ArticlemSphere2022
The Serological Sciences Network (SeroNet) for COVID-19: Depth and Breadth of Serology Assays and Plans for Assay Harmonization.
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Article in mSphere, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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22citing papers in PubMed, 1 pooled it
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dynamics of SARS-CoV-2 seroassay sensitivity: a systematic review and modelling study.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023Pooled it
- Outpatient COVID-19 convalescent plasma recipient antibody thresholds correlated to reduced hospitalizations within a randomized trial.JCI insight · 2024Trial
- Pre-vaccine sentinel antibodies predict blunted vaccine responses.Cell press blue · 2026Article
- Lack of harmonisation in immunological data: challenges in synthesising data during the COVID-19 pandemic.EBioMedicine · 2026Review
- Article
- A dual-reporter HCoV-OC43 for coronavirus biology and countermeasure development.Antiviral research · 2025Article
- Pregnancy reduces COVID-19 vaccine immunity against novel variants.NPJ vaccines · 2025Article
- In the time of COVID-19: challenges, successes, and lessons learned from studies in cancer patients.Journal of the National Cancer Institute · 2025Article
- SARS-CoV-2 Variant-Specific Antibodies in Vaccinated Inflammatory Bowel Disease Patients.Vaccines · 2025Article
- A third COVID-19 vaccine dose in kidney transplant recipients induces antibody response to vaccine and Omicron variants but shows limited Ig subclass switching.Microbiology spectrum · 2025Article
- Application of machine learning algorithms to identify serological predictors of COVID-19 severity and outcomes.Communications medicine · 2024Article
- The Landscape of Observational COVID-19 Cohort Studies Funded by the National Institute of Allergy and Infectious Diseases.American journal of epidemiology · 2024Article
- Article
- A bead-based multiplex assay covering all coronaviruses pathogenic for humans for sensitive and specific surveillance of SARS-CoV-2 humoral immunity.Scientific reports · 2023Article
- Application of machine learning models to identify serological predictors of COVID-19 severity and outcomes.Research square · 2023Article
- Monoclonal Antibodies as SARS-CoV-2 Serology Standards: Experimental Validation and Broader Implications for Correlates of Protection.International journal of molecular sciences · 2023Article
- Review
- Article
- Three doses of COVID-19 mRNA vaccine induce class-switched antibody responses in inflammatory arthritis patients on immunomodulatory therapies.Frontiers in immunology · 2023Article
- Reconsideration of Antinucleocapsid IgG Antibody as a Marker of SARS-CoV-2 Infection Postvaccination for Mild COVID-19 Patients.Open forum infectious diseases · 2023Article
Corrections and comments
- Update of
Authors and funding
59 authors.
Amy B KargerDepartment of Laboratory Medicine and Pathology, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.ORCID 0000-0002-2781-3824
James D BrienDepartment of Molecular Microbiology & Immunology, Saint Louis Universitygrid.262962.b, St. Louis, Missouri, USA.
Jayne M ChristenFrederick National Laboratory for Cancer Researchgrid.418021.e, Frederick, Maryland, USA.
Santosh DhakalW. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0002-4494-8608
Troy J KempFrederick National Laboratory for Cancer Researchgrid.418021.e, Frederick, Maryland, USA.
Sabra L KleinW. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0002-0730-5224
Ligia A PintoFrederick National Laboratory for Cancer Researchgrid.418021.e, Frederick, Maryland, USA.ORCID 0000-0002-3130-9882
Lakshmanane PremkumarDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.
John D RobackDepartment of Pathology and Laboratory Medicine, grid.471395.dgrid.189967.8Emory University School of Medicinegrid.471395.d, Atlanta, Georgia, USA.
Raquel A BinderDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Karl W BoehmeDepartment of Microbiology & Immunology, University of Arkansas for Medical Sciencesgrid.241054.6, Little Rock, Arkansas, USA.ORCID 0000-0003-2691-9763
Suresh BoppanaDepartment of Pediatrics, University of Alabama at Birminghamgrid.265892.2, Birmingham, Alabama, USA.
Carlos Cordon-CardoDepartment of Pathology, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.
James M CrawfordDepartment of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
John L DaissMicroB-plex, Inc., Atlanta, Georgia, USA.ORCID 0000-0002-9690-7701
Alan P DupuisWadsworth Centergrid.465543.5, New York State Department of Health, Albany, New York, USA.
Ana M EspinoDepartment of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico, USA.ORCID 0000-0001-8456-2550
Adolfo Firpo-BetancourtDepartment of Pathology, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.
Catherine ForconiDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
J Craig ForrestDepartment of Microbiology & Immunology, University of Arkansas for Medical Sciencesgrid.241054.6, Little Rock, Arkansas, USA.
Roxie C GirardinWadsworth Centergrid.465543.5, New York State Department of Health, Albany, New York, USA.
Douglas A GrangerSalimetrics, LLC, Carlsbad, California, USA.
Steve W GrangerSalimetrics, LLC, Carlsbad, California, USA.
Natalie S HaddadDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, grid.471395.dgrid.189967.Emory University, Atlanta, Georgia, USA.
Christopher D HeaneyDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0003-3211-8495
Danielle T HuntWadsworth Centergrid.465543.5, New York State Department of Health, Albany, New York, USA.
Joshua L KennedyDepartment of Pediatrics, University of Arkansas for Medical Sciencesgrid.241054.6, Little Rock, Arkansas, USA.
Christopher L KingDepartment of Pathology, Case Western Reserve School of Medicine, Cleveland, Ohio, USA.
Florian KrammerDepartment of Microbiology, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.ORCID 0000-0003-4121-776X
Kate KruczynskiDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Joshua LaBaerVirginia G. Piper Center for Personalized Diagnostics, Arizona State University Biodesign Institute, Tempe, Arizona, USA.
F Eun-Hyung LeeDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, grid.471395.dgrid.189967.Emory University, Atlanta, Georgia, USA.
William T LeeWadsworth Centergrid.465543.5, New York State Department of Health, Albany, New York, USA.ORCID 0000-0003-2883-0391
Shan-Lu LiuCenter for Retrovirus Research, The Ohio State Universitygrid.261331.4, Columbus, Ohio, USA.
Gerard LozanskiDepartment of Pathology, The Ohio State Universitygrid.261331.4 Medical Center, Columbus, Ohio, USA.
Todd LucasDivision of Public Health, College of Human Medicine, Michigan State University, East Lansing, Michigan, USA.
Damodara Rao MenduDepartment of Pathology, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.
Ann M MoormannDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.ORCID 0000-0003-1113-2829
Vel MuruganVirginia G. Piper Center for Personalized Diagnostics, Arizona State University Biodesign Institute, Tempe, Arizona, USA.
Nkemakonam C OkoyeDepartment of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
Petraleigh PantojaUnit of Comparative Medicine, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico, USA.
Anne F PayneWadsworth Centergrid.465543.5, New York State Department of Health, Albany, New York, USA.
Jin ParkVirginia G. Piper Center for Personalized Diagnostics, Arizona State University Biodesign Institute, Tempe, Arizona, USA.
Swetha PinnintiDepartment of Pediatrics, University of Alabama at Birminghamgrid.265892.2, Birmingham, Alabama, USA.
Amelia K PintoDepartment of Molecular Microbiology & Immunology, Saint Louis Universitygrid.262962.b, St. Louis, Missouri, USA.ORCID 0000-0002-7147-3978
Nora PisanicDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Ji QiuVirginia G. Piper Center for Personalized Diagnostics, Arizona State University Biodesign Institute, Tempe, Arizona, USA.
Carlos A SariolUnit of Comparative Medicine, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico, USA.
Viviana SimonDepartment of Microbiology, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.
Lusheng SongVirginia G. Piper Center for Personalized Diagnostics, Arizona State University Biodesign Institute, Tempe, Arizona, USA.
Tara L SteffenDepartment of Molecular Microbiology & Immunology, Saint Louis Universitygrid.262962.b, St. Louis, Missouri, USA.
E Taylor StoneDepartment of Molecular Microbiology & Immunology, Saint Louis Universitygrid.262962.b, St. Louis, Missouri, USA.
Linda M StyerWadsworth Centergrid.465543.5, New York State Department of Health, Albany, New York, USA.ORCID 0000-0001-8137-0318
Mehul S SutharCenter for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicinegrid.471395.d, Atlanta, Georgia, USA.
Stefani N ThomasDepartment of Laboratory Medicine and Pathology, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.ORCID 0000-0003-1679-5453
Bharat ThyagarajanDepartment of Laboratory Medicine and Pathology, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
Ania WajnbergDepartment of Medicine, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.
Jennifer L YatesWadsworth Centergrid.465543.5, New York State Department of Health, Albany, New York, USA.
Kimia SobhaniDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Centergrid.50956.3f, Los Angeles, California, USA.
Funding
WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6MVirology Resource CoreU54CA260492 · NCI · JOHNS HOPKINS UNIVERSITY · PI KLEIN, SABRA L. · 2020 to 2024
$10.4MProject 3: Responding to Changing Serological and Viral Information around COVID-19 (RESPOND)U54CA260582 · NCI · OHIO STATE UNIVERSITY · PI MCALEARNEY, ANN SCHECK, OLTZ, EUGENE M · 2020 to 2024
$10.4MProject-004U54CA260563 · NCI · EMORY UNIVERSITY · PI DHODAPKAR, MADHAV V, SANZ, IGNACIO E. · 2020 to 2024
$10.2MProject 3: Serological Interactions with the Mucosal Innate Immune System Regulates COVID-19 Associated Tissue Damage.U54CA260543 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WOLFGANG, MATTHEW C · 2020 to 2024
$9.8MDiversity and Determinants of the Immune-Inflammatory Response to SARS-CoV-2U54CA260591 · NCI · CEDARS-SINAI MEDICAL CENTER · PI FIGUEIREDO, JANE C., KARIN, MICHAEL · 2020 to 2024
$9.1MProject-002U01CA260462 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BOPPANA, SURESH B, BRITT, WILLIAM JARVIS · 2020 to 2023
$4.0MSARS-CoV-2 correlates of protection in a Latino-origin populationU01CA260541 · NCI · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI BRIEN, JAMES D, LOPEZ, MARCOS · 2020 to 2024
$3.4MEarly Drivers of Humoral Immunity to SARS-CoV-2 InfectionsU01CA260539 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI KING, CHRISTOPHER L · 2020 to 2024
$3.4MSupplement to U01CA260469U01CA260469 · NCI · MICHIGAN STATE UNIVERSITY · PI LUCAS, TODD WILLIAM · 2020 to 2024
$3.2MHigh-Throughput Dried Blood Spot (HT-DBS) Technologies in SARS COV-2 Serology and VaccinologyU01CA260508 · NCI · WADSWORTH CENTER · PI MANTIS, NICHOLAS J. · 2020 to 2023
$2.6MDISCOVAR:Disparities in Immune Response to SARS-CoV-2 in ARkansasU01CA260526 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI NEMBHARD, WENDY N · 2020 to 2023
$2.2MNCI NIH HHS 75N91019D00024NCI NIH HHS U01 CA260462NCI NIH HHS U01 CA260469NCI NIH HHS U01 CA260508NCI NIH HHS U01 CA260526NCI NIH HHS U01 CA260539NCI NIH HHS U01 CA260541NCI NIH HHS U01 CA261276NCI NIH HHS U54 CA260492NCI NIH HHS U54 CA260543NCI NIH HHS U54 CA260563NCI NIH HHS U54 CA260582NCI NIH HHS U54 CA260591
Abstract
In October 2020, the National Cancer Institute (NCI) Serological Sciences Network (SeroNet) was established to study the immune response to COVID-19, and "to develop, validate, improve, and implement serological testing and associated technologies" (https://www.cancer.gov/research/key-initiatives/covid-19/coronavirus-research-initiatives/serological-sciences-network). SeroNet is comprised of 25 participating research institutions partnering with the Frederick National Laboratory for Cancer Research (FNLCR) and the SeroNet Coordinating Center. Since its inception, SeroNet has supported collaborative development and sharing of COVID-19 serological assay procedures and has set forth plans for assay harmonization. To facilitate collaboration and procedure sharing, a detailed survey was sent to collate comprehensive assay details and performance metrics on COVID-19 serological assays within SeroNet. In addition, FNLCR established a protocol to calibrate SeroNet serological assays to reference standards, such as the U.S. severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serology standard reference material and first WHO international standard (IS) for anti-SARS-CoV-2 immunoglobulin (20/136), to facilitate harmonization of assay reporting units and cross-comparison of study data. SeroNet institutions reported development of a total of 27 enzyme-linked immunosorbent assay (ELISA) methods, 13 multiplex assays, and 9 neutralization assays and use of 12 different commercial serological methods. FNLCR developed a standardized protocol for SeroNet institutions to calibrate these diverse serological assays to reference standards. In conclusion, SeroNet institutions have established a diverse array of COVID-19 serological assays to study the immune response to SARS-CoV-2 and vaccines. Calibration of SeroNet serological assays to harmonize results reporting will facilitate future pooled data analyses and study cross-comparisons.
Indexed as
COVID-19Antibodies, ViralCOVID-19 TestingHumansSARS-CoV-2Serologic TestsAntibodies, Viralassay harmonizationCOVID-19serologySeroNet
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