ArticleScientific reports2022
Comparison of calcium-based technologies to remineralise enamel subsurface lesions using microradiography and microhardness.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Efficient enamel subsurface lesion remineralisation and dentine tubule occlusion by high concentration CPP-ACP: a randomised, cross-over in situ study.Scientific reports · 2025Trial
- Calcium Hypophosphite: A New Active Ingredient for Biomimetic Oral Care.Biomimetics (Basel, Switzerland) · 2026Review
- Evaluation of the effects of different remineralizing agents on the microhardness and mineral content of bleached enamel along different storage times.BMC oral health · 2026Article
- Aspartic acid-facilitated remineralization: a bio-inspired alternative to fluoride for enamel repair.Frontiers in bioengineering and biotechnology · 2026Article
- In Vitro Evaluation of the Effects of Toothpastes and Color Correctors on the Surface Integrity of Demineralized Human Enamel.Dentistry journal · 2025Article
- Effect of Novel Etching System on Etch Pattern in Primary Teeth: AnInternational journal of clinical pediatric dentistry · 2025Article
- Article
- Casein Phosphopeptide-Amorphous Calcium Phosphate and Gallic Acid as a Complementary Approach for the Treatment of Early Enamel Lesions.International journal of biomaterials · 2025Article
- Assessment of the Remineralizing Potential of Biomimetic Materials on Early Artificial Caries Lesions after 28 Days: An In Vitro Study.Bioengineering (Basel, Switzerland) · 2023Article
- The remineralization effect of GERM CLEAN on early human enamel caries lesions in vitro.Scientific reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Assessment of enamel subsurface lesion remineralisation is essential for the evaluation of novel remineralisation technologies. The gold standard to assess subsurface mineral gain of enamel lesions is transverse microradiography (TMR). However, some studies have utilised surface microhardness (SMH) to evaluate efficacy of remineralisation agents. The aim of this study was to assess remineralisation of enamel subsurface lesions using TMR and SMH after in vitro treatment with calcium-containing technologies, and to test correlation between the TMR and SMH measurements. The parameters obtained from the TMR and SMH analyses of enamel subsurface remineralisation were not significantly correlated. Furthermore, the enamel subsurface remineralisation as measured by TMR was significantly correlated with the water-soluble calcium concentration of the remineralisation products. Scanning electron microscopy revealed surface precipitates formed by specific remineralisation treatments obfuscated accurate assessment of remineralisation by SMH. It was concluded that TMR is a more appropriate method for analysis of enamel subsurface remineralisation, and that SMH values of remineralised enamel should be interpreted with caution. Using TMR the level of remineralisation (%R) by the different technologies was CPP-ACP/F (31.3 ± 1.4%); CPP-ACP (24.2 ± 1.4%); CaSO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.