Evidence map›Paper›PMID 35701686›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2022

Evaluation of Different Doses of the Aromatase Inhibitor Letrozole for the Treatment of Ectopic Pregnancy and Its Effect on Villous Trophoblastic Tissue.

Mohamed Ali Alabiad, Warda M M Said, Abdalla Hassan Gad, Mustafa Taha Abdelfattah Sharaf ElDin, Dina Ahmed Khairy, Mai Ahmed Gobran, Amany Mohamed Shalaby, Walaa Samy, Ahmed Ahmed Abdelsameea, Ahmed Ismail Heraiz

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06354439 (Use of Letrozole in the Treatment of Early Ectopic Pregnancy), which is not on this map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06354439 phase4recruitingnot on this mapstarted 2024, after this paper: background citation

Use of Letrozole in the Treatment of Early Ectopic Pregnancy

TypeinterventionalSponsorHospital de Clinicas de Porto AlegreRan2024 to 2026Enrolled130ConditionsEctopic PregnancyArmsLetrozole tablets, Methotrexate Sodium
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Mohamed Ali AlabiadDepartment of Pathology, Faculty of Medicine, Zagazig University, Zagazig, 44519, Egypt. maabyad@medicine.zu.edu.eg.ORCID 0000-0002-6006-3711
Warda M M SaidDepartment of Pathology, Faculty of Medicine, Benghazi University, Benghazi, Libya.
Abdalla Hassan GadDepartment of Gynecology and Obstetrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Mustafa Taha Abdelfattah Sharaf ElDinDepartment of Gynecology and Obstetrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Dina Ahmed KhairyDepartment of Biomedical Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Mai Ahmed GobranDepartment of Pathology, Faculty of Medicine, Zagazig University, Zagazig, 44519, Egypt.
Amany Mohamed ShalabyDepartment of Histology and Cell Biology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Walaa SamyDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Ahmed Ahmed AbdelsameeaDepartment of Pharmacology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Ahmed Ismail HeraizDepartment of Gynecology and Obstetrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Zagazig University · EGImam Abdulrahman Bin Faisal University · SATanta University · EGUniversity of Benghazi · LY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Letrozole, an aromatase inhibitor, has recently been introduced as a favorable medical treatment for ectopic pregnancy. We aimed at evaluating the effects of different doses of letrozole for termination of ectopic pregnancy and study their effects on villous trophoblastic tissue. Sixty patients with undisturbed ectopic pregnancy were classified into three equal groups. Group I: the control group that contained women who underwent laparoscopic salpingectomy, Group II: patients who received letrozole (5 mg day

Indexed as

Aromatase InhibitorsPregnancy, EctopicCaspase 3EstrogensFemaleHumansLetrozoleNitrilesPlacentaPregnancyProgesteroneReceptors, ProgesteroneReceptors, Vascular Endothelial Growth FactorTriazolesVascular Endothelial Growth Factor AAromatase InhibitorsCaspase 3EstrogensLetrozoleNitrilesProgesteroneReceptors, ProgesteroneReceptors, Vascular Endothelial Growth FactorTriazolesVascular Endothelial Growth Factor ACleaved caspase-3Ectopic pregnancyInduced abortionLetrozolePRTrophoblastic tissue ERVEGF

Identifiers

PMID35701686
PMCPMC9537218
OpenAlexW4282935518

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.