Evidence map›Paper›PMID 35701487›Full record

ArticleCommunications biology2022

Heart rate and age modulate retinal pulsatile patterns.

Ivana Labounková, René Labounek, Radim Kolář, Ralf P Tornow, Charles F Babbs, Collin M McClelland, Benjamin R Miller, Igor Nestrašil

Abstract read
In one paragraph

Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ivana LabounkováDepartment of Biomedical Engineering, Brno University of Technology, Brno, Czech Republic.ORCID 0000-0002-3754-7566
René LabounekDivision of Clinical Behavioral Neuroscience, Department of Pediatrics, Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0003-0439-1304
Radim KolářDepartment of Biomedical Engineering, Brno University of Technology, Brno, Czech Republic.
Ralf P TornowDepartment of Ophthalmology, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.ORCID 0000-0003-2401-3618
Charles F BabbsWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Collin M McClellandDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA.
Benjamin R MillerDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-9988-9687
Igor NestrašilDivision of Clinical Behavioral Neuroscience, Department of Pediatrics, Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA. nestr007@umn.edu.ORCID 0000-0002-3833-1484

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Theoretical models of retinal hemodynamics showed the modulation of retinal pulsatile patterns (RPPs) by heart rate (HR), yet in-vivo validation and scientific merit of this biological process is lacking. Such evidence is critical for result interpretation, study design, and (patho-)physiological modeling of human biology spanning applications in various medical specialties. In retinal hemodynamic video-recordings, we characterize the morphology of RPPs and assess the impact of modulation by HR or other variables. Principal component analysis isolated two RPPs, i.e., spontaneous venous pulsation (SVP) and optic cup pulsation (OCP). Heart rate modulated SVP and OCP morphology (p

Indexed as

Optic DiskRetinal VeinHeart RateHumansIntraocular PressurePulsatile Flow

Identifiers

PMID35701487
PMCPMC9197857

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.