Evidence map›Paper›PMID 35705027›Full record

ArticleCell reports2022

Receptor editing constrains development of phosphatidyl choline-specific B cells in V

Alexandra N Worth, Victoria L Palmer, N Max Schabla, Greg A Perry, Anna N Fraser-Philbin, Patrick C Swanson

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Alexandra N WorthDepartment of Medical Microbiology and Immunology, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA.
Victoria L PalmerDepartment of Medical Microbiology and Immunology, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA.
N Max SchablaDepartment of Medical Microbiology and Immunology, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA; Shoreline Biosciences, San Diego, CA 92121, USA.
Greg A PerryDepartment of Medical Microbiology and Immunology, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA.
Anna N Fraser-PhilbinDepartment of Medical Microbiology and Immunology, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA.
Patrick C SwansonDepartment of Medical Microbiology and Immunology, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA. Electronic address: pswanson@creighton.edu.
Creighton University · US

Funding

CONSTRUCTION OF RESEARCH FACILITYC06RR017417 · NCRR · CREIGHTON UNIVERSITY · PI WILSON, M. ROY · 2002 to 2002
$2.0M
Role of VprBP in B cell development and V(D)J recombinationR01GM102487 · NIGMS · CREIGHTON UNIVERSITY · PI SWANSON, PATRICK C. · 2012 to 2015
$1.2M
Replacing an Animal Resource Facility Cage Washer.G20RR024001 · NCRR · CREIGHTON UNIVERSITY · PI DRESCHER, KRISTEN · 2007 to 2007
$638k
Implications of B10-like cell expansion in a model of impaired receptor editingR21AI119829 · NIAID · CREIGHTON UNIVERSITY · PI SWANSON, PATRICK C. · 2017 to 2018
$400k
A novel form of light chain gene replacementR21AI159127 · NIAID · CREIGHTON UNIVERSITY · PI SWANSON, PATRICK C. · 2021 to 2022
$400k
Typhoon 9140S10RR027352 · NCRR · CREIGHTON UNIVERSITY · PI SWANSON, PATRICK C. · 2010 to 2010
$143k
NCRR NIH HHS C06 RR017417NCRR NIH HHS G20 RR024001NCRR NIH HHS S10 RR027352NIAID NIH HHS R21 AI119829NIAID NIH HHS R21 AI159127NIGMS NIH HHS R01 GM102487
6 · The paper itself

Abstract

B1 B cells reactive to phosphatidyl choline (PtC) exhibit restricted immunoglobulin heavy chain (HC) and light chain (LC) combinations, exemplified by V

Indexed as

Immunoglobulin Variable RegionPhosphatidylcholinesAnimalsB-LymphocytesMiceMice, TransgenicSpleenImmunoglobulin Variable RegionPhosphatidylcholinesautoantibodyB cell selectionCD5(+) B cellsCP: Immunologymurine light chainphosphatidyl cholinereceptor editingrepertoire sequencingRep-seq

Identifiers

PMID35705027
PMCPMC9716649
OpenAlexW4282838610

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.