Evidence map›Paper›PMID 35704508›Full record

ArticleJournal of leukocyte biology2022

Circulating IL-6 but not neutrophil extracellular traps levels can predict anakinra effectiveness in patients with severe COVID-19.

Vanessa Granger, Audrey Fels, Thomas Huet, Jean-Louis Laplanche, Sophie Laplanche, Gilles Chatellier, Hélène Beaussier, Sylvie Chollet-Martin, Luc de Chaisemartin, Gilles Hayem

Registry-linked trialAbstract readLetterComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of leukocyte biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04594356 (Assessment of Netosis During COVID-19, Under Treatment With Anakinra, an Interleukin-1 Receptor Antagonist), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04594356 completednot on this map

Assessment of Netosis During COVID-19, Under Treatment With Anakinra, an Interleukin-1 Receptor Antagonist

TypeobservationalSponsorFondation Hôpital Saint-JosephRan2020 to 2023Enrolled120ConditionsCovid19
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Vanessa GrangerImmunology Department, Bichat Hospital, APHP, DMU BIOGéM, Paris, France.
Audrey FelsClinical Research Department, Paris-Saint Joseph Hospital Group, Paris, France.
Thomas HuetRheumatology Department, Paris-Saint Joseph Hospital Group, Paris, France.
Jean-Louis LaplancheBiochemistry & Molecular Biology Department, Saint-Louis Lariboisière and Fernand-Widal Hospital Group, Paris, France.
Sophie LaplancheBiology Department, Paris-Saint Joseph Hospital Group, Paris, France.
Gilles ChatellierClinical Research Department, Paris-Saint Joseph Hospital Group, Paris, France.
Hélène BeaussierClinical Research Department, Paris-Saint Joseph Hospital Group, Paris, France.
Sylvie Chollet-MartinImmunology Department, Bichat Hospital, APHP, DMU BIOGéM, Paris, France.
Luc de ChaisemartinImmunology Department, Bichat Hospital, APHP, DMU BIOGéM, Paris, France.
Gilles HayemRheumatology Department, Paris-Saint Joseph Hospital Group, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Added data on circulating IL-6 levels can predict COVID-19 severity and IL1RA efficiency.

Indexed as

COVID-19 Drug TreatmentExtracellular TrapsHumansInterleukin 1 Receptor Antagonist ProteinInterleukin-6NeutrophilsInterleukin 1 Receptor Antagonist ProteinInterleukin-6

Identifiers

PMID35704508
PMCPMC9349441

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.