Evidence map›Paper›PMID 35701745›Full record

ArticleThe neuroradiology journal2023

Direct cost analysis of rapid MRI in the emergency department evaluation of patients suspected of having acute ischemic stroke*.

Adam de Havenon, Chris Orlando, Alen Delic, Joseph Scott McNally, Jennifer J Majersik, Tyler Harman, Matthew Alexander, Vivek Reddy, Stephanie Lyden, Yoshimi Anzai

Abstract read
In one paragraph

Article in The neuroradiology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  4. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Adam de HavenonDepartment of Neurology, 12228Yale University, New Haven, CT, USA.ORCID 0000-0001-8178-8597
Chris OrlandoDepartment of Neurology, 14434University of Utah, Salt Lake City, UT, USA.
Alen DelicDepartment of Neurology, 14434University of Utah, Salt Lake City, UT, USA.
Joseph Scott McNallyDepartment of Radiology, 12339University of Utah, Salt Lake City, UT, USA.
Jennifer J MajersikDepartment of Neurology, 14434University of Utah, Salt Lake City, UT, USA.
Tyler HarmanDepartment of Neurology, 14434University of Utah, Salt Lake City, UT, USA.
Matthew AlexanderDepartment of Radiology, 12339University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-7534-5842
Vivek ReddyDepartment of Neurology, 14434University of Utah, Salt Lake City, UT, USA.
Stephanie LydenDepartment of Neurology, 14434University of Utah, Salt Lake City, UT, USA.
Yoshimi AnzaiDepartment of Radiology, 12339University of Utah, Salt Lake City, UT, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Treatment Targets for Inflamed Intracranial Atherosclerosis on Vessel Wall MRIK23NS105924 · NINDS · YALE UNIVERSITY · PI DE HAVENON, ADAM H. · 2019 to 2023
$988k
NCATS NIH HHS UL1 TR001863NINDS NIH HHS K23 NS105924
6 · The paper itself

Abstract

backgroundAbbreviated "rapid MRI" protocols have become more common for the evaluation of acute ischemic stroke (AIS). Prior research has not evaluated the effect of rapid MRIs on cost or hospital length of stay in AIS patients.

methodsWe retrospectively identified AIS patients who presented within 6 h of acute neurologic symptom onset to an emergency department (ED) and activated a "brain attack" code. We included sequential patients from January 2012 to September 2015, before rapid MRI was available, who had CT perfusion (CTP) and compared them to patients from October 2015 to May 2018 who had a rapid MRI. We used inverse-probability-weighting (IPW) to balance the cohorts. The primary outcomes were direct cost to our healthcare system and total hospital length of stay (LOS).

resultsWe included 408 brain attack activations (mean ± SD age 62.1 ± 17.6 years, 47.8% male): 257 in the CTP cohort and 151 in the MRI cohort. Discharge diagnosis was ischemic stroke in 193/408 (47.3%). After patient matching, we found significant reductions for the MRI cohort in total cost (-18.7%, 95% CI -35.0, -2.4,

conclusionAlthough these results are preliminary and hypothesis-generating, we found that the use of a rapid MRI protocol in emergency department brain attacks was associated with a 18.7% reduction in total direct cost and 17% reduction in hospital length of stay.

Indexed as

Ischemic StrokeStrokeAdultAgedCosts and Cost AnalysisEmergency Service, HospitalFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRetrospective Studiesacute evaluationcost-effectivenessischemic strokeMRI

Identifiers

PMID35701745
PMCPMC10034695

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.