Evidence map›Paper›PMID 35701447›Full record

ArticleScientific reports2022

A pilot study of micro-CT-based whole tissue imaging (WTI) on endoscopic submucosal dissection (ESD) specimens.

Hirotsugu Sakamoto, Makoto Nishimura, Alexei Teplov, Galen Leung, Peter Ntiamoah, Emine Cesmecioglu, Noboru Kawata, Takashi Ohnishi, Ibrahim Kareem, Jinru Shia and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Machine learning methods for histopathological image analysis: Updates in 2024.Computational and structural biotechnology journal · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hirotsugu SakamotoDepartment of Pathology, Memorial Sloan Kettering Cancer Center, MSKCC Josie Robertson Surgery Center, 1133 York Ave. Suite 1020, New York, NY, 10065, USA. 94036hs@jichi.ac.jp.
Makoto NishimuraGastroenterology, Hepatology and Nutrition Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Alexei TeplovDepartment of Pathology, Memorial Sloan Kettering Cancer Center, MSKCC Josie Robertson Surgery Center, 1133 York Ave. Suite 1020, New York, NY, 10065, USA.
Galen LeungGastroenterology, Hepatology and Nutrition Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Peter NtiamoahDepartment of Pathology, Memorial Sloan Kettering Cancer Center, MSKCC Josie Robertson Surgery Center, 1133 York Ave. Suite 1020, New York, NY, 10065, USA.
Emine CesmeciogluDepartment of Pathology, Memorial Sloan Kettering Cancer Center, MSKCC Josie Robertson Surgery Center, 1133 York Ave. Suite 1020, New York, NY, 10065, USA.
Noboru KawataDepartment of Pathology, Memorial Sloan Kettering Cancer Center, MSKCC Josie Robertson Surgery Center, 1133 York Ave. Suite 1020, New York, NY, 10065, USA.
Takashi OhnishiDepartment of Pathology, Memorial Sloan Kettering Cancer Center, MSKCC Josie Robertson Surgery Center, 1133 York Ave. Suite 1020, New York, NY, 10065, USA.
Ibrahim KareemDepartment of Pathology, Memorial Sloan Kettering Cancer Center, MSKCC Josie Robertson Surgery Center, 1133 York Ave. Suite 1020, New York, NY, 10065, USA.
Jinru ShiaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, MSKCC Josie Robertson Surgery Center, 1133 York Ave. Suite 1020, New York, NY, 10065, USA.
Yukako YagiDepartment of Pathology, Memorial Sloan Kettering Cancer Center, MSKCC Josie Robertson Surgery Center, 1133 York Ave. Suite 1020, New York, NY, 10065, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Endoscopic submucosal dissection can remove large superficial gastrointestinal lesions in en bloc. A detailed pathological evaluation of the resected specimen is required to assess the risk of recurrence after treatment. However, the current method of sectioning specimens to a thickness of a few millimeters does not provide information between the sections that are lost during the preparation. In this study, we have produced three-dimensional images of the entire dissected lesion for nine samples by using micro-CT imaging system. Although it was difficult to diagnose histological type on micro-CT images, it successfully evaluates the extent of the lesion and its surgical margins. Micro-CT images can depict sites that cannot be observed by the conventional pathological diagnostic process, suggesting that it may be useful to use in a complementary manner.

Indexed as

Endoscopic Mucosal ResectionHumansMargins of ExcisionPilot ProjectsTreatment OutcomeX-Ray Microtomography

Identifiers

PMID35701447
PMCPMC9198046

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.