Evidence map›Paper›PMID 35704103›Full record

ArticleCell and tissue research2022

Proteoglycan 4 is present within the dura mater and produced by mesenchymal progenitor cells.

Sathvika Mudigonda, Sophia Shah, Nabangshu Das, Jessica May Corpuz, Nicoletta Ninkovic, Nedaa Al-Jezani, T Michael Underhill, Paul T Salo, Alim P Mitha, Frank G Lyons and 4 more

Abstract read
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In one paragraph

Article in Cell and tissue research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Sathvika Mudigonda *McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, AB, Canada.
Sophia Shah *McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, AB, Canada.
Nabangshu DasMcCaig Institute for Bone and Joint Health, University of Calgary, Calgary, AB, Canada.
Jessica May CorpuzMcCaig Institute for Bone and Joint Health, University of Calgary, Calgary, AB, Canada.
Nicoletta NinkovicMcCaig Institute for Bone and Joint Health, University of Calgary, Calgary, AB, Canada.
Nedaa Al-JezaniMcCaig Institute for Bone and Joint Health, University of Calgary, Calgary, AB, Canada.
T Michael UnderhillDepartment of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
Paul T SaloMcCaig Institute for Bone and Joint Health, University of Calgary, Calgary, AB, Canada.
Alim P MithaBiomedical Engineering Graduate Program, University of Calgary, Calgary, AB, Canada.
Frank G LyonsDepartment of Surgery, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Roger ChoDepartment of Surgery, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Tannin A SchmidtBiomedical Engineering Department, University of Connecticut Health Center, Farmington, CT, USA.
Antoine DufourMcCaig Institute for Bone and Joint Health, University of Calgary, Calgary, AB, Canada.
Roman J KrawetzMcCaig Institute for Bone and Joint Health, University of Calgary, Calgary, AB, Canada. rkrawetz@ucalgary.ca.ORCID http://orcid.org/0000-0002-2576-4504
University of Calgary · CAUConn Health · USUniversity of British Columbia · CA

Funding

Alberta Spine Foundation Pilot GrantCanadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada Discovery GrantMcCaig Institute Pilot Grant
6 · The paper itself

Abstract

Mesenchymal progenitor cells (MPCs) have been recently identified in human and murine epidural fat and have been hypothesized to contribute to the maintenance/repair/regeneration of the dura mater. MPCs can secrete proteoglycan 4 (PRG4/lubricin), and this protein can regulate tissue homeostasis through bio-lubrication and immunomodulatory functions. MPC lineage tracing reporter mice (Hic1) and human epidural fat MPCs were used to determine if PRG4 is expressed by these cells in vivo. PRG4 expression co-localized with Hic1

Indexed as

Mesenchymal Stem CellsAnimalsDura MaterHumansMiceProteoglycan 4ProteoglycansPRG4 protein, humanPrg4 protein, mouseProteoglycan 4ProteoglycansDuraEpidural fatMesenchymal progenitor cellsProteoglycan 4

Identifiers

PMID35704103
OpenAlexW4282938059

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.