Evidence map›Paper›PMID 35703565›Full record

ArticleJournal of bacteriology2022

The AraC/XylS Protein MxiE and Its Coregulator IpgC Control a Negative Feedback Loop in the Transcriptional Cascade That Regulates Type III Secretion in Shigella flexneri.

Joy A McKenna, Monika M A Karney, Daniel K Chan, Natasha Weatherspoon-Griffin, Brianda Becerra Larios, M Carolina Pilonieta, George P Munson, Helen J Wing

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. A Tale aboutMicroorganisms · 2023
    Review
  6. Toward aInternational journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Joy A McKennaSchool of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, USA.
Monika M A KarneySchool of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, USA.
Daniel K ChanSchool of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, USA.
Natasha Weatherspoon-GriffinSchool of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, USA.
Brianda Becerra LariosSchool of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, USA.
M Carolina PilonietaDepartment of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, Florida, USA.
George P MunsonDepartment of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, Florida, USA.ORCID 0000-0002-3692-8199
Helen J WingSchool of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, USA.ORCID 0000-0003-0123-5568
University of Nevada, Las Vegas · USUniversity of Miami · US

Funding

Outreach/Diversity/Pipeline ProjectP20GM103440 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Julia Petereit · 2012 to 2026
$58.0M
Understanding transcriptional silencing & anti-silencing mechanisms in ShigellaR15AI090573 · NIAID · UNIVERSITY OF NEVADA LAS VEGAS · PI WING, HELEN J · 2010 to 2024
$2.3M
Nevada Space Grant Consortium (NVSGC) NNX15AI02HNIAID NIH HHS R15 AI090573NIGMS NIH HHS P20 GM103440
6 · The paper itself

Abstract

Members of the AraC family of transcriptional regulators (AFTRs) control the expression of many genes important to cellular processes, including virulence. In

Indexed as

Gene Expression Regulation, BacterialShigella flexneriBacterial ProteinsCytarabineDNA-Binding ProteinsFeedbackTranscription, GeneticType III Secretion SystemsVirulence FactorsBacterial ProteinsCytarabineDNA-Binding ProteinsType III Secretion SystemsVirulence FactorsIpgCMxiEnegative AraC-like regulatornegative feedback loopospD1 promoterShigellatype III secretiontype III secretion systemvirB promoterVirF

Identifiers

PMID35703565
PMCPMC9295595
OpenAlexW4282964824

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.