Evidence map›Paper›PMID 35703914›Full record

ArticleJournal of neuropathology and experimental neurology2022

Targeted Next-Generation Sequencing Reveals Divergent Clonal Evolution in Components of Composite Pleomorphic Xanthoastrocytoma-Ganglioglioma.

Calixto-Hope G Lucas, Christian J Davidson, Mouied Alashari, Angelica R Putnam, Nicholas S Whipple, Carol S Bruggers, Joe S Mendez, Samuel H Cheshier, Jeffrey B Walker, Biswarathan Ramani and 17 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuropathology and experimental neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 4 institutions in 1 country.

Calixto-Hope G LucasFrom the Department of Pathology, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0002-8347-9592
Christian J DavidsonDepartment of Pathology, University of Utah, Salt Lake City, Utah, USA.
Mouied AlashariDivision of Pediatric Pathology, Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
Angelica R PutnamDivision of Pediatric Pathology, Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
Nicholas S WhippleDivision of Pediatric Hematology/Oncology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
Carol S BruggersDivision of Pediatric Hematology/Oncology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
Joe S MendezDepartment of Neurosurgery, University of Utah/Huntsman Cancer Institute, Salt Lake City, Utah, USA.
Samuel H CheshierDivision of Pediatric Neurosurgery, Department of Neurosurgery, Huntsman Cancer Institute, University of Utah, Intermountain Primary Children's Hospital, Salt Lake City, Utah, USA.
Jeffrey B WalkerBoise Pathology Group, St. Luke's, Boise, Idaho, USA.
Biswarathan RamaniFrom the Department of Pathology, University of California, San Francisco, San Francisco, California, USA.
Cathryn R CadwellFrom the Department of Pathology, University of California, San Francisco, San Francisco, California, USA.
Daniel V SullivanFrom the Department of Pathology, University of California, San Francisco, San Francisco, California, USA.
Rufei LuFrom the Department of Pathology, University of California, San Francisco, San Francisco, California, USA.
Kanish MirchiaFrom the Department of Pathology, University of California, San Francisco, San Francisco, California, USA.
Jessica Van ZiffleFrom the Department of Pathology, University of California, San Francisco, San Francisco, California, USA.
Patrick DevineFrom the Department of Pathology, University of California, San Francisco, San Francisco, California, USA.
Ezequiel GoldschmidtDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Shawn L Hervey-JumperDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Nalin GuptaDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Nancy Ann Oberheim BushDivision of Neuro-Oncology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
David R RaleighDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Andrew BollenFrom the Department of Pathology, University of California, San Francisco, San Francisco, California, USA.
Tarik TihanFrom the Department of Pathology, University of California, San Francisco, San Francisco, California, USA.
Melike PekmezciFrom the Department of Pathology, University of California, San Francisco, San Francisco, California, USA.
David A SolomonFrom the Department of Pathology, University of California, San Francisco, San Francisco, California, USA.
Joanna J PhillipsDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Arie PerryDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
University of California, San Francisco · USUniversity of Utah · USPrimary Children's Hospital · USSt. Luke’s Boise Medical Center · US

Funding

Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2002 to 2026
$57.4M
Training Program in Translational Brain Tumor ResearchT32CA151022 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2010 to 2026
$6.6M
Cohesin gene mutations in tumorigenesisDP5OD021403 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SOLOMON, DAVID A. · 2015 to 2019
$2.0M
NCI NIH HHS P50 CA097257NCI NIH HHS T32 CA151022NIH HHS DP5 OD021403
6 · The paper itself

Abstract

Composite pleomorphic xanthoastrocytoma-ganglioglioma (PXA-GG) is an extremely rare central nervous system neoplasm with 2 distinct but intermingled components. Whether this tumor represents a "collision tumor" of separate neoplasms or a monoclonal neoplasm with divergent evolution is poorly understood. Clinicopathologic studies and capture-based next generation sequencing were performed on extracted DNA from all available PXA-GG at 2 medical centers. Five PXA-GG were diagnosed in 1 male and 4 female patients ranging from 13 to 25 years in age. Four arose within the cerebral hemispheres; 1 presented in the cerebellar vermis. DNA was sufficient for analysis in 4 PXA components and 3 GG components. Four paired PXA and GG components harbored BRAF p.V600E hotspot mutations. The 4 sequenced PXA components demonstrated CDKN2A homozygous deletion by sequencing with loss of p16 (protein product of CDKN2A) expression by immunohistochemistry, which was intact in all assessed GG components. The PXA components also demonstrated more frequent copy number alterations relative to paired GG components. In one PXA-GG, shared chromosomal copy number alterations were identified in both components. Our findings support divergent evolution of the PXA and GG components from a common BRAF p.V600E-mutant precursor lesion, with additional acquisition of CDKN2A homozygous deletion in the PXA component as is typically seen in conventional PXA.

Indexed as

AstrocytomaBrain NeoplasmsGangliogliomaAdolescentAdultClonal EvolutionCyclin-Dependent Kinase Inhibitor p16DNAFemaleHigh-Throughput Nucleotide SequencingHomozygoteHumansMaleMutationProto-Oncogene Proteins B-rafSequence DeletionCyclin-Dependent Kinase Inhibitor p16DNAProto-Oncogene Proteins B-rafCollision tumorGangliogliomaIntratumoral heterogeneityMolecular neuropathologyNeurooncologyPleomorphic xanthoastrocytomaPrecision medicine

Identifiers

PMID35703914
PMCPMC9297094
OpenAlexW4282960782

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.