Evidence map›Paper›PMID 35703113›Full record

ArticleFuture oncology (London, England)2022

A phase II clinical trial of neoadjuvant sasanlimab and stereotactic body radiation therapy as an

Raj Satkunasivam, Kelvin Lim, Bin S Teh, Jonathan Guzman, Jun Zhang, Andrew Farach, Shu-Hsia Chen, Christopher Jd Wallis, Eleni Efstathiou, Nestor F Esnaola and 1 more

Open access · greenAbstract readClinical Trial Protocol
In one paragraph

Article in Future oncology (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Raj SatkunasivamCenter for Outcomes Research, Houston Methodist Hospital, Houston, TX 77030, USA.
Kelvin LimDepartment of Urology, Houston Methodist Hospital, Houston, TX 77030, USA.ORCID 0000-0002-8841-8676
Bin S TehDepartment of Radiation Oncology, Houston Methodist Hospital, Houston, TX 77030, USA.
Jonathan GuzmanDepartment of Urology, Houston Methodist Hospital, Houston, TX 77030, USA.
Jun ZhangDepartment of Medical Oncology, Houston Methodist Cancer Center, Houston, TX 77030, USA.
Andrew FarachDepartment of Radiation Oncology, Houston Methodist Hospital, Houston, TX 77030, USA.
Shu-Hsia ChenCenter for Immunotherapy Research, Houston Methodist Research Institute, Houston, TX 77030, USA.
Christopher Jd WallisDivision of Urology, University of Toronto, Toronto, ON M5G 1E2, Canada.
Eleni EfstathiouDepartment of Medical Oncology, Houston Methodist Cancer Center, Houston, TX 77030, USA.
Nestor F EsnaolaDepartment of Surgical Oncology, Houston Methodist Hospital, Houston, TX 77030, USA.
Guru P SonpavdeDepartment of Genitourinary Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Houston Methodist · USMethodist Hospital · USDana-Farber Cancer Institute · USLenox Hill Hospital · USMount Sinai Hospital · CA

Funding

LILRB modulates tumor microenvironment and promotes tumor progressionR01CA204191 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI CHEN, SHU-HSIA · 2017 to 2022
$2.2M
NCI NIH HHS R01 CA204191Pfizer Study Drug (sasanlimab) Funding
6 · The paper itself

Abstract

The utilization of neoadjuvant immune checkpoint inhibitor therapy, specifically anti-PD-1/L1 agents, prior to radical cystectomy is an emerging paradigm in muscle-invasive bladder cancer (MIBC).

Indexed as

Neoadjuvant TherapyRadiosurgeryUrinary Bladder NeoplasmsVaccinesAntibodies, Monoclonal, HumanizedCisplatinClinical Trials, Phase II as TopicCombined Modality TherapyCystectomyHumansImmune Checkpoint InhibitorsAntibodies, Monoclonal, HumanizedCisplatinImmune Checkpoint InhibitorsVaccinesimmune checkpoint inhibitionimmune checkpoint inhibitorimmunoradiationmuscle-invasive bladder cancermuscle-invasive urothelial carcinomaPD-1 inhibitorsasanlimabstereotactic body radiation therapyurothelial bladder carcinomaurothelial carcinoma

Identifiers

PMID35703113
PMCPMC12509955
OpenAlexW4282970409

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.