Evidence map›Paper›PMID 35701843›Full record

ArticleArthritis research & therapy2022

Systemic lupus erythematosus dysregulates the expression of long noncoding RNAs in placentas.

Hui-Hui Li, Lin-Tao Sai, Yuan Liu, Colman I Freel, Kai Wang, Chi Zhou, Jing Zheng, Qiang Shu, Ying-Jie Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Hui-Hui Li *Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Lin-Tao Sai *Department of Infectious Diseases, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Yuan LiuDepartment of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Colman I FreelDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, 53715, USA.
Kai WangClinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.
Chi ZhouSchool of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ, 85719, USA.
Jing ZhengDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, 53715, USA.
Qiang ShuDepartment of Rheumatology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China. shuqiang@sdu.edu.cn.
Ying-Jie ZhaoDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, 53715, USA. yzhaoqilu@sdu.edu.cn.ORCID 0000-0002-0367-2908
Shandong University · CNUniversity of Wisconsin–Madison · USNebraska Medical Center · USQilu Hospital of Shandong University · CNShanghai First Maternity and Infant Hospital · CNUniversity of Arizona · USUniversity of Wisconsin System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSystemic lupus erythematosus (SLE) can cause placental dysfunctions, which may result in pregnancy complications. Long noncoding RNAs (lncRNAs) are actively involved in the regulation of immune responses during pregnancy. The present study aimed to determine the lncRNA expression profiles in placentas from women with SLE to gain new insights into the underlying molecular mechanisms in SLE pregnancies.

methodsRNA sequencing (RNA-seq) analysis was performed to identify SLE-dysregulated lncRNAs and mRNAs in placentas from women with SLE and normal full-term (NT) pregnancies. Bioinformatics analysis was conducted to predict the biological functions of these SLE-dysregulated lncRNAs and mRNAs.

resultsRNA-seq analysis identified 52 dysregulated lncRNAs in SLE placentas, including 37 that were upregulated and 15 downregulated. Additional 130 SLE-dysregulated mRNAs were discovered, including 122 upregulated and 8 downregulated. Bioinformatics analysis revealed that SLE-dysregulated genes were associated with biological functions and gene networks, such as regulation of type I interferon-mediated signaling pathway, response to hypoxia, regulation of MAPK (mitogen-activated protein kinase) cascade, response to steroid hormone, complement and coagulation cascades, and Th1 and Th2 cell differentiation.

conclusionsThis is the first report of the lncRNA profiles in placentas from SLE pregnancies. These results suggest that the aberrant expression and the potential regulatory function of lncRNAs in placentas may play comprehensive roles in the pathogenesis of SLE pregnancies. SLE-dysregulated lncRNAs may potentially serve as biomarkers for SLE.

Indexed as

Lupus Erythematosus, SystemicRNA, Long NoncodingFemaleGene Expression ProfilingGene Regulatory NetworksHumansPlacentaPregnancyRNA, MessengerRNA, Long NoncodingRNA, MessengerlncRNAPlacentaRNA sequencingSystemic lupus erythematosus

Identifiers

PMID35701843
PMCPMC9195362
OpenAlexW4282838207

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.