Evidence map›Paper›PMID 35704064›Full record

ArticleJournal of molecular evolution2022

Noether's Theorem as a Metaphor for Chargaff's 2nd Parity Rule in Genomics.

Yannis Almirantis, Astero Provata, Wentian Li

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Article in Journal of molecular evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Yannis AlmirantisTheoretical Biology and Computational Genomics Laboratory, Institute of Bioscience and Applications, National Center for Scientific Research "Demokritos", 15341, Athens, Greece. yalmir@bio.demokritos.gr.
Astero ProvataStatistical Mechanics and Dynamical Systems Laboratory, Institute of Nanoscience and Nanotechnology, National Center for Scientific Research, "Demokritos", 15341, Athens, Greece.
Wentian LiThe Robert S. Boas Center for Genomics and Human Genetics, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present note, the genomic compositional rule largely known as 'Chargaff's 2nd parity rule' (asserting equimolarity between Adenine-Thymine and Guanine-Cytosine in any of the two DNA strands) is regarded in association with Noether's theorem linking symmetries with conservation laws in physics. In the case of the genome, the strict physical and mathematical prerequisites of Noether's theorem do not hold. However, we conclude that a metaphor can be established with Noether's theorem, as inter-strand symmetry concerning DNA functionality engenders specific features in genome composition. Inversely, when inter-strand symmetry does not hold, the corresponding quantitative relations fail to appear. This association is also considered from the point of view of the existence of emergent laws and properties in evolutionary genomics.

Indexed as

GenomicsDNAGenomeDNAChargaff’s 2nd parity ruleConservation lawsDNA inter-strand symmetryEmergent laws in evolutionary biologyNoether’s theorem

Identifiers

PMID35704064

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.