ArticleMolecular psychiatry2022
Sleep, physical activity, sedentary behavior, and risk of incident dementia: a prospective cohort study of 431,924 UK Biobank participants.
Article in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
66 citing papers in PubMed, 3 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Long-term physical activity, brain structure, and cognitive function: a systematic review of longitudinal observational evidence.BMC neurology · 2026Pooled it
- Pooled it
- Individual sedentary activities and cognitive function in middle-aged and older adults: A systematic review.Journal of Alzheimer's disease : JAD · 2026Pooled it
- Baseline cognition and demographic, lifestyle, and cardiovascular risk factors in US POINTER.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- Micro-bursts matter: vigorous intermittent lifestyle physical activity and risk of common brain disorders in a prospective cohort study.The international journal of behavioral nutrition and physical activity · 2026Article
- Activity profiles and their associations with transitions between fall and dementia: findings from a multistate time-to-event analysis.Alzheimer's research & therapy · 2026Article
- Digital Sleep-Wake Cycle Metrics and Dementia Prediction in Older Adults.JAMA neurology · 2026Article
- Association of sleep duration with Alzheimer's disease and cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Multicomponent Behavior Change Technique Intervention for Caregivers of People With Alzheimer Disease and Related Dementias: Protocol for a Single-Arm, Personalized Behavioral Trial to Disrupt Sedentary Time.JMIR research protocols · 2026Article
- Associations of accelerometry-derived time in major activity intensities with cognitive outcomes: a compositional data analysis approach.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Association between grip strength and walking pace with incidence of degenerative cervical myelopathy: a UK biobank observational study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Observational
- APOE ε4 and amyloid status moderate the associations between sleep, physical activity, and tau-PET burden in cognitively unimpaired older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Physical activity, falls, and dementia risk in adults aged ≥ 60: evidence from three cohorts.The international journal of behavioral nutrition and physical activity · 2026Article
- Associations of oral contraceptives and hormone replacement therapy with incident dementia risk: a population-based cohort study.Translational psychiatry · 2026Article
- Independent associations and isotemporal substitution analysis of 24-hour movement behaviors and depression among Chinese older adults.BMC psychology · 2026Article
- Healthy lifestyle and Alzheimer's disease in individuals with hyperlipidemia: A prospective cohort study.The journal of prevention of Alzheimer's disease · 2026Article
- Associations of sleep, sedentary behavior, and physical activity with incident migraine: a prospective cohort study.BMC public health · 2026Article
- Accelerometer-measured physical activity, sedentary behavior, and incident neuropsychiatric diseases: a large prospective cohort study of 73411 participants.Molecular psychiatry · 2026Article
- Excessive sleep duration increases the risk of dementia among older Chinese adults: evidence from the CLHLS.BMC geriatrics · 2026Article
- Unravelling the Connection Between Reduced Mobility and Mild Cognitive Impairment in Chronic Pain Patients Through Cluster Analysis.Advances in experimental medicine and biology · 2026Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 3 countries.
Funding
Abstract
Although sleep, physical activity and sedentary behavior have been found to be associated with dementia risk, findings are inconsistent and their joint relationship remains unclear. This study aimed to investigate independent and joint associations of these three modifiable behaviors with dementia risks. A total of 431,924 participants (median follow-up 9.0 years) without dementia from UK Biobank were included. Multiple Cox regressions were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Models fitted with restricted cubic spline were conducted to test for linear and nonlinear shapes of each association. Sleep duration, leisure-time physical activity (LTPA), and screen-based sedentary behavior individually associated with dementia risks in different non-linear patterns. Sleep duration associated with dementia in a U-shape with a nadir at 7 h/day. LTPA revealed a curvilinear relationship with dementia in diminishing tendency, while sedentary behavior revealed a J-shaped relationship. The dementia risk was 17% lower in the high LTPA group (HR[95%CI]: 0.83[0.76-0.91]) and 22% higher in the high sedentary behavior group (1.22[1.10-1.35]) compared to the corresponding low-level group, respectively. A combination of seven-hour/day sleep, moderate-to-high LTPA, and low-to-moderate sedentary behavior showed the lowest dementia risk (0.59[0.50-0.69]) compared to the referent group (longer or shorter sleep/low LTPA/high sedentary behavior). Notably, each behavior was non-linearly associated with brain structures in a pattern similar to its association with dementia, suggesting they may affect dementia risk by affecting brain structures. Our findings highlight the potential to change these three daily behaviors individually and simultaneously to reduce the risk of dementia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.