Evidence map›Paper›PMID 35702248›Full record

ArticleRSC advances2022

Amino acids with fluorescent tetrazine ethers as bioorthogonal handles for peptide modification.

Enric Ros, Marina Bellido, Joan A Matarin, Albert Gallen, Manuel Martínez, Laura Rodríguez, Xavier Verdaguer, Lluís Ribas de Pouplana, Antoni Riera

Abstract read
In one paragraph

Article in RSC advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Enric RosInstitute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology Baldiri Reixac 10 08028 Barcelona Spain antoni.riera@irbbarcelona.org.ORCID https://orcid.org/0000-0001-6269-3058
Marina BellidoInstitute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology Baldiri Reixac 10 08028 Barcelona Spain antoni.riera@irbbarcelona.org.
Joan A MatarinInstitute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology Baldiri Reixac 10 08028 Barcelona Spain antoni.riera@irbbarcelona.org.
Albert GallenDepartament de Química Inorgànica i Orgànica, Secció Química Inorgànica. Universitat de Barcelona Martí i Franquès 1 08028 Barcelona Spain.ORCID https://orcid.org/0000-0002-9563-8802
Manuel MartínezDepartament de Química Inorgànica i Orgànica, Secció Química Inorgànica. Universitat de Barcelona Martí i Franquès 1 08028 Barcelona Spain.ORCID https://orcid.org/0000-0002-6289-4586
Laura RodríguezDepartament de Química Inorgànica i Orgànica, Secció Química Inorgànica. Universitat de Barcelona Martí i Franquès 1 08028 Barcelona Spain.
Xavier VerdaguerInstitute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology Baldiri Reixac 10 08028 Barcelona Spain antoni.riera@irbbarcelona.org.ORCID https://orcid.org/0000-0002-9229-969X
Lluís Ribas de PouplanaInstitute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology Baldiri Reixac 10 08028 Barcelona Spain antoni.riera@irbbarcelona.org.
Antoni RieraInstitute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology Baldiri Reixac 10 08028 Barcelona Spain antoni.riera@irbbarcelona.org.ORCID https://orcid.org/0000-0001-7142-7675

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A set of 3-bromo-1,2,4,5-tetrazines with three distinct substitutions have been used as reagents for late-stage functionalization of small molecules through nucleophilic aromatic substitution. Spectroscopic studies of the products obtained proved that tetrazine ethers are intrinsically fluorescent. This fluorescence is lost upon inverse Electron-Demand Diels-Alder (iEDDA) cycloaddition with strained alkenes. Tetrazine-phenol ethers are rather interesting because they can undergo rapid iEDDA reactions with a second order rate constant (

Identifiers

PMID35702248
PMCPMC9096626

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.