ArticleImmunity2022
Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication.
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Article in Immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
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87citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
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Who cites it
87 citing papers in PubMed, 109 citations in OpenAlex.
- Cobalt-mediated suppression of IFN-γ-JAK-STAT1 signaling reprograms IDO1-driven immunosuppression for metalloimmunotherapy.Science advances · 2026Article
- Peri-weaning, diet-induced activation of an IFNγ-mediated regulatory circuit promotes cDC1 maturation and CD8Nature communications · 2026Article
- Integrating host-microbiota metabolic networks: how aromatic amino acids shape immune homeostasis and affect disease progression.Cellular & molecular immunology · 2026Review
- Machine learning-based identification of a metabolic cell death gene signature for assessing disease activity and immunological landscape in inflammatory bowel disease.Scientific reports · 2026Article
- The DC1 conundrum: Do type I dendritic cells make or break allograft tolerance?American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Review
- Cell Signaling by Tryptophan Catabolism.Biochemistry · 2026Review
- Plasma metabolomics reveals distinct metabolic alterations and biomarkers of disease activity in HLA-B27-positive acute anterior uveitis.Eye (London, England) · 2026Article
- Intestinal Microfold Cells Play a Critical Role in the Uptake and Oral Tolerance Mediated by Lysophosphatidylserine-Containing Lipidic Nanoparticles.Nanomaterials (Basel, Switzerland) · 2026Article
- Identification of alterations of immunometabolism associated with Pompe disease.Cellular and molecular life sciences : CMLS · 2026Article
- NADAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Tumor-activated dual metabolic nanomodulator turns over tolerogenic tumor control and unleashes systemic immune responses.Journal of nanobiotechnology · 2026Article
- Lessons from neoadjuvant immunotherapy in melanoma: understanding antitumour immunity and tumour escape.Nature reviews. Immunology · 2026Review
- Article
- IDO family: the metabolic crossroads connecting immunity, nerves and tumors.Journal of translational medicine · 2026Review
- The aryl hydrocarbon receptor: structure, signaling, physiology and pathology.Signal transduction and targeted therapy · 2026Review
- Single-cell RNA sequencing unveils enhanced antitumor immunity in colorectal cancer with PD-1 blockade and LINC00673 deletion.Biomarker research · 2026Article
- Dendritic Cell Organization and Function in Innate and Adaptive Immune Defense Within Lymph Nodes.Immunological reviews · 2026Review
- Reimagining AHR in Cancer: From Environmental Sensor to Novel Immunomodulatory Therapeutic Target.International journal of biological sciences · 2026Review
- From immune desert to hot tumor: the tripartite synergy of tumor microenvironment-exosomes-immunogenic cell death in pioneering solutions.Frontiers in immunology · 2026Review
- The IDO1/AhR-HIF-1α metabolic axis: ARNT competition as a central antagonistic switch in autoimmune pathogenesis.Frontiers in immunology · 2026Review
27 more citing papers are in PubMed but not listed here.
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Authors and funding
30 authors at 7 institutions in 5 countries.
Marco GargaroDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy; Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Giulia ScalisiDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy.
Giorgia ManniDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy.
Carlos G BriseñoDepartment of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Prachi BagadiaDepartment of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Vivek DuraiDepartment of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Derek J TheisenDepartment of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Sunkyung KimDepartment of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Marilena CastelliDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy.
Chenling A XuDepartment of Electrical Engineering & Computer Science, Center for Computational Biology, University of California, Berkeley, CA, USA.
Gerd Meyer Zu HörsteDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
Giuseppe ServilloDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy; University research center in functional genomics (c.u.r.ge.f.), University of Perugia, Perugia, Italy.
Maria A Della FaziaDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy.
Giulia MencarelliDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy.
Doriana RicciutiDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy.
Eleonora PadiglioniDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy.
Nicola GiacchèTES Pharma, Loc. Taverne, Corciano, Italy.
Carolina CollivaTES Pharma, Loc. Taverne, Corciano, Italy.
Roberto PellicciariTES Pharma, Loc. Taverne, Corciano, Italy.
Mario CalvittiDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy.
Teresa ZelanteDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy.
Dietmar FuchsDivision of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria.
Ciriana OrabonaDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy.
Louis BoonBioceros, Utrecht, the Netherlands.
Alban BessedeImmusmol, Bordeaux, France.
Marco ColonnaDepartment of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Paolo PuccettiDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy; University research center in functional genomics (c.u.r.ge.f.), University of Perugia, Perugia, Italy.
Theresa L MurphyDepartment of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Kenneth M MurphyDepartment of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Howard Hughes Medical Institute, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. Electronic address: kmurphy@wustl.edu.
Francesca FallarinoDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy; University research center in functional genomics (c.u.r.ge.f.), University of Perugia, Perugia, Italy. Electronic address: francesca.fallarino@unipg.it.
University of Perugia · ITWashington University in St. Louis · USHoward Hughes Medical Institute · USInnsbruck Medical University · ATPolpharma Biologics (Netherlands) · NLUniversity Hospital Münster · DEUniversity of California, Berkeley · US
Funding
TRAINING PROGRAM IN IMMUNOLOGY AND IMMUNOGENETICST32AI007163 · NIAID · WASHINGTON UNIVERSITY · PI Kenneth M Murphy, Kodi S Ravichandran · 1985 to 2026
$14.8MFunction of Wdfy4 in cross-presentation and immunityR01AI150297 · NIAID · WASHINGTON UNIVERSITY · PI MURPHY, KENNETH M · 2019 to 2023
$2.5MNIAID NIH HHS R01 AI150297NIAID NIH HHS T32 AI007163
Abstract
Conventional dendritic cells (cDCs), cDC1 and cDC2, act both to initiate immunity and maintain self-tolerance. The tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) is used by cDCs in maintaining tolerance, but its role in different subsets remains unclear. At homeostasis, only mature CCR7
Indexed as
Indoleamine-Pyrrole 2,3,-DioxygenaseKynurenineAnimalsDendritic CellsHumansMiceSignal TransductionTryptophanIndoleamine-Pyrrole 2,3,-DioxygenaseKynurenineTryptophanAhRdendritic cellsIDO1IL-6immunotolerancekynureninemetabolitesneuroinflammationRelBtryptophan metabolism
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.