Evidence map›Paper›PMID 35701730›Full record

ArticleBMC infectious diseases2022

Post-COVID-19 related osteonecrosis of the jaw (PC-RONJ): an alarming morbidity in COVID-19 surviving patients.

Haytham Al-Mahalawy, Yehia El-Mahallawy, Noha Y Dessoky, Sally Ibrahim, Hatem Amer, Haytham Mohamed Ayad, Hagar Mahmoud El Sherif, Alshaimaa Ahmed Shabaan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Post-COVID-19 Jaw Osteonecrosis: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026
    Review
  3. Review
  4. Review
  5. COVID-19 Influence on Mandibular Dry Socket Occurrence.World journal of plastic surgery · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Self-Reported Periodontal Disease and Its Association with SARS-CoV-2 Infection.International journal of environmental research and public health · 2022
    Article
  11. Article
  12. Article
  13. [Craniofacial osteomyelitis in a patient with systemic involvement: a case report].Revista cientifica odontologica (Universidad Cientifica del Sur)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Haytham Al-MahalawyOral and Maxillofacial Surgery Department, Faculty of Dentistry, Fayoum University, Fayoum, Egypt.
Yehia El-MahallawyOral and Maxillofacial Surgery Department, Faculty of Dentistry, Alexandria University, Champlion st, Azrite, Alexandria, Egypt. yehia.el-mahallawy@alexu.edu.eg.
Noha Y DessokyOral and Maxillofacial Surgery Department, Faculty of Dentistry, Alexandria University, Champlion st, Azrite, Alexandria, Egypt.
Sally IbrahimOral & Maxillofacial Pathology Department, Faculty of Dentistry, Fayoum University, Fayoum, Egypt.
Hatem AmerOral & Maxillofacial Pathology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.
Haytham Mohamed AyadOral and Maxillofacial Surgery Department, Faculty of Dentistry, Fayoum University, Fayoum, Egypt.
Hagar Mahmoud El SherifOral & Maxillofacial Surgery at Nasser Institute Hospital for Research & Treatment, Cairo, Egypt.
Alshaimaa Ahmed ShabaanOral and Maxillofacial Surgery Department, Faculty of Dentistry, Fayoum University, Fayoum, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe recent coronavirus disease (COVID-19) pandemic mainly affects the respiratory system; however, several oral and maxillofacial post-COVID-19 complications have also been observed. This series reports the growing number of osteonecrosis cases associated with post-COVID-19 patients. MATERIALS AND

methodsThis is a retrospective, multi-center case series that reports cases with maxillary osteonecrosis after various periods of SARS-CoV-2 infection in the period between January and August 2021 based on the PROCESS guidelines.

resultsTwelve cases were reported with post-COVID-19 manifestation of spontaneous osteonecrosis of the maxillary jaw. Five patients were hospitalized during COVID-19 management and all of the twelve cases had at least one systematic Co-morbidity, and undertake corticosteroids prescription based on the COVID-19 disease treatment protocol. The mean onset of osteonecrosis symptoms appearance was 5.5 ± 2.43 weeks calculated from the day of the negative PCR test. The management was successfully done through surgical debridement and pre and post-operative antibiotics. No anti-fungal medications were prescribed as the fungal culture and the histopathological report were negative.

conclusionPost-COVID-related osteonecrosis of the jaw (PC-RONJ) could be now considered as one of the potential post-COVID-19 oral and maxillofacial complications that occurs unprovokedly and mainly in the maxilla.

Indexed as

COVID-19OsteonecrosisDiphosphonatesHumansMorbidityRetrospective StudiesSARS-CoV-2DiphosphonatesAvascular necrosisMaxillaOsteonecrosisPost-COVID

Identifiers

PMID35701730
PMCPMC9192922

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.