Evidence map›Paper›PMID 35702158›Full record

ArticlebioRxiv : the preprint server for biology2022

Gene amplification acts as a molecular foothold to facilitate cross-species adaptation and evasion of multiple antiviral pathways.

Shefali Banerjee, Cathy Smith, Adam Geballe, Stefan Rothenburg, Jacob O Kitzman, Greg Brennan

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Shefali BanerjeeDepartment of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, Davis, CA 95616, USA.
Cathy SmithDepartments of Human Genetics and Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Adam GeballeDivisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Center, Seattle, WA, 98109 USA.
Stefan RothenburgDepartment of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, Davis, CA 95616, USA.
Jacob O KitzmanDepartments of Human Genetics and Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Greg BrennanDepartment of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, Davis, CA 95616, USA.
The University of Texas Medical Branch at Galveston · USUniversity of Michigan · USUniversity of Washington · US

Funding

Roles of Experimentally Evolved Vaccinia Mutations in Antagonizing Cell DefensesR21AI109340 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GEBALLE, ADAM P. · 2014 to 2015
$484k
Molecular and evolutionary mechanisms of poxviral adaptation to new speciesR21AI135257 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BRENNAN, GREGORY JASON, KITZMAN, JACOB OTTO · 2019 to 2020
$446k
NIAID NIH HHS R21 AI109340NIAID NIH HHS R21 AI135257
6 · The paper itself

Abstract

Cross-species spillover events are responsible for many of the pandemics in human history including COVID-19; however, the evolutionary mechanisms that enable these events are poorly understood. We have previously modeled this process using a chimeric vaccinia virus expressing the rhesus cytomegalovirus-derived PKR antagonist RhTRS1 in place of its native PKR antagonists; E3L and K3L (VACVΔEΔK+RhTRS1). Using this virus, we demonstrated that gene amplification of

Identifiers

PMID35702158
PMCPMC9196108
OpenAlexW4281643868

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.