ArticleInternational endodontic journal2022
Outcomes reporting in systematic reviews on vital pulp treatment: A scoping review for the development of a core outcome set.
Article in International endodontic journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06780527 (Clinical Performance and Radiographic Assessment of Resin Composite Restoration After Dentin Biomodification by Grape Seed Extract in Vital Teeth With Deep Occlusal Carious Lesions. "18-M Randomized Clinical Trial"), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Performance and Radiographic Assessment of Resin Composite Restoration After Dentin Biomodification by Grape Seed Extract in Vital Teeth With Deep Occlusal Carious Lesions. "18-M Randomized Clinical Trial"
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Premixed calcium silicate-based materials for pulpotomy outcomes in permanent and deciduous teeth: a systematic review and meta-analysis of clinical trials.Clinical oral investigations · 2025Pooled it
- Trial
- The short-term postoperative pain and impact upon quality of life of pulpotomy and root canal treatment, in teeth with symptoms of irreversible pulpitis: A randomized controlled clinical trial.International endodontic journal · 2025Trial
- On the necessity of complete caries excavation: a narrative review.Head & face medicine · 2025Review
- Effectiveness of Diode Lasers as an Adjunct in Pulpotomy Procedures Involving Primary Teeth: A Systematic Review.International journal of clinical pediatric dentistry · 2025Article
- Exploring vital pulp Therapies: A bibliometric analysis of the most cited articles.The Saudi dental journal · 2024Article
- Outcome assessment methods of bioactive and biodegradable materials as pulpotomy agents in primary and permanent teeth: a scoping review.BMC oral health · 2024Article
- Outcomes reporting in systematic reviews on revitalization: A scoping review for the development of a core outcome set.International endodontic journal · 2022Article
- Outcomes reporting in systematic reviews on vital pulp treatment: A scoping review for the development of a core outcome set.International endodontic journal · 2022Article
- Assessment of Pulpal Status in Primary Teeth Following Direct Pulp Capping in an Experimental Canine Model.Diagnostics (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundA large number of research reports on vital pulp treatment (VPT) has been published over the last two decades. However, heterogeneity in reporting outcomes of VPT is a significant challenge for evidence synthesis and clinical decision-making.
objectivesTo identify outcomes assessed in VPT studies and to evaluate how and when outcomes are measured. A subsidiary aim was to assess evidence for selective reporting bias in the included studies. The results of this review will be used to inform the development of a core outcome set (COS) for endodontic treatments.
methodsMultiple healthcare bibliographic databases, including PubMed/MEDLINE, Ovid EMBASE, Scopus, Cochrane Database of Systematic Reviews and Web of Science were searched for systematic reviews published between 1990 and 2020, reporting on VPT. Screening, data extraction and risk of bias assessment were completed independently by two reviewers. Outcomes' information was extracted and aligned with a healthcare taxonomy into five core areas: survival, clinical/physiological changes, life impact, resource use and adverse events.
resultsThirty-six systematic reviews were included, 10 reporting on indirect pulp capping or selective caries removal, nine on direct pulp capping, eight on pulpotomy and nine on combined VPTs. There was considerable variation in the outcomes reported in these reviews and their included studies. Clinician-reported outcomes were used considerably more often than patient-reported outcomes. A range of instruments and time points were used for measuring outcomes. Several of the reviews were assessed as having low risk of selective reporting bias, but many did not specifically report this domain, whilst others did not provide risk of bias assessment at all. DISCUSSION: Considerable variation in selection of outcomes and how and when they are measured and reported was evident, and this heterogeneity has implications for evidence synthesis and clinical decision-making.
conclusionsWhilst there is a lack of consistency, several potentially important outcomes for VPT, including pulp survival, incidence of post-operative pain and need for further intervention, have been identified which could inform the development of a COS for endodontic treatment. REGISTRATION: Core Outcome Measures in Effectiveness Trials (COMET) (No. 1879).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.