ArticleAnnals of medicine2022
A causal relationship between childhood obesity and risk of osteoarthritis: results from a two-sample Mendelian randomization analysis.
Article in Annals of medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 6 of them syntheses that pooled it.
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Who cites it
99 citing papers in PubMed, 6 syntheses or guidelines pooled it, 172 citations in OpenAlex.
- Using Mendelian randomization analyses in osteoarthritis: state of art and future perspectives.Annals of medicine · 2025Pooled it
- Mechanical versus kinematic alignment for total knee arthroplasty: a meta-analysis.Archives of orthopaedic and trauma surgery · 2025Pooled it
- Casual effect of ulcerative colitis on chronic heart failure: results from a bidirectional Mendelian randomization study.BMC gastroenterology · 2025Pooled it
- Functional alignment in robotic-assisted total knee arthroplasty: a systematic review.Archives of orthopaedic and trauma surgery · 2024Pooled it
- Association between gut microbiota and spinal stenosis: a two-sample mendelian randomization study.Frontiers in immunology · 2024Pooled it
- Level I of evidence does not support manual lymphatic drainage for total knee arthroplasty: a meta-analysis.Scientific reports · 2023Pooled it
- How gut microbiome and blood metabolites drive ossification of the posterior longitudinal ligament of the spine: a genome-wide association study based on the East Asian population.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Obesity-Associated Osteoarthritis: Mechanical-Metabolic Pathogenesis, Obesity Memory and Dual-Target Therapy.Current obesity reports · 2026Review
- Using human proteomic and lipidomic to exploration drug target of bladder cancer.World journal of urology · 2026Article
- Causal Association Between Antidepressant Use and Thyroid Disease Risk: A Two-Sample Mendelian Randomization Study.Actas espanolas de psiquiatria · 2026Article
- The gut microbial metabolite 3-indolepropionic acid as a functional neuroprotective agent against intracerebral hemorrhage: integrating epidemiological screening with in vivo validation.Metabolic brain disease · 2026Article
- Article
- Primary biliary cirrhosis and rheumatoid arthritis: a comprehensive study combining genetics and transcriptomics.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Global Burden of Rheumatic Heart Disease (1990-2021), Attributable Risk Factors, and Future Projections.JACC. Basic to translational science · 2026Article
- Causal relationship between chronic kidney disease and senile cataract: a bidirectional two-sample Mendelian randomization study.Molecular and cellular biochemistry · 2026Article
- Brain age gap as biomarker linking cardiovascular diseases genetic susceptibility and causality.iScience · 2026Article
- Kinesiotaping following primary total knee arthroplasty : Alevel I evidence-based meta-analysis.Orthopadie (Heidelberg, Germany) · 2026Review
- The causal relationship between multiple cardiovascular diseases and glioblastoma: A Mendelian randomization study.Medicine · 2026Article
- Age-Related Genetic Causal Association Between Asthma and Delirium: A Bidirectional Two-Sample Mendelian Randomization.Brain and behavior · 2026Article
- Investigating the association between uterine fibroids and weight-bearing joint osteoarthritis based on a bidirectional Mendelian randomization study.Experimental and therapeutic medicine · 2026Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIt has been found that childhood obesity (CO) may play an important role in the onset and progression of osteoarthritis (OA). Thus we conducted this mendelian randomisation analysis (MR) to evaluate the causal association between childhood obesity and osteoarthritis.
methodsInstrumental variables (IVs) were obtained from publicly available genome-wide association study datasets. The leave-one-out sensitivity test, MR Pleiotropy RESidual Sum and Outlier test (MR-PRESSO), and Cochran's
resultsAfter excluding all outliers identified by the MR-PRESSO test, no evident directional pleiotropy was found. Significant heterogeneity was found in the secondary MR and as a result, the multiplicative random-effect model was used. Significant causal association between CO and OA (OR 1.0075, 95% CI [1.0054, 1.0010],
conclusionThere appears to be a causal relationship between childhood obesity and OA. Our results indicate that individuals with a history of childhood obesity require specific clinical attention to prevent the development of knee and hip OA.
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