ArticleMovement disorders : official journal of the Movement Disorder Society2022
Cortical and Subthalamic Nucleus Spectral Changes During Limb Movements in Parkinson's Disease Patients with and Without Dystonia.
Article in Movement disorders : official journal of the Movement Disorder Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03409120 (Unlocking Dystonia From Parkinson's Disease With Directional DBS Technology), which is not on this map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Unlocking Dystonia From Parkinson's Disease With Directional DBS Technology
Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Differential Cognitive Effects of Unilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease.Annals of neurology · 2024Trial
- Use of the PROMIS and Neuro-QoL to Evaluate Health-Related Quality of Life following Unilateral Subthalamic Deep Brain Stimulation for Parkinson's Disease.Movement disorders clinical practice · 2026Article
- Article
- Differential contribution of sensorimotor cortex and subthalamic nucleus to unimanual and bimanual hand movements.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Subthalamic Nucleus Stimulation-Induced Local Field Potential Changes in Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- Differential cognitive effects of unilateral left and right subthalamic nucleus deep brain stimulation for Parkinson disease.medRxiv : the preprint server for health sciences · 2023Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDystonia is an understudied motor feature of Parkinson's disease (PD). Although considerable efforts have focused on brain oscillations related to the cardinal symptoms of PD, whether dystonia is associated with specific electrophysiological features is unclear.
objectiveThe objective of this study was to investigate subcortical and cortical field potentials at rest and during contralateral hand and foot movements in patients with PD with and without dystonia.
methodsWe examined the prevalence and distribution of dystonia in patients with PD undergoing deep brain stimulation surgery. During surgery, we recorded intracranial electrophysiology from the motor cortex and directional electrodes in the subthalamic nucleus (STN) both at rest and during self-paced repetitive contralateral hand and foot movements. Wavelet transforms and mixed models characterized changes in spectral content in patients with and without dystonia.
resultsDystonia was highly prevalent at enrollment (61%) and occurred most commonly in the foot. Regardless of dystonia status, cortical recordings display beta (13-30 Hz) desynchronization during movements versus rest, while STN signals show increased power in low frequencies (6.0 ± 3.3 and 4.2 ± 2.9 Hz peak frequencies for hand and foot movements, respectively). Patients with PD with dystonia during deep brain stimulation surgery displayed greater M1 beta power at rest and STN low-frequency power during movements versus those without dystonia.
conclusionsSpectral power in motor cortex and STN field potentials differs markedly during repetitive limb movements, with cortical beta desynchronization and subcortical low-frequency synchronization, especially in patients with PD with dystonia. Greater knowledge on field potential dynamics in human motor circuits can inform dystonia pathophysiology in PD and guide novel approaches to therapy. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.