Evidence map›Paper›PMID 35702522›Full record

ArticleCase reports in ophthalmology

Third Cranial Nerve Palsy after Monoclonal Antibody Therapy for Lung Cancer: A Case Report.

Paolo Missori, Angela Ambrosone, Leonardo Cristofani, Francesco Fattapposta, Antonio Currà

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Paolo MissoriDepartment of Human Neuroscience, Neurosurgery, "Sapienza" University of Rome, Policlinico Umberto I, Rome, Italy.
Angela AmbrosoneDepartment of Human Neuroscience, Neurosurgery, "Sapienza" University of Rome, Policlinico Umberto I, Rome, Italy.
Leonardo CristofaniDepartment of Radiological, Oncological and Anatomo-Pathological Sciences, "Sapienza" University of Rome, Policlinico Umberto I, Rome, Italy.
Francesco FattappostaDepartment of Human Neuroscience, Neurology Unit A, "Sapienza" University of Rome, Policlinico Umberto I, Rome, Italy.
Antonio CurràDepartment of Medical-Surgical Sciences and Biotechnologies, Academic Neurology Unit, "Sapienza" University of Rome, Ospedale A. Fiorini, Rome, Italy.
Policlinico Umberto I · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune checkpoint inhibitors (ICIs) have shown promise in treating cancer patients, and pembrolizumab is a monoclonal IgG4 antibody that targets a human cell surface protein (receptor) called PD-1. Among the side effects, a rare cranial nerve palsy unrelated to the surgical treatment may occur. We report a case of a woman, which after neurosurgical treatment for cerebellar metastasis presented painless third cranial nerve palsy. The benefits of ICIs have been ascertained, but side effects also take place. Neurological symptoms should be recognized early to avoid substantial morbidity, and if necessary, the oncologic treatment should be changed.

Indexed as

CancerCranial nerveLungMetastasisPembrolizumabSide effects

Identifiers

PMID35702522
PMCPMC9149351
OpenAlexW4224250300

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.