Evidence map›Paper›PMID 35704124›Full record

Trial reportAIDS and behavior2022

Real-time Feedback to Improve HIV Treatment Adherence in Pregnant and Postpartum Women in Uganda: A Randomized Controlled Trial.

Lora L Sabin, Elizabeth Simmons, Nafisa Halim, Davidson H Hamer, Allen L Gifford, Rebecca L West, Anna Larson, Rachael Bonawitz, Philip Aroda, Bolanle Banigbe and 6 more

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in AIDS and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02396394 (Improving ART Retention and Adherence in Uganda), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02396394 nacompletednot on this map

Improving ART Retention and Adherence in Uganda: The WiseMama Study

TypeinterventionalSponsorBoston UniversityRan2015 to 2018Enrolled165ConditionsHIVArmsTwo-Step Adherence Feedback
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Lora L SabinDepartment of Global Health, Boston University School of Public Health, 801 Massachusetts Avenue, Crosstown Center, 3rd Floor, 02118, Boston, MA, USA. lsabin@bu.edu.ORCID http://orcid.org/0000-0002-2782-542X
Elizabeth SimmonsDepartment of Global Health, Boston University School of Public Health, 801 Massachusetts Avenue, Crosstown Center, 3rd Floor, 02118, Boston, MA, USA.
Nafisa HalimDepartment of Global Health, Boston University School of Public Health, 801 Massachusetts Avenue, Crosstown Center, 3rd Floor, 02118, Boston, MA, USA.
Davidson H HamerDepartment of Global Health, Boston University School of Public Health, 801 Massachusetts Avenue, Crosstown Center, 3rd Floor, 02118, Boston, MA, USA.
Allen L GiffordDepartment of Medicine, Boston University School of Medicine, 02118, Boston, MA, USA.
Rebecca L WestDepartment of Global Health, Boston University School of Public Health, 801 Massachusetts Avenue, Crosstown Center, 3rd Floor, 02118, Boston, MA, USA.
Anna LarsonDepartment of Global Health, Boston University School of Public Health, 801 Massachusetts Avenue, Crosstown Center, 3rd Floor, 02118, Boston, MA, USA.
Rachael BonawitzDepartment of Global Health, Boston University School of Public Health, 801 Massachusetts Avenue, Crosstown Center, 3rd Floor, 02118, Boston, MA, USA.
Philip ArodaMildmay Uganda, Kampala Road, Kampala, Uganda.
Bolanle BanigbeDepartment of Global Health, Boston University School of Public Health, 801 Massachusetts Avenue, Crosstown Center, 3rd Floor, 02118, Boston, MA, USA.
Alayna J HoldermanDepartment of Human Genetics, University of Pittsburgh School of Public Health, 15261, Pittsburgh, PA, USA.
Lisa MurrayDepartment of Epidemiology & Biostatistics, Boston University School of Public Health, 02118, Boston, MA, USA.
Mary B DeSilvaCenter for Excellence in Public Health, University of New England, 04103, Portland, ME, USA.
Julia GasuzaMildmay Uganda, Kampala Road, Kampala, Uganda.
Barbara MukasaMildmay Uganda, Kampala Road, Kampala, Uganda.
Lisa J MessersmithDepartment of Global Health, Boston University School of Public Health, 801 Massachusetts Avenue, Crosstown Center, 3rd Floor, 02118, Boston, MA, USA.

Funding

Improving ART Retention and Adherence in Uganda, the WiseMama StudyR34MH103075 · NIMH · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MESSERSMITH, LISA JEAN, SABIN, LORA L · 2014 to 2016
$670k
NIH HHS 1R34MN103075NIMH NIH HHS R34 MH103075
6 · The paper itself

Abstract

We assessed an intervention aimed at improving adherence to antiretroviral therapy (ART) among pregnant and postpartum women living with HIV (PPWLH). We randomized 133 pregnant women initiating ART in Uganda to receive text reminders generated by real time-enabled electronic monitors and data-informed counseling through 3 months postpartum (PPM3) or standard care. Intention-to-treat analyses found low adherence levels and no intervention impact. Proportions achieving ≥95% adherence in PPM3 were 16.4% vs. 9.1% (t = -1.14, p = 0.26) in intervention vs. comparison groups, respectively; 30.9% vs. 29.1% achieved ≥80% adherence. Additional analyses found significant adherence declines after delivery, and no effect on disease progression (CD4-cell count, viral load), though treatment interruptions were significantly fewer in intervention participants. Per-protocol analyses encompassing participants who used adherence monitors as designed experienced better outcomes, suggesting potential benefit for some PPWLH. The study was registered on ClinicalTrials.Gov (NCT02396394).

Indexed as

Anti-HIV AgentsHIV InfectionsFeedbackFemaleHumansMedication AdherencePostpartum PeriodPregnancyTreatment Adherence and ComplianceUgandaViral LoadAnti-HIV AgentsHIV treatment adherencePregnant and postpartum womenRandomized controlled trialUganda

Identifiers

PMID35704124
PMCPMC9640413

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.