Evidence map›Paper›PMID 35704583›Full record

ArticleScience advances2022

Steroid nuclear receptor coactivator 2 controls immune tolerance by promoting induced T

Wencan Zhang, Xu Cao, Xiancai Zhong, Hongmin Wu, Mingye Feng, Yousang Gwack, Noah Isakov, Zuoming Sun

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

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  12. SRC2 controls CD4Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Wencan ZhangDepartment of Immunology and Theranostics, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.ORCID 0000-0002-8828-2000
Xu CaoDepartment of Immuno-Oncology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.ORCID 0000-0002-9927-6802
Xiancai ZhongDepartment of Immunology and Theranostics, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.ORCID 0000-0001-8312-4057
Hongmin WuDepartment of Immunology and Theranostics, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.
Mingye FengDepartment of Immuno-Oncology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.ORCID 0000-0002-3334-9917
Yousang GwackDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-2821-9245
Noah IsakovDepartment of Microbiology, Immunology and Genetics, Ben-Gurion University of Negev, Bear Sheva, Israel.ORCID 0000-0002-1412-0957
Zuoming SunDepartment of Immunology and Theranostics, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.ORCID 0000-0003-1896-6666
City Of Hope National Medical Center · USCity of Hope · USBen-Gurion University of the Negev · ILUniversity of California, Los Angeles · US

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
Steroid nuclear receptor coactivators in T cell differentiationR01AI109644 · NIAID · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Zuoming Sun · 2014 to 2026
$6.9M
Function of TCF-1 in antagonizing malignancyR21AI163256 · NIAID · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI SUN, ZUOMING · 2021 to 2022
$484k
NCI NIH HHS P30 CA033572NIAID NIH HHS R01 AI109644NIAID NIH HHS R21 AI163256
6 · The paper itself

Abstract

Steroid nuclear receptor coactivator 2 (SRC2) is a member of a family of transcription coactivators. While SRC1 inhibits the differentiation of regulatory T cells (T

Identifiers

PMID35704583
PMCPMC9200286
OpenAlexW4282937230

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.