ArticleCell reports2022
Unravelling the sex-specific diversity and functions of adrenal gland macrophages.
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Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 44 citations in OpenAlex.
- IFN-γ-producing self-reactive CD4+ T cells induce autoimmune adrenalitis in a mouse model of Addison's disease.JCI insight · 2026Article
- Adrenal rather than central dysfunction limits hypothalamic-pituitary-adrenal axis recovery after chronic glucocorticoid treatment in male mice.Endocrinology · 2026Article
- Depletion and replacement of tissue-resident macrophages in mice with germ-line deletion of a conserved enhancer in the Csf1r locus.Development (Cambridge, England) · 2026Article
- Adrenal Gland Macrophage-derived TGF-β Governs Vascular Permeability to Drive Monocyte Recruitment during Stress.bioRxiv : the preprint server for biology · 2026Article
- Modulation of alveolar macrophages by sex as a biological variable.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- Adrenal Remodeling and Dysfunction Parallel Age-Dependent Hypertension in Spontaneously Hypertensive Rats.Journal of the American Heart Association · 2026Article
- Macrophage regulation of hypothalamic-pituitary-adrenal and gonadal axis homeostasis and hormonal output.Biomedical journal · 2026Review
- Adipose-Tissue Macrophage Diversity and Functions.International journal of molecular sciences · 2026Review
- Computational tracking of cell origins using CellSexID from single-cell transcriptomes.Cell reports methods · 2025Article
- Addressing Sex as a Biological Variable in Preclinical Models of Lung Disease: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2025Article
- Identification of conserved and tissue-restricted transcriptional profiles for lipid associated macrophages.Communications biology · 2025Article
- Article
- Lipid metabolism in the adrenal gland.Frontiers in endocrinology · 2025Review
- Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutation.PLoS genetics · 2025Article
- Mouse and human macrophages and their roles in cardiovascular health and disease.Nature cardiovascular research · 2024Review
- Glucose metabolism controls monocyte homeostasis and migration but has no impact on atherosclerosis development in mice.Nature communications · 2024Article
- Sex-specific phenotypical, functional and metabolic profiles of human term placenta macrophages.Biology of sex differences · 2024Article
- Identification of conserved and tissue-restricted transcriptional profiles for lipid associated macrophages (LAMs).bioRxiv : the preprint server for biology · 2024Article
- The immunology of sickness metabolism.Cellular & molecular immunology · 2024Review
- Role of sex as a biological variable in neonatal alveolar macrophages.Redox biology · 2024Article
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Authors and funding
34 authors at 13 institutions in 7 countries.
Bastien DolfiUniversité Côte d'Azur, INSERM, C3M, Nice, France; Université Côte d'Azur, CNRS, LP2M, Nice, France.
Alexandre GallerandUniversité Côte d'Azur, INSERM, C3M, Nice, France; Université Côte d'Azur, CNRS, LP2M, Nice, France.
Maria M FirulyovaComputer Technologies Department, ITMO University, Saint Petersburg, Russia.
Yingzheng XuCenter for Immunology, Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA.
Johanna MerlinUniversité Côte d'Azur, INSERM, C3M, Nice, France.
Adélie DumontUniversité Côte d'Azur, INSERM, C3M, Nice, France.
Alexia CastiglioneUniversité Côte d'Azur, INSERM, C3M, Nice, France.
Nathalie VaillantUniversité Côte d'Azur, INSERM, C3M, Nice, France.
Sandrine QuemenerUniv.Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1011-EGID, 59000 Lille, France.
Heidi GerkeTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland.
Marion I StunaultUniversité Côte d'Azur, INSERM, C3M, Nice, France.
Patricia R SchrankCenter for Immunology, Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA.
Seung-Hyeon KimDepartment of Pharmacology and Regenerative Medicine, University of Illinois College of Medicine, Chicago, IL, USA.
Alisha ZhuCenter for Immunology, Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA.
Jie DingDepartment of Pharmacology and Regenerative Medicine, University of Illinois College of Medicine, Chicago, IL, USA.
Jerome GilleronUniversité Côte d'Azur, INSERM, C3M, Nice, France.
Virginie MagnoneUniversité Côte d'Azur, CNRS, IPMC, Valbonne, France.
Pascal BarbryUniversité Côte d'Azur, CNRS, IPMC, Valbonne, France.
David DombrowiczUniv.Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1011-EGID, 59000 Lille, France.
Christophe DurantonUniversité Côte d'Azur, CNRS, LP2M, Nice, France.
Abdelilah WakkachUniversité Côte d'Azur, CNRS, LP2M, Nice, France.
Claudine Blin-WakkachUniversité Côte d'Azur, CNRS, LP2M, Nice, France.
Burkhard BecherInstitute of Experimental Immunology, University of Zürich, Switzerland.
Sophie PagnottaUniversité Côte d'Azur, Centre Commun de Microscopie Appliquée (CCMA), Parc Valrose, 06108 Nice, France.
Rafael J ArgüelloAix Marseille Université, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France.
Pia RantakariTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland.
Svetoslav ChakarovShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Florent GinhouxShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A(∗)STAR), Singapore 138648, Singapore; Department of Microbiology and Immunology, Immunology Translational Research Program, Yong Loo Lin School of Medicine, Immunology Program, Life Sciences Institute, National University of Singapore, Singapore 117543, Singapore; Translational Immunology Institute, SingHealth Duke-NUS Academic Medical Centre, Singapore 169856, Singapore.
Konstantin ZaitsevComputer Technologies Department, ITMO University, Saint Petersburg, Russia.
Ki-Wook KimDepartment of Pharmacology and Regenerative Medicine, University of Illinois College of Medicine, Chicago, IL, USA.
Laurent Yvan-CharvetUniversité Côte d'Azur, INSERM, C3M, Nice, France.
Rodolphe R GuinamardUniversité Côte d'Azur, INSERM, C3M, Nice, France; Université Côte d'Azur, CNRS, LP2M, Nice, France.
Jesse W WilliamsCenter for Immunology, Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA. Electronic address: jww@umn.edu.
Stoyan IvanovUniversité Côte d'Azur, INSERM, C3M, Nice, France; Université Côte d'Azur, CNRS, LP2M, Nice, France. Electronic address: stoyan.ivanov@unice.fr.
Université Côte d'Azur · FRInserm · FRUniversity of Minnesota Medical Center · USLaboratoire de PhysioMédecine Moléculaire · FRUniversity of Illinois Chicago · USCentre National de la Recherche Scientifique · FRITMO University · RUÅbo Akademi University · FICentre Hospitalier Universitaire de Lille · FRNational University of Singapore · SGShanghai Jiao Tong University · CNUniversity of Turku · FIUniversity of Zurich · CH
Funding
Sex and stress hormones control adrenal gland macrophage development and function"R01AI165553 · NIAID · UNIVERSITY OF MINNESOTA · PI WILLIAMS, JESSE WARREN · 2022 to 2025
$2.2MRole of membrane-associated macrophages in health and inflammationR01DK126753 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KIM, KIWOOK · 2021 to 2025
$2.1MATHEROSCLEROTIC LESION INITIATION BY RESIDENT AORTIC MACROPHAGE PROLIFERATIONR00HL138163 · NHLBI · UNIVERSITY OF MINNESOTA · PI WILLIAMS, JESSE WARREN · 2019 to 2021
$747kATHEROSCLEROTIC LESION INITIATION BY RESIDENT AORTIC MACROPHAGE PROLIFERATION AND LIPID UPTAKEK99HL138163 · NHLBI · WASHINGTON UNIVERSITY · PI WILLIAMS, JESSE WARREN · 2018 to 2018
$125kNHLBI NIH HHS K99 HL138163NHLBI NIH HHS R00 HL138163NIAID NIH HHS R01 AI165553NIDDK NIH HHS R01 DK126753
Abstract
Despite the ubiquitous function of macrophages across the body, the diversity, origin, and function of adrenal gland macrophages remain largely unknown. We define the heterogeneity of adrenal gland immune cells using single-cell RNA sequencing and use genetic models to explore the developmental mechanisms yielding macrophage diversity. We define populations of monocyte-derived and embryonically seeded adrenal gland macrophages and identify a female-specific subset with low major histocompatibility complex (MHC) class II expression. In adulthood, monocyte recruitment dominates adrenal gland macrophage maintenance in female mice. Adrenal gland macrophage sub-tissular distribution follows a sex-dimorphic pattern, with MHC class II
Indexed as
Adrenal GlandsMacrophagesMonocytesSex CharacteristicsAnimalsFemaleHistocompatibility Antigens Class IILeukocyte CountMaleMiceHistocompatibility Antigens Class IIadrenal glandCP: Immunologymacrophagemonocytesex dimorphism
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