Evidence map›Paper›PMID 35703534›Full record

ArticleMolecular and cellular biology2022

The RNA-Binding Protein HuR Posttranscriptionally Regulates the Protumorigenic Activator YAP1 in Pancreatic Ductal Adenocarcinoma.

Samantha Z Brown, Grace A McCarthy, James R Carroll, Roberto Di Niro, Carl Pelz, Aditi Jain, Thomas L Sutton, Hannah D Holly, Avinoam Nevler, Christopher W Schultz and 7 more

Open access · greenAbstract read
In one paragraph

Article in Molecular and cellular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Samantha Z BrownDepartment of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-6506-246X
Grace A McCarthyDepartment of Surgery, Oregon Health & Science University, Portland, Oregon, USA.
James R CarrollDepartment of Surgery, Oregon Health & Science University, Portland, Oregon, USA.
Roberto Di NiroDepartment of Surgery, Oregon Health & Science University, Portland, Oregon, USA.
Carl PelzDepartment of Molecular & Medical Genetics, Oregon Health & Science University, Portland, Oregon, USA.
Aditi JainDepartment of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Philadelphia, Pennsylvania, USA.
Thomas L SuttonDepartment of Surgery, Oregon Health & Science University, Portland, Oregon, USA.
Hannah D HollyBrenden-Colson Center for Pancreatic Care, Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.
Avinoam NevlerDepartment of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Philadelphia, Pennsylvania, USA.
Christopher W SchultzDepartment of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Philadelphia, Pennsylvania, USA.
Matthew D McCoyDepartment of Oncology, Innovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington, DC, USA.
Joseph A CozzitortoDepartment of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Philadelphia, Pennsylvania, USA.
Wei JiangDepartment of Pathology, Thomas Jefferson Universitygrid.265008.9, Philadelphia, Pennsylvania, USA.
Charles J YeoDepartment of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Philadelphia, Pennsylvania, USA.
Dan A DixonDepartment of Molecular Biosciences, University of Kansas Cancer Center, University of Kansas, Lawrence, Kansas, USA.ORCID 0000-0001-5631-4365
Rosalie C SearsBrenden-Colson Center for Pancreatic Care, Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.
Jonathan R BrodyDepartment of Surgery, Oregon Health & Science University, Portland, Oregon, USA.ORCID 0000-0003-3680-3270
Oregon Health & Science University · USGeorgetown University · USThe University of Kansas Cancer Center · USThomas Jefferson University · US

Funding

Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
Hydroxylation regulation of c-MycR01CA186241 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Mu-Shui Dai, ROSALIE C SEARS · 2015 to 2026
$4.2M
Comparative analysis between patient-derived models of pancreatic ductal adenocarcinomas and matched tumor specimensU01CA224012 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI BRODY, JONATHAN, COUSSENS, LISA M. · 2019 to 2023
$2.9M
The Role of post-translational activation of Myc in pancreatic cancerR01CA196228 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI SEARS, ROSALIE C · 2015 to 2019
$2.0M
Targeting HuR to improve a synthetic lethal therapy for pancreatic cancerR01CA212600 · NCI · THOMAS JEFFERSON UNIVERSITY · PI BRODY, JONATHAN · 2017 to 2021
$1.9M
NCATS NIH HHS UL1 TR001409NCI NIH HHS R01 CA186241NCI NIH HHS R01 CA196228NCI NIH HHS R01 CA212600NCI NIH HHS U01 CA224012
6 · The paper itself

Abstract

Yes-associated protein 1 (YAP1) is indispensable for the development of mutant

Indexed as

Carcinoma, Pancreatic DuctalPancreatic Neoplasms3' Untranslated RegionsCell Line, TumorELAV-Like Protein 1Gene Expression Regulation, NeoplasticHumansRNA-Binding ProteinsRNA, MessengerRNA, Small InterferingYAP-Signaling Proteins3' Untranslated RegionsELAVL1 protein, humanELAV-Like Protein 1RNA-Binding ProteinsRNA, MessengerRNA, Small InterferingYAP1 protein, humanYAP-Signaling ProteinsHuRpancreatic cancerPDACposttranscriptional regulationYAP1

Identifiers

PMID35703534
PMCPMC9302082
OpenAlexW4282926753

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.