Evidence map›Paper›PMID 35702333›Full record

ArticleInternational journal of bioprinting2022

Deep Learning-Assisted Nephrotoxicity Testing with Bioprinted Renal Spheroids.

Kevin Tröndle, Guilherme Miotto, Ludovica Rizzo, Roman Pichler, Fritz Koch, Peter Koltay, Roland Zengerle, Soeren S Lienkamp, Sabrina Kartmann, Stefan Zimmermann

Open access · diamondAbstract read
In one paragraph

Article in International journal of bioprinting, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Machine learning and 3D bioprinting.International journal of bioprinting · 2023
    Article
  7. Machine learning boosts three-dimensional bioprinting.International journal of bioprinting · 2023
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Kevin TröndleUniversity of Freiburg, IMTEK - Department of Microsystems Engineering, Freiburg, 79110, Germany.
Guilherme MiottoHahn-Schickard, Freiburg, 79110, Germany.
Ludovica RizzoInstitute of Anatomy, University of Zurich, Zurich, Switzerland.
Roman PichlerRenal Division, Department of Medicine, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.
Fritz KochUniversity of Freiburg, IMTEK - Department of Microsystems Engineering, Freiburg, 79110, Germany.
Peter KoltayUniversity of Freiburg, IMTEK - Department of Microsystems Engineering, Freiburg, 79110, Germany.
Roland ZengerleUniversity of Freiburg, IMTEK - Department of Microsystems Engineering, Freiburg, 79110, Germany.
Soeren S LienkampInstitute of Anatomy, University of Zurich, Zurich, Switzerland.
Sabrina KartmannUniversity of Freiburg, IMTEK - Department of Microsystems Engineering, Freiburg, 79110, Germany.
Stefan ZimmermannUniversity of Freiburg, IMTEK - Department of Microsystems Engineering, Freiburg, 79110, Germany.
University of Freiburg · DEUniversity of Zurich · CHHahn-Schickard-Gesellschaft für angewandte Forschung · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We used arrays of bioprinted renal epithelial cell spheroids for toxicity testing with cisplatin. The concentration-dependent cell death rate was determined using a lactate dehydrogenase assay. Bioprinted spheroids showed enhanced sensitivity to the treatment in comparison to monolayers of the same cell type. The measured dose-response curves revealed an inhibitory concentration of the spheroids of

Indexed as

BioprintingDeep learningKidneyNephrotoxicitySpheroids

Identifiers

PMID35702333
PMCPMC9186384
OpenAlexW4281743649

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.