Evidence map›Paper›PMID 35702292›Full record

ArticleFood science & nutrition2022

Effects of 4-Oxo-2-nonenal on biochemical properties of bovine heart mitochondria.

Anand Mohan, Deepak Kafle, Rakesh K Singh, Yen-Con Hung

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food science & nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Anand MohanDepartment of Food Science and Technology College of Agricultural and Environmental Science University of Georgia Athens Georgia USA.ORCID https://orcid.org/0000-0003-2174-9005
Deepak KafleDepartment of Food Science and Technology College of Agricultural and Environmental Science University of Georgia Athens Georgia USA.
Rakesh K SinghDepartment of Food Science and Technology College of Agricultural and Environmental Science University of Georgia Athens Georgia USA.
Yen-Con HungDepartment of Food Science and Technology College of Agricultural and Environmental Science University of Georgia Athens Georgia USA.
University of Georgia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effects of lipid peroxidation products 4-Hydroxy-2-nonenal (4-HNE) and 4-oxo-2-nonenal (4-ONE) were evaluated using bovine heart mitochondria. Oxygen consumption rate (OCR), ultrastructure, antioxidant activity, and membrane permeability were examined to compare their effects on isolated mitochondria from beef cardiac muscle. For the mitochondrial morphology, the final concentration of mitochondria and 4-ONE or 4-HNE in the reaction tube were 10 mg/ml and 1 mM, respectively. For the OCR experiment, mitochondria (2.5 mg/ml) were incubated with 0.20 mM ONE or in a Clark electrode chamber at 25°C. Mitochondrial membrane permeability was determined by incubating 0.5 mg/ml of mitochondrial protein with either 0.05 mM ONE or HNE or ethanol control at pH 5.6 and 7.4 at 25°C. Transmission electron microscopy (TEM) revealed that the size of 4-ONE treated mitochondria at pH 7.4 increased (

Indexed as

4‐Hydroxy‐2‐nonenal4‐oxo‐2‐nonenalantioxidant propertieslipid oxidationmitochondriaoxygen consumption

Identifiers

PMID35702292
PMCPMC9179123
OpenAlexW4221095163

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.