Evidence map›Paper›PMID 35705034›Full record

ArticleCell reports2022

Genetic encoding of an esophageal motor circuit.

Tatiana C Coverdell, Ruei-Jen Abraham-Fan, Chen Wu, Stephen B G Abbott, John N Campbell

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
  5. Review
  6. Review
  7. Molecular Organization of Autonomic, Respiratory, and Spinally-Projecting Neurons in the Mouse Ventrolateral Medulla.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  8. Brainstem DbhNature · 2024
    Article
  9. Article
  10. Development and regeneration of the vagus nerve.Seminars in cell & developmental biology · 2024
    Review
  11. Article
  12. Molecular cell types as functional units of the efferent vagus nerve.Seminars in cell & developmental biology · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Tatiana C CoverdellBiomedical Sciences Graduate Program, University of Virginia, Charlottesville, VA 22903, USA; Department of Biology, University of Virginia, Charlottesville, VA 22903, USA; Department of Pharmacology, University of Virginia, Charlottesville, VA 22903, USA.
Ruei-Jen Abraham-FanDepartment of Biology, University of Virginia, Charlottesville, VA 22903, USA.
Chen WuBeth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Stephen B G AbbottDepartment of Pharmacology, University of Virginia, Charlottesville, VA 22903, USA.
John N CampbellDepartment of Biology, University of Virginia, Charlottesville, VA 22903, USA. Electronic address: jnc4e@virginia.edu.
University of Virginia · USBeth Israel Deaconess Medical Center · US

Funding

Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KAHN, BARBARA B. · 2000 to 2019
$31.4M
Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI CORKEY, BARBARA E. · 1992 to 2021
$25.0M
TRAINING IN THE PHARMACOLOGICAL SCIENCEST32GM007055 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI LYNCH, KEVIN R. · 1985 to 2022
$7.2M
Molecular and Functional Taxonomy of Cardiovagal NeuronsR01HL153916 · NHLBI · UNIVERSITY OF VIRGINIA · PI CAMPBELL, JOHN NELSON · 2021 to 2025
$3.1M
Role of presympathetic neurons of the hindbrain in cardiovascular controlR01HL148004 · NHLBI · UNIVERSITY OF VIRGINIA · PI ABBOTT, STEPHEN · 2019 to 2023
$2.6M
Genetic Dissection of Nucleus Ambiguus Neurons Controlling Cardiorespiratory FunctionsF31HL158187 · NHLBI · UNIVERSITY OF VIRGINIA · PI COVERDELL, TATIANA CLARISSA · 2021 to 2022
$46k
NHLBI NIH HHS F31 HL158187NHLBI NIH HHS R01 HL148004NHLBI NIH HHS R01 HL153916NIDDK NIH HHS P30 DK046200NIDDK NIH HHS P30 DK057521NIGMS NIH HHS T32 GM007055
6 · The paper itself

Abstract

Motor control of the striated esophagus originates in the nucleus ambiguus (nAmb), a vagal motor nucleus that also contains upper airway motor neurons and parasympathetic preganglionic neurons for the heart and lungs. We disambiguate nAmb neurons based on their genome-wide expression profiles, efferent circuitry, and ability to control esophageal muscles. Our single-cell RNA sequencing analysis predicts three molecularly distinct nAmb neuron subtypes and annotates them by subtype-specific marker genes: Crhr2, Vipr2, and Adcyap1. Mapping the axon projections of the nAmb neuron subtypes reveals that Crhr2

Indexed as

Medulla OblongataVagus NerveHeart RateMotor NeuronsMuscle, SmoothCP: Neuroscienceesophaguslarynxmedullamotor neuronnucleus ambiguusparasympatheticpharynxsingle-cell RNA-seqswallowingvagus nerve

Identifiers

PMID35705034
PMCPMC9255432
OpenAlexW4282925145

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.