Evidence map›Paper›PMID 35701670›Full record

ArticleEuropean journal of nutrition2022

The FADS1 genotypes modify the effect of linoleic acid-enriched diet on adipose tissue inflammation via pro-inflammatory eicosanoid metabolism.

Maija Vaittinen, Maria A Lankinen, Pirjo Käkelä, Jyrki Ågren, Craig E Wheelock, Markku Laakso, Ursula Schwab, Jussi Pihlajamäki

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Article in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Fatty acid desaturase genetic variations in heart failure and cardiovascular disease.American heart journal plus : cardiology research and practice · 2025
    Review
  4. Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maija VaittinenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, 70210, Kuopio, Finland. maija.vaittinen@uef.fi.ORCID http://orcid.org/0000-0002-7423-557X
Maria A LankinenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, 70210, Kuopio, Finland.
Pirjo KäkeläDepartment of Surgery, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Jyrki ÅgrenInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.
Craig E WheelockDivision of Physiological Chemistry 2, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Markku LaaksoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
Ursula SchwabInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, 70210, Kuopio, Finland.
Jussi PihlajamäkiInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, 70210, Kuopio, Finland.

Funding

Academy of Finland 138006Academy of Finland 309311Itä-Suomen Yliopisto KärkihankeMatti Uusitupa Foundation juhlaseminaarirahastoNovo Nordisk Fonden NNF15CC0018486
6 · The paper itself

Abstract

purposeFatty acid desaturase (FADS) variants associate with fatty acid (FA) and adipose tissue (AT) metabolism and inflammation. Thus, the role of FADS1 variants in the regulation of dietary linoleic acid (LA)-induced effects on AT inflammation was investigated.

methodsSubjects homozygotes for the TT and CC genotypes of the FADS1-rs174550 (TT, n = 25 and CC, n = 28) or -rs174547 (TT, n = 42 and CC, n = 28), were either recruited from the METabolic Syndrome In Men cohort to participate in an intervention with LA-enriched diet (FADSDIET) or from the Kuopio Obesity Surgery (KOBS) study. GC and LC-MS for plasma FA proportions and eicosanoid concentrations and AT gene expression for AT inflammatory score (AT-InSc) was determined.

resultsWe observed a diet-genotype interaction between LA-enriched diet and AT-InSc in the FADSDIET. In the KOBS study, interleukin (IL)1 beta mRNA expression in AT was increased in subjects with the TT genotype and highest LA proportion. In the FADSDIET, n-6/LA proportions correlated positively with AT-InSc in those with the TT genotype but not with the CC genotype after LA-enriched diet. Specifically, LA- and AA-derived pro-inflammatory eicosanoids related to CYP450/sEH-pathways correlated positively with AT-InSc in those with the TT genotype, whereas in those with the CC genotype, the negative correlations between pro-inflammatory eicosanoids and AT-InSc related to COX/LOX-pathways.

conclusionsLA-enriched diet increases inflammatory AT gene expression in subjects with the TT genotype, while CC genotype could play a protective role against LA-induced AT inflammation. Overall, the FADS1 variant could modify the dietary LA-induced effects on AT inflammation through the differential biosynthesis of AA-derived eicosanoids.

Indexed as

Adipose TissueDelta-5 Fatty Acid DesaturaseDietEicosanoidsInflammationLinoleic AcidFemaleGenotypeHumansMalePolymorphism, Single NucleotideDelta-5 Fatty Acid DesaturaseEicosanoidsFADS1 protein, humanLinoleic AcidAdipose tissueArachidonic acidEicosanoidFADS1InflammationLinoleic acid

Identifiers

PMID35701670
PMCPMC9464166

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.