Evidence map›Paper›PMID 35701824›Full record

ArticleCanine medicine and genetics2022

English Bulldogs in the UK: a VetCompass study of their disorder predispositions and protections.

Dan G O'Neill, Alison Skipper, Rowena M A Packer, Caitriona Lacey, Dave C Brodbelt, David B Church, Camilla Pegram

Open access · goldAbstract read
In one paragraph

Article in Canine medicine and genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 27 citations in OpenAlex.

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  16. Dermatological Problems of Brachycephalic Dogs.Animals : an open access journal from MDPI · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Dan G O'NeillPathobiology and Population Sciences, The Royal Veterinary College, North Mymms, Hawkshead Lane, Hatfield, AL9 7TA, Herts, UK. doneill@rvc.ac.uk.
Alison SkipperDepartment of History, King's College London, Strand, London, WC2R 2LS, UK.
Rowena M A PackerClinical Science and Services, The Royal Veterinary College, North Mymms, Hawkshead Lane, Hatfield, AL9 7TA, Herts, UK.
Caitriona LaceyPathobiology and Population Sciences, The Royal Veterinary College, North Mymms, Hawkshead Lane, Hatfield, AL9 7TA, Herts, UK.
Dave C BrodbeltPathobiology and Population Sciences, The Royal Veterinary College, North Mymms, Hawkshead Lane, Hatfield, AL9 7TA, Herts, UK.
David B ChurchClinical Science and Services, The Royal Veterinary College, North Mymms, Hawkshead Lane, Hatfield, AL9 7TA, Herts, UK.
Camilla PegramPathobiology and Population Sciences, The Royal Veterinary College, North Mymms, Hawkshead Lane, Hatfield, AL9 7TA, Herts, UK.
Royal Veterinary College · GBKing's College London · GB

Funding

Kennel Club Charitable Trust Kennel Club Charitable TrustWellcome Trust 203385/Z/16/Z
6 · The paper itself

Abstract

backgroundThe English Bulldog has risen sharply in popularity over the past decade but its distinctive and extreme conformation is linked to several serious health conditions. Using multivariable analysis of anonymised veterinary clinical data from the VetCompass Programme, this study compared the odds of common disorders between English Bulldogs and all remaining dogs in the UK during 2016.

resultsFrom 905,544 dogs under veterinary care during 2016, the analysis included a random sample of 2,662 English Bulldogs and 22,039 dogs that are not English Bulldogs. English Bulldogs had 2.04 times the odds of diagnosis with ≥ 1 disorder than dogs that are not English Bulldogs (95% confidence interval [CI] 1.85 to 2.25). At a specific-level of diagnostic precision, English Bulldogs had increased odds of 24/43 (55.8%) disorders. These included: skin fold dermatitis (odds ratio [OR] 38.12; 95% CI 26.86 to 54.10), prolapsed nictitating membrane gland (OR 26.79; 95% CI 18.61 to 38.58) and mandibular prognathism (OR 24.32; 95% CI 13.59 to 43.53). Conversely, English Bulldogs had significantly reduced odds of 6/43 (14.0%) disorders. These included: retained deciduous tooth (OR 0.02; 95% CI 0.01 to 0.17), lipoma (OR 0.06; 95% CI 0.01 to 0.40) and periodontal disease (OR 0.23; 95% CI 0.18 to 0.30). At a grouped-level of diagnostic precision, English Bulldogs had significantly increased odds of 17/34 (50.0%) disorders. These included: congenital disorder (OR 7.55; 95% CI 5.29 to 10.76), tail disorder (OR 6.01; 95% CI 3.91 to 9.24) and lower respiratory tract disorder (OR 5.50; 95% CI 4.11 to 7.35). Conversely, English Bulldogs had significantly reduced odds of 3/34 (8.8%) disorders. These were: dental disorder (OR 0.25; 95% CI 0.20 to 0.31), spinal cord disorder (OR 0.31; 95% CI 0.14 to 0.71) and appetite disorder (OR 0.43; 95% CI 0.20 to 0.91).

conclusionsThese results suggest that the health of English Bulldogs is substantially lower than dogs that are not English Bulldogs and that many predispositions in the breed are driven by the extreme conformation of these dogs. Consequently, immediate redefinition of the breed towards a moderate conformation is strongly advocated to avoid the UK joining the growing list of countries where breeding of English Bulldogs is banned.

Indexed as

BreedDogElectronic patient recordEnglish BulldogEpidemiologyEPRHealthPedigreePrimary-carePurebredVetCompassVeterinary

Identifiers

PMID35701824
PMCPMC9199211
OpenAlexW4282929110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.