Evidence map›Paper›PMID 35702728›Full record

ArticleBrain communications2022

Astrocytic function is associated with both amyloid-β and tau pathology in non-demented

Nicola Spotorno, Chloé Najac, Erik Stomrud, Niklas Mattsson-Carlgren, Sebastian Palmqvist, Danielle van Westen, Itamar Ronen, Oskar Hansson

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Journal of Korean medical science · 2026
    Article
  3. Neurobiology of aging · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Multifaceted roles of APOE in Alzheimer disease.Nature reviews. Neurology · 2024
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Nicola SpotornoClinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.ORCID https://orcid.org/0000-0001-5404-8788
Chloé NajacDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Erik StomrudClinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.
Niklas Mattsson-CarlgrenClinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.ORCID https://orcid.org/0000-0002-8885-7724
Sebastian PalmqvistClinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.
Danielle van WestenImage and Function, Skane University Hospital, Lund, Sweden.ORCID https://orcid.org/0000-0001-8649-9874
Itamar RonenDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Oskar HanssonClinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.ORCID https://orcid.org/0000-0001-8467-7286
Lund University · SELeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A growing body of evidence suggests that astrocytes play a major role in the pathophysiology of Alzheimer's disease. Given that

Indexed as

Alzheimer’s diseaseamyloid-βAPOEastrocytesmyo-inositol

Identifiers

PMID35702728
PMCPMC9185373
OpenAlexW4281257092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.