ArticleCell reports2022
Hebbian activity-dependent plasticity in white matter.
Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Comparative Effectiveness of Noninvasive Brain-Computer Interface-Based Interventions for Upper Limb Rehabilitation in Poststroke Hemiplegia: Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.Journal of medical Internet research · 2026Pooled it
- Efficacy of Brain-Computer Interface Therapy for Upper Limb Rehabilitation in Chronic Stroke: Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of medical Internet research · 2026Pooled it
- The effect of rehabilitation training based on brain-computer interface on limb function in stroke patients: a systematic review and meta-analyses.Frontiers in neurologyPooled it
- Pathway-dependent brain stimulation responses indicate motion processing integrity after stroke.Brain : a journal of neurology · 2025Trial
- Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks.Nature neuroscience · 2026Article
- Spasticity and Abnormal Tone Regulation After Spinal Cord Injury: Mechanisms and the Effects of Neuromodulation.Biomedicines · 2026Review
- Computational origins of cortical brain circuits for social cognition.Nature reviews. Neuroscience · 2026Review
- Network-based analysis of differential white matter connectivity in major depressive disorder with and without comorbid anxiety.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Exploring cortical excitability modulation to promote cognitive resilience in aging: an rTMS study protocol.Frontiers in human neuroscience · 2026Article
- The pulvinar regulates plasticity in human visual cortex.Science advances · 2025Article
- Circuit-Based Approaches to Understanding the Anterior Cingulate Cortex (ACC).The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Promoting motor recovery after stroke using cortico-cortical paired associative stimulation.EClinicalMedicine · 2025Review
- Geometric constraints on the architecture of mammalian cortical connectomes.bioRxiv : the preprint server for biology · 2025Article
- Cerebellar Activity Affects Distal Cortical Physiology and Synaptic Plasticity in a Human Parietal-Motor Pathway Associated with Motor Actions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Repeated spaced paired-associative stimulation to the parietal-motor pathway maintains corticomotor excitability in older adults.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- Linking neuron-axon-synapse architecture to white matter vasculature using high-resolution multimodal MRI in primate brain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- What can neuroimaging of neuromodulation reveal about the basis of circuit therapies for psychiatry?Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- The mouse motor system contains multiple premotor areas and partially follows human organizational principles.Cell reports · 2024Article
- The Use of Transcranial Magnetic Stimulation in Attention Optimization Research: A Review from Basic Theory to Findings in Attention-Deficit/Hyperactivity Disorder and Depression.Life (Basel, Switzerland) · 2024Review
- Obesity is associated with alterations in anatomical connectivity of frontal-corpus callosum.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Synaptic plasticity is required for learning and follows Hebb's rule, the computational principle underpinning associative learning. In recent years, a complementary type of brain plasticity has been identified in myelinated axons, which make up the majority of brain's white matter. Like synaptic plasticity, myelin plasticity is required for learning, but it is unclear whether it is Hebbian or whether it follows different rules. Here, we provide evidence that white matter plasticity operates following Hebb's rule in humans. Across two experiments, we find that co-stimulating cortical areas to induce Hebbian plasticity leads to relative increases in cortical excitability and associated increases in a myelin marker within the stimulated fiber bundle. We conclude that Hebbian plasticity extends beyond synaptic changes and can be observed in human white matter fibers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.