Evidence map›Paper›PMID 35704783›Full record

ArticleHuman vaccines & immunotherapeutics2022

Novel H7N9 influenza immunogen design enhances mobilization of seasonal influenza T cell memory in H3N2 pre-immune mice.

Leonard Moise, Lauren M Meyers, Hyesun Jang, Mayara Grizotte-Lake, Christine M Boyle, Bethany McGonnigal, Pan Ge, Ted M Ross, Anne S De Groot

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Leonard MoiseEpiVax, Inc., Providence, RI, USA.ORCID 0000-0002-4410-865X
Lauren M MeyersEpiVax, Inc., Providence, RI, USA.
Hyesun JangCenter for Vaccines and Immunology, University of Georgia, Athens, GA, USA.
Mayara Grizotte-LakeEpiVax, Inc., Providence, RI, USA.
Christine M BoyleEpiVax, Inc., Providence, RI, USA.
Bethany McGonnigalEpiVax, Inc., Providence, RI, USA.
Pan GeCenter for Vaccines and Immunology, University of Georgia, Athens, GA, USA.
Ted M RossCenter for Vaccines and Immunology, University of Georgia, Athens, GA, USA.ORCID 0000-0003-1947-7469
Anne S De GrootEpiVax, Inc., Providence, RI, USA.ORCID 0000-0001-5911-1459
University of Georgia · USProvidence College · US

Funding

Structure-Guided Design of CD4 T cell Memory-Enhanced rHA H7N9 Influenza VaccineR01AI132205 · NIAID · EPIVAX, INC. · PI DEGROOT, ANNE SEARLS · 2017 to 2021
$5.8M
Development of a Non-adjuvanted VLP Vaccine against Stealth H7N9 InfluenzaR43AI118189 · NIAID · EPIVAX, INC. · PI DEGROOT, ANNE SEARLS · 2016 to 2017
$591k
NIAID NIH HHS R01 AI132205NIAID NIH HHS R43 AI118189
6 · The paper itself

Abstract

Strategies that improve influenza vaccine immunogenicity are critical for the development of vaccines for pandemic preparedness. Hemagglutinin (HA)-specific CD4

Indexed as

Influenza A Virus, H7N9 SubtypeInfluenza, HumanInfluenza VaccinesOrthomyxoviridae InfectionsVaccines, Virus-Like ParticleAnimalsAntibodies, ViralEpitopes, T-LymphocyteHemagglutinin Glycoproteins, Influenza VirusHumansInfluenza A Virus, H3N2 SubtypeMiceSeasonsAntibodies, ViralEpitopes, T-LymphocyteHemagglutinin Glycoproteins, Influenza VirusInfluenza VaccinesVaccines, Virus-Like ParticleH7N9hemagglutininimmunoinformaticsinfluenzaT cellT cell epitopeVaccinevirus-like particle

Identifiers

PMID35704783
PMCPMC9721412
OpenAlexW4282932075

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.