Evidence map›Paper›PMID 35704327›Full record

ArticleTranslational vision science & technology2022

An Artificial-Intelligence-Based Automated Grading and Lesions Segmentation System for Myopic Maculopathy Based on Color Fundus Photographs.

Jia Tang, Mingzhen Yuan, Kaibin Tian, Yuelin Wang, Dongyue Wang, Jingyuan Yang, Zhikun Yang, Xixi He, Yan Luo, Ying Li and 7 more

Open access · goldAbstract read
In one paragraph

Article in Translational vision science & technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 5 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 5 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
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  6. Shaping the future of myopia: artificial intelligence for vitreoretinal complications of high and pathologic myopia.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Review
  7. IMI-Instrumentation for Myopia Management.Investigative ophthalmology & visual science · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Jia TangDepartment of Ophthalmology, Peking Union Medical College Hospital, Beijing, China.
Mingzhen YuanDepartment of Ophthalmology, Peking Union Medical College Hospital, Beijing, China.
Kaibin TianAI and Media Computing Lab, School of Information, Renmin University of China, Beijing, China.
Yuelin WangDepartment of Ophthalmology, Peking Union Medical College Hospital, Beijing, China.
Dongyue WangDepartment of Ophthalmology, Peking Union Medical College Hospital, Beijing, China.
Jingyuan YangDepartment of Ophthalmology, Peking Union Medical College Hospital, Beijing, China.
Zhikun YangDepartment of Ophthalmology, Peking Union Medical College Hospital, Beijing, China.
Xixi HeVistel AI Lab, Visionary Intelligence, Beijing, China.
Yan LuoDepartment of Ophthalmology, Peking Union Medical College Hospital, Beijing, China.
Ying LiDepartment of Ophthalmology, Peking Union Medical College Hospital, Beijing, China.
Jie XuBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China.
Xirong LiAI and Media Computing Lab, School of Information, Renmin University of China, Beijing, China.
Dayong DingVistel AI Lab, Visionary Intelligence, Beijing, China.
Yanhan RenChicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
Youxin ChenDepartment of Ophthalmology, Peking Union Medical College Hospital, Beijing, China.
Srinivas R SaddaDoheny Eye Institute, Los Angeles, CA, USA.
Weihong YuDepartment of Ophthalmology, Peking Union Medical College Hospital, Beijing, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNPeking Union Medical College Hospital · CNRenmin University of China · CNCapital Medical University · CNRosalind Franklin University of Medicine and Science · USUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To develop deep learning models based on color fundus photographs that can automatically grade myopic maculopathy, diagnose pathologic myopia, and identify and segment myopia-related lesions. Methods: Photographs were graded and annotated by four ophthalmologists and were then divided into a high-consistency subgroup or a low-consistency subgroup according to the consistency between the results of the graders. ResNet-50 network was used to develop the classification model, and DeepLabv3+ network was used to develop the segmentation model for lesion identification. The two models were then combined to develop the classification-and-segmentation-based co-decision model. Results: This study included 1395 color fundus photographs from 895 patients. The grading accuracy of the co-decision model was 0.9370, and the quadratic-weighted κ coefficient was 0.9651; the co-decision model achieved an area under the receiver operating characteristic curve of 0.9980 in diagnosing pathologic myopia. The photograph-level F1 values of the segmentation model identifying optic disc, peripapillary atrophy, diffuse atrophy, patchy atrophy, and macular atrophy were all >0.95; the pixel-level F1 values for segmenting optic disc and peripapillary atrophy were both >0.9; the pixel-level F1 values for segmenting diffuse atrophy, patchy atrophy, and macular atrophy were all >0.8; and the photograph-level recall/sensitivity for detecting lacquer cracks was 0.9230. Conclusions: The models could accurately and automatically grade myopic maculopathy, diagnose pathologic myopia, and identify and monitor progression of the lesions. Translational Relevance: The models can potentially help with the diagnosis, screening, and follow-up for pathologic myopic in clinical practice.

Indexed as

Macular DegenerationMyopia, DegenerativeRetinal DiseasesAtrophyHumansIntelligenceRetrospective StudiesVision DisordersVisual Acuity

Identifiers

PMID35704327
PMCPMC9206390
OpenAlexW4282963361

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.