Evidence map›Paper›PMID 35704074›Full record

SynthesisEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2022

Symptoms and clinical features in patients affected by endolymphatic sac tumor: a systematic review and meta-analysis.

Federico Maria Gioacchini, Shaniko Kaleci, Giuseppe Chiarella, Pasquale Viola, Davide Pisani, Alfonso Scarpa, Michele Tulli, Annalisa Pace, Giannicola Iannella, Massimo Re

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Federico Maria GioacchiniDepartment of Clinical and Molecular Sciences, ENT Unit, Polytechnic University of Marche, Ancona, Italy. giox83@hotmail.com.ORCID http://orcid.org/0000-0002-1148-4384
Shaniko KaleciDepartment of Diagnostic Medicine, Clinical and Public Health, University Hospital of Modena, Modena, Italy.
Giuseppe ChiarellaUnit of Audiology, Department of Experimental and Clinical Medicine, Regional Centre of Cochlear Implants and ENT Diseases, Magna Graecia University, Catanzaro, Italy.
Pasquale ViolaUnit of Audiology, Department of Experimental and Clinical Medicine, Regional Centre of Cochlear Implants and ENT Diseases, Magna Graecia University, Catanzaro, Italy.
Davide PisaniUnit of Audiology, Department of Experimental and Clinical Medicine, Regional Centre of Cochlear Implants and ENT Diseases, Magna Graecia University, Catanzaro, Italy.
Alfonso ScarpaDepartment of Medicine and Surgery, University of Salerno, Salerno, Italy.
Michele TulliDepartment of Clinical and Molecular Sciences, ENT Unit, Polytechnic University of Marche, Ancona, Italy.
Annalisa PaceDepartment of Sense Organs, Sapienza University Rome, Rome, Italy.
Giannicola IannellaDepartment of Sense Organs, Sapienza University Rome, Rome, Italy.
Massimo ReDepartment of Clinical and Molecular Sciences, ENT Unit, Polytechnic University of Marche, Ancona, Italy.
Magna Graecia University · ITMarche Polytechnic University · ITSapienza University of Rome · ITUniversity of Modena and Reggio Emilia · ITUniversity of Salerno · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMost ELST data in the literature are case studies or limited to small cohorts (< 16 patients). We evaluated the main clinical signs observed at endolymphatic sac tumor (ELST) diagnosis in patients with or without Von Hippel-Lindau disease.

methodsWe conducted a comprehensive literature search in PubMed, Scopus, and Web of Science. We included studies with at least 1 patient, of any age, affected by sporadic or VHL-related ELSTs reporting levels of hearing loss and facial nerve function and a comprehensive description of presenting symptoms at ELST diagnosis. We combined data for proportional meta-analysis. p values of 0.05 were considered statistically significant. Methodological quality was evaluated. Analyses were performed with MedCalc 14.8.1 software.

resultsA total of 26 studies, including 113 patients and 118 cases of ELSTs were included. Pooled proportion rates (95% CI) of overall hearing loss was 88.7%, (82.4-93.4), severe hearing loss was 21.6% (12.8-32.1) profound hearing loss was 39.8% (28.7-51.5), vertigo/imbalance was 42.0% (33.8-50.5), tinnitus was 61.8% (53.4-69.8) and facial nerve palsy was 30.6% (23.2-38.9). Generally, symptoms were homogeneous or moderately heterogeneous among included studies.

conclusionThis is the first systematic review of clinical presentations at ELST diagnosis. The most serious clinical events include profound hearing loss and facial impairment. Fluctuating hearing loss, tinnitus and vertigo are frequently reported and may confound correct and prompt ELST diagnosis.

Indexed as

AdenomaBone NeoplasmsEar NeoplasmsEndolymphatic SacHearing LossLabyrinth DiseasesTinnitusvon Hippel-Lindau DiseaseHumansVertigoEndolymphatic sac tumorHouse–Brackmann grading systemPure tone audiometryVon Hippel-Lindau disease

Identifiers

PMID35704074
OpenAlexW4282933171

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.