Evidence map›Paper›PMID 35704760›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Mechanism of voltage sensing in Ca

Willy Carrasquel-Ursulaez, Ignacio Segura, Ignacio Díaz-Franulic, Felipe Echeverría, Yenisleidy Lorenzo-Ceballos, Nicolás Espinoza, Maximiliano Rojas, Jose Antonio Garate, Eduardo Perozo, Osvaldo Alvarez and 2 more

Erratum issuedAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Tuning the gate and the gear: The LRRC26 (γ1) subunit modulates intrinsic gating and voltage-sensor coupling of the BK channel.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Tuning the gate and the gear: The LRRC26 (bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Voltage sensors.Molecular pharmacology · 2025
    Review
  7. Article
  8. Review
  9. Large conductance voltage-and calcium-activated KFrontiers in pharmacology · 2024
    Review
  10. Trapping Charge Mechanism in Hv1 Channels (International journal of molecular sciences · 2023
    Article
  11. Fifty years of gating currents and channel gating.The Journal of general physiology · 2023
    Review
  12. CaInternational journal of molecular sciences · 2023
    Review
  13. Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Willy Carrasquel-UrsulaezCentro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2340000, Chile.ORCID 0000-0002-4661-2913
Ignacio SeguraCentro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2340000, Chile.ORCID 0000-0002-9446-7757
Ignacio Díaz-FranulicCentro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2340000, Chile.
Felipe EcheverríaCentro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2340000, Chile.ORCID 0000-0001-6087-201X
Yenisleidy Lorenzo-CeballosCentro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2340000, Chile.
Nicolás EspinozaCentro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2340000, Chile.
Maximiliano RojasCenter for Bioinformatics and Integrative Biology, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago 8370146, Chile.ORCID 0000-0001-5439-0225
Jose Antonio GarateCentro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2340000, Chile.ORCID 0000-0002-8345-968X
Eduardo PerozoDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637.ORCID 0000-0001-7132-2793
Osvaldo AlvarezCentro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2340000, Chile.ORCID 0000-0001-8558-580X
Fernando D Gonzalez-NiloCentro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2340000, Chile.ORCID 0000-0001-6857-3575
Ramón LatorreCentro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2340000, Chile.ORCID 0000-0002-6044-5795

Funding

The Electrophysiological Studies of Voltage Gated ChannelsR01GM030376 · NIGMS · UNIVERSITY OF CHICAGO · PI BEZANILLA, FRANCISCO J · 1985 to 2025
$9.1M
ELECTROPHYSIOLOGICAL STUDIES OF VOLTAGE GATED CHANNELSR37GM030376 · NIGMS · UNIVERSITY OF CHICAGO · PI BEZANILLA, FRANCISCO J · 1999 to 2008
$3.7M
NIGMS NIH HHS R01 GM030376NIGMS NIH HHS R37 GM030376
6 · The paper itself

Abstract

In neurosecretion, allosteric communication between voltage sensors and Ca

Indexed as

Ion Channel GatingLarge-Conductance Calcium-Activated Potassium ChannelsArginineMolecular Dynamics SimulationMutationArginineLarge-Conductance Calcium-Activated Potassium ChannelsallosterismBK channelspotassium channelsvoltage sensitivity

Identifiers

PMID35704760
PMCPMC9231616

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.