Evidence map›Paper›PMID 35704395›Full record

ArticleJournal of neurophysiology2022

Histamine/H1 receptor signaling in the parafacial region increases activity of chemosensitive neurons and respiratory activity in rats.

C R Sobrinho, B M Milla, J Soto-Perez, T S Moreira, D K Mulkey

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

C R SobrinhoDepartment of Physiology and Biophysics, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil.ORCID 0000-0002-1472-7169
B M MillaDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut.ORCID 0000-0002-4362-3879
J Soto-PerezDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut.ORCID 0000-0001-9602-9796
T S MoreiraDepartment of Physiology and Biophysics, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil.
D K MulkeyDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut.ORCID 0000-0002-7040-3927
University of Connecticut · USUniversidade de São Paulo · BR

Funding

Glial chemosensitivity: pH sensing and interactions with neuronal chemoreceptorsR01HL104101 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI MULKEY, DANIEL K, OLSEN, MICHELLE L · 2010 to 2024
$5.5M
Role of KCNQ2 Channels in Control of BreathingR01HL137094 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI MULKEY, DANIEL K, TZINGOUNIS, ANASTASIOS · 2018 to 2025
$4.1M
Proposed roles of KCNQ2 Channels in Respiratory HomeostasisF31HL156470 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI SOTO, JASEPH · 2021 to 2024
$173k
Roles of glycinergic neurons in Dravet syndrome-associated disordered breathing and mortalityF31NS120467 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI MILLA, BRENDA · 2020 to 2024
$166k
HHS | National Institutes of Health (NIH) HL104101HHS | National Institutes of Health (NIH) HL137094HHS | National Institutes of Health (NIH) HL156470HHS | National Institutes of Health (NIH) NS120467NHLBI NIH HHS F31 HL156470NHLBI NIH HHS R01 HL104101NHLBI NIH HHS R01 HL137094NINDS NIH HHS F31 NS120467
6 · The paper itself

Abstract

Histaminergic neurons of the tuberomammillary nucleus (TMN) are pH sensitive and contribute to CO

Indexed as

HistamineReceptors, Histamine H1AnimalsCarbon DioxideChemoreceptor CellsMaleNeuronsRatsRats, WistarRespiratory CenterSerotoninCarbon DioxideHistamineReceptors, Histamine H1SerotoninchemoreceptionGq signalingH1 receptorserotonin

Identifiers

PMID35704395
PMCPMC9448344
OpenAlexW4282942923

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.