, or the relative risks of exacerbation with certain risk factors. Good study quality was found through the Newcastle-Ottawa Scale (median score 8, interquartile range 7-9).
resultsIncreased maternal age (mean difference 0.62, 95% CI 0.11-1.13), obesity (relative risk 1.25, 95% CI 1.15-1.37), smoking (relative risk 1.35, 95% CI 1.04-1.75), black ethnicity (relative risk 1.62, 95% CI 1.52-1.73), multiparity (relative risk 1.31, 95% CI 1.01-1.68), depression/anxiety (relative risk 1.42, 95% CI 1.27-1.59), moderate-severe asthma (relative risk 3.44, 95% CI 2.03-5.83,
conclusionsFuture interventions aimed at reducing exacerbations in pregnancy could address the modifiable factors, such as smoking and depression/anxiety, and introduce more regular monitoring for those with nonmodifiable risk factors such as obesity and more severe asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.