Evidence map›Paper›PMID 35702123›Full record

ArticleAmerican journal of translational research2022

BMI1 governs the maintenance of mouse GC-2 cells through epigenetic repression of

Bo Zheng, Juanjuan Liu, Xiaodan Shi, Jinfu Xu, Ke Zhang, Hui Zhou, Tiantian Wu, Xiaoyan Huang, Cong Shen, Yuting Liang and 2 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Bo ZhengState Key Laboratory of Reproductive Medicine, Center for Reproduction and Genetics, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University Suzhou 215002, Jiangsu, China.
Juanjuan LiuReproductive Medicine Center, The Second Affiliated Hospital of Soochow University Suzhou 215004, Jiangsu, China.
Xiaodan ShiDepartment of Reproduction, The Affiliated Obstetrics and Gynecology Hospital with Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital Nanjing 210004, Jiangsu, China.
Jinfu XuState Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University Nanjing 211166, Jiangsu, China.
Ke ZhangDepartment of Urology, The Second Affiliated Hospital of Soochow University Suzhou 215004, Jiangsu, China.
Hui ZhouHuman Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University Wuxi 214122, Jiangsu, China.
Tiantian WuState Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University Nanjing 211166, Jiangsu, China.
Xiaoyan HuangState Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University Nanjing 211166, Jiangsu, China.
Cong ShenState Key Laboratory of Reproductive Medicine, Center for Reproduction and Genetics, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University Suzhou 215002, Jiangsu, China.
Yuting LiangCenter for Clinical Laboratory, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu, China.
Dan ZhaoFourth Affiliated Hospital of Jiangsu University Zhenjiang 212008, Jiangsu, China.
Yueshuai GuoState Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University Nanjing 211166, Jiangsu, China.
Nanjing Medical University · CNSoochow University · CNSuzhou Municipal Hospital · CNJiangnan University · CNJiangsu University · CNNanjing Maternity and Child Health Care Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesStudies have demonstrated that B lymphoma Mo-MLV insertion region 1 (BMI1) plays an important role in male reproductive function and the regulation of spermatogonia proliferation. However, whether BMI1 exerts a similarly important function in spermatocyte development remains unclear.

methodsIn this study, we investigated the role of BMI1 in spermatocyte development using a mouse spermatocyte-derived cell line (GC-2) and a

resultsWe demonstrated that BMI1 promoted the proliferation and inhibited the apoptosis of GC-2 cells. Mechanistically, we presented

conclusionsCollectively, our study revealed for the first time the existence of an epigenetic mechanism involving BMI1-mediated gene silencing in GC-2 cells development and provided potential targets for the treatment of male infertility.

Indexed as

BMI1Foxl1GC-2spermatocyteβ-catenin

Identifiers

PMID35702123
PMCPMC9185053
OpenAlexW4285742766

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.