Evidence map›Paper›PMID 35701476›Full record

ArticleScientific data2022

A map of bat virus receptors derived from single-cell multiomics.

Tianhang Lv, Xiaoshan Wang, Chao Yu, Zhifeng Wang, Rong Xiang, Linmiao Li, Yue Yuan, Yuhang Wang, Xiaoyu Wei, Yeya Yu and 9 more

Abstract readDataset
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific data, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Tianhang Lv *College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
Xiaoshan Wang *BGI-Shenzhen, Shenzhen, 518083, China.
Chao Yu *CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China.
Zhifeng Wang *BGI-Shenzhen, Shenzhen, 518083, China.
Rong Xiang *College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
Linmiao LiGuangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou, 510260, China.
Yue YuanCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
Yuhang WangBGI-Shenzhen, Shenzhen, 518083, China.ORCID 0000-0001-6804-0445
Xiaoyu WeiCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
Yeya YuBGI-Shenzhen, Shenzhen, 518083, China.
Xiangyang HeGuangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou, 510260, China.
Libiao ZhangGuangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou, 510260, China.
Qiuting DengCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
Peiying WuBGI-Shenzhen, Shenzhen, 518083, China.
Yong HouBGI-Shenzhen, Shenzhen, 518083, China.
Jinping ChenGuangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou, 510260, China. chenjp@giz.gd.cn.
Chuanyu LiuBGI-Shenzhen, Shenzhen, 518083, China. liuchuanyu@genomics.cn.ORCID 0000-0003-2258-0897
Gary WongCAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China. garyckwong@ips.ac.cn.ORCID 0000-0002-9044-8153
Longqi LiuBGI-Shenzhen, Shenzhen, 518083, China. liulongqi@genomics.cn.ORCID 0000-0002-5828-5542

Funding

China Postdoctoral Science Foundation 2020T130080ZXChina Postdoctoral Science Foundation 2021M702280National Natural Science Foundation of China (National Science Foundation of China) 31900466
6 · The paper itself

Abstract

Bats are considered reservoirs of many lethal zoonotic viruses and have been implicated in several outbreaks of emerging infectious diseases, such as SARS-CoV, MERS-CoV, and SARS-CoV-2. It is necessary to systematically derive the expression patterns of bat virus receptors and their regulatory features for future research into bat-borne viruses and the prediction and prevention of pandemics. Here, we performed single-nucleus RNA sequencing (snRNA-seq) and single-nucleus assay for transposase-accessible chromatin using sequencing (snATAC-seq) of major organ samples collected from Chinese horseshoe bats (Rhinolophus affinis) and systematically checked the expression pattern of bat-related virus receptors and chromatin accessibility across organs and cell types, providing a valuable dataset for studying the nature of infection among bat-borne viruses.

Indexed as

ChiropteraCOVID-19Receptors, VirusSARS-CoV-2AnimalsGenome, ViralHumansPhylogenySingle-Cell AnalysisReceptors, Virus

Identifiers

PMID35701476
PMCPMC9195401

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.