Evidence map›Paper›PMID 35702561›Full record

ArticleCase reports in oncology

Human Immature Dental Pulp Stem Cells Did Not Graft into a Preexisting Human Lung Adenocarcinoma.

Joyce Macedo da Silva, Rodrigo Pinheiro Araldi, Gabriel Avelar Colozza-Gama, Eduardo Pagani, Ariye Sid, Cristiane Wenceslau Valverde, Irina Kerkis

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Joyce Macedo da SilvaAzidus Brazil, São Paulo, Brazil.
Rodrigo Pinheiro AraldiGenetics Laboratory, Butantan Institute, São Paulo, Brazil.
Gabriel Avelar Colozza-GamaStructural and Functional Biology Post-graduation Program, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Eduardo PaganiAzidus Brazil, São Paulo, Brazil.
Ariye SidAzidus Brazil, São Paulo, Brazil.
Cristiane Wenceslau ValverdeCellavita Scientific Researches, São Paulo, Brazil.
Irina KerkisGenetics Laboratory, Butantan Institute, São Paulo, Brazil.
Instituto Butantan · BRUniversidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cell (MSC)-based therapies have been considered an attractive approach for treating Huntington's disease (HD). However, due to the pulmonary first-passage effect associated with intravenous infusion (the most commonly used route of MSC administration), there is a rising concern that the cells could be entrapped in the lungs and grafted (homing) into preexisting lung cancer. Herein, we report the case of a patient with HD enrolled in a cell therapy phase I clinical trial for HD treatment having a preexisting pulmonary nodule. The nodule was found at the trial screening. The patient was referred to a pulmonologist who considered the nodule non-cancer and authorized enrollment. The patient received four intravenous administrations of human immature dental pulp stem cells (hIDPSCs) at the dose of 1 × 10

Indexed as

Human immature dental pulp stem cellHuntington's diseaseLung adenocarcinomaRNA-sequencingSafety

Identifiers

PMID35702561
PMCPMC9149538
OpenAlexW4224247311

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.