ArticleCell reports2022
TRPV6 channel mediates alcohol-induced gut barrier dysfunction and systemic response.
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Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Emerging biotechnological approaches in alcoholic liver disease: natural compounds, delivery systems, and translational potential.Science China. Life sciences · 2026Review
- Integrating gut‑brain axis insights into bundled nutrition care for critically ill patients: From mechanisms to implementation (Review).Molecular medicine reports · 2026Review
- Alcohol and Hypertension-A Fresh Look on the Mechanistic Aspects of a Fatal Epidemiologic Relationship.Biomolecules · 2026Review
- Lactiplantibacillus plantarum DS1073 protects the gastric mucosa under Helicobacter pylori infection and ethanol stress.Cell communication and signaling : CCS · 2026Article
- Gut microbiome and bile acid metabolism in liver disease: Mechanisms, clinical implications, and therapeutic opportunities.Pharmacological reviews · 2026Review
- TRPV6-related pancreatitis: natural history and the impact of the pancreas-specific deletion on pancreatitis in mice.Journal of gastroenterology · 2026Article
- Reduced SNHG16 promotes sepsis-induced intestinal injury via the miR-15a-5p/AKT3 axis.BMC gastroenterology · 2026Article
- Nanoemulsion based on natural components enables oral liver-targeting delivery of Schizandrol B to enhance liver regeneration after hepatectomy in hepatocellular carcinoma.Regenerative biomaterials · 2026Article
- Transient receptor melastatin channel in colorectal cancer: pathophysiological mechanisms and a promising drug target.Cancer chemotherapy and pharmacology · 2025Review
- New developments on the effects of alcohol use on immunity, inflammation and organ function: A summary of the 2024 Alcohol and Immunology Research Interest Group (AIRIG) meeting.Alcohol (Fayetteville, N.Y.) · 2025Article
- L-Theanine Mitigates Chronic Alcoholic Intestinal Injury by Regulating Intestinal Alcohol and Linoleic-Arachidonic Acid Metabolism in Rats.Nutrients · 2025Article
- Article
- Dysbiosis and extraintestinal cancers.Journal of experimental & clinical cancer research : CR · 2025Review
- Intestinal Epithelial Tight Junction Barrier Regulation by Novel Pathways.Inflammatory bowel diseases · 2025Review
- Gut‑liver axis in liver disease: From basic science to clinical treatment (Review).Molecular medicine reports · 2025Review
- Alcohol-induced gut microbial reorganization and associated overproduction of phenylacetylglutamine promotes cardiovascular disease.Nature communications · 2024Article
- Gut-liver axis: Recent concepts in pathophysiology in alcohol-associated liver disease.Hepatology (Baltimore, Md.) · 2024Review
- Regulation Mechanism and Potential Value of Active Substances in Spices in Alcohol-Liver-Intestine Axis Health.International journal of molecular sciences · 2024Review
- TRPV6 Channel Is Involved in Pancreatic Ductal Adenocarcinoma Aggressiveness and Resistance to Chemotherapeutics.Cancers · 2023Article
- Review
Corrections and comments
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Authors and funding
17 authors at 2 institutions in 1 country.
Avtar S MeenaDepartments of Physiology, Medicine, Molecular Biology Immunology & Biochemistry, and Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Pradeep K ShuklaDepartments of Physiology, Medicine, Molecular Biology Immunology & Biochemistry, and Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Briar BellDepartments of Physiology, Medicine, Molecular Biology Immunology & Biochemistry, and Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Francesco GiorgianniDepartments of Physiology, Medicine, Molecular Biology Immunology & Biochemistry, and Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Rebeca CairesDepartments of Physiology, Medicine, Molecular Biology Immunology & Biochemistry, and Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Carlos Fernández-PeñaDepartments of Physiology, Medicine, Molecular Biology Immunology & Biochemistry, and Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Sarka BeranovaDepartments of Physiology, Medicine, Molecular Biology Immunology & Biochemistry, and Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Eitaro AiharaDepartment of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati, OH 45221, USA.
Marshall H MontroseDepartment of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati, OH 45221, USA.
Mehdi ChaibDepartments of Physiology, Medicine, Molecular Biology Immunology & Biochemistry, and Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Liza MakowskiDepartments of Physiology, Medicine, Molecular Biology Immunology & Biochemistry, and Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Indira NeeliDepartments of Physiology, Medicine, Molecular Biology Immunology & Biochemistry, and Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Marko Z RadicDepartments of Physiology, Medicine, Molecular Biology Immunology & Biochemistry, and Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Valeria VásquezDepartments of Physiology, Medicine, Molecular Biology Immunology & Biochemistry, and Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Jonathan H JaggarDepartments of Physiology, Medicine, Molecular Biology Immunology & Biochemistry, and Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Julio F Cordero-MoralesDepartments of Physiology, Medicine, Molecular Biology Immunology & Biochemistry, and Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address: jcordero@uthsc.edu.
RadhaKrishna RaoDepartments of Physiology, Medicine, Molecular Biology Immunology & Biochemistry, and Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Memphis Veterans Affairs Medical Center, Memphis, TN 38104, USA. Electronic address: rrao2@uthsc.edu.
University of Tennessee Health Science Center · USUniversity of Cincinnati · US
Funding
INTESTINAL MUCOSAL PROTECTION BY EPIDERMAL GROWTH FACTORR01DK055532 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI RAO, RADHAKRISHNA · 1998 to 2020
$4.7MMECHANISM OF ENDOTOXIN ABSORPTION IN ALCOHOLISMR01AA012307 · NIAAA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI RAO, RADHAKRISHNA · 2000 to 2014
$3.9MSK3 channel trafficking in endothelial cellsR01HL158846 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JAGGAR, JONATHAN H · 2021 to 2024
$2.5MDefining the Role of Intestinal Calcium Channels in Alcoholic Liver Damage.R01AA029270 · NIAAA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI RADHAKRISHNA RAO · 2022 to 2026
$2.5MPKD proteins in endothelial cellsR01HL155180 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JAGGAR, JONATHAN H · 2021 to 2024
$2.4MEndothelial cell potassium channelsR01HL137745 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JAGGAR, JONATHAN H · 2017 to 2020
$2.0MRegulation of mechanosensitive ion channels by membrane lipidsR01GM133845 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI VASQUEZ, VALERIA · 2019 to 2023
$1.9MBlood pressure regulation by smooth muscle cell ion channelsR01HL133256 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JAGGAR, JONATHAN H · 2017 to 2020
$1.5MThe Role of Bioactive Lipids in Transient Receptor Potential Channels GatingR01GM125629 · NIGMS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI CORDERO-MORALES, JULIO F · 2018 to 2022
$1.5MImpact of Stress on Alcoholic Gut InjuryI01BX003014 · VA · MEMPHIS VA MEDICAL CENTER · PI RADHAKRISHNA RAO · 2017 to 2026
–BLRD VA I01 BX003014NHLBI NIH HHS R01 HL133256NHLBI NIH HHS R01 HL137745NHLBI NIH HHS R01 HL155180NHLBI NIH HHS R01 HL158846NIAAA NIH HHS R01 AA012307NIAAA NIH HHS R01 AA029270NIDDK NIH HHS R01 DK055532NIGMS NIH HHS R01 GM125629NIGMS NIH HHS R01 GM133845
Abstract
Intestinal epithelial tight junction disruption is a primary contributing factor in alcohol-associated endotoxemia, systemic inflammation, and multiple organ damage. Ethanol and acetaldehyde disrupt tight junctions by elevating intracellular Ca
Indexed as
EndotoxemiaEthanolHistidineIntestinal MucosaTRPV Cation ChannelsAcetaldehydeAnimalsCaco-2 CellsCalcium ChannelsHumansMiceAcetaldehydeCalcium ChannelsEthanolHistidineTRPV6 channelTRPV6 protein, humanTrpv6 protein, mouseTRPV Cation Channelsalcoholalcohol-binding sitecalciumCP: Cell biologyCP: Immunologyendotoxemiaintestineliverneuroinflammationsystemic inflammationtight junctionTRPV
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.