ArticleNeurology(R) neuroimmunology & neuroinflammation2022
Early Reduction of MRI Activity During 6 Months of Treatment With Cladribine Tablets for Highly Active Relapsing Multiple Sclerosis: MAGNIFY-MS.
Erratum issued Registry-linked trialAbstract read
In one paragraph
Article in Neurology(R) neuroimmunology & neuroinflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03364036 (A 2-year Prospective Study to Evaluate the Onset of Action of Mavenclad® in Subjects With Highly Active Relapsing Multiple Sclerosis), which is not on this map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A 2-year Prospective Study to Evaluate the Onset of Action of Mavenclad® in Subjects With Highly Active Relapsing Multiple Sclerosis (MAGNIFY)
Who cites it
20 citing papers in PubMed.
- Blood biomarker dynamics in people with relapsing multiple sclerosis treated with cladribine tablets: results of the 2-year MAGNIFY-MS study.Frontiers in immunology · 2025Trial
- Simultaneous TMagnetic resonance in medicine · 2026Article
- International Expert Opinion on Optimal Switching to Cladribine Tablets from Other High-Efficacy Disease-Modifying Therapies for Relapsing-Remitting Multiple Sclerosis: Opportunities and Challenges.Neurology and therapy · 2026Review
- Inflammation and Immunomodulation in Cerebral X-linked Adrenoleukodystrophy: Review of Pathology and Interventions.Journal of child neurology · 2026Review
- Insights into adherence to cladribine tablets in the real world in multiple countries: results from patient support programs.Therapeutic advances in neurological disorders · 2026Article
- A drug evaluation narrative review of cladribine as a treatment for multiple sclerosis.Neurodegenerative disease management · 2025Review
- The Italian Multiple Sclerosis Register Experience With Cladribine: Impact on Relapses, PIRA, and Treatment Sequencing Strategies Evaluation.Neurology(R) neuroimmunology & neuroinflammation · 2025Article
- Cladribine tablets in the new multiple sclerosis era.Therapeutic advances in neurological disorders · 2025Review
- Clinical and mechanistic effects of cladribine in relapsing multiple sclerosis: 2-year results from the MAGNIFY-MS Study.Therapeutic advances in neurological disorders · 2025Article
- Making Information About Cladribine Tablets Accessible to People with Multiple Sclerosis: A Patient-Survey-Led Narrative Review for Healthcare Professionals.Neurology and therapy · 2024Review
- Holistic, Long-Term Management of People with Relapsing Multiple Sclerosis with Cladribine Tablets: Expert Opinion from France.Neurology and therapy · 2024Review
- Magnetic Resonance Imaging Evidence Supporting the Efficacy of Cladribine Tablets in the Treatment of Relapsing-Remitting Multiple Sclerosis.CNS drugs · 2024Review
- Real-World Effectiveness of Cladribine for Patients with Multiple Sclerosis: A Sicilian Multicentric Experience (Rewind Study).Current neuropharmacology · 2024Article
- Effectiveness and safety profile of cladribine in an Italian real-life cohort of relapsing-remitting multiple sclerosis patients: a monocentric longitudinal observational study.Journal of neurology · 2023Observational
- Accelerated Simultaneous TTomography (Ann Arbor, Mich.) · 2023Article
- Specific Patterns of Immune Cell Dynamics May Explain the Early Onset and Prolonged Efficacy of Cladribine Tablets: A MAGNIFY-MS Substudy.Neurology(R) neuroimmunology & neuroinflammation · 2023Article
- Disease activity 4.5 years after starting cladribine: experience in 264 patients with multiple sclerosis.Therapeutic advances in neurological disorders · 2023Article
- Early Reduction of MRI Activity During 6 Months of Cladribine Tablet Treatment for Highly Active Relapsing Multiple Sclerosis: MAGNIFY-MS.Neurology(R) neuroimmunology & neuroinflammation · 2022Article
- Emerging therapies to target CNS pathophysiology in multiple sclerosis.Nature reviews. Neurology · 2022Review
- Early clinical effect of cladribine in patients with highly active multiple sclerosis in Mexico.Multiple sclerosis journal - experimental, translational and clinicalArticle
Corrections and comments
- Erratum issued
Authors and funding
16 authors.
Nicola de StefanoFrom the Department of Medicine (N.S.), Surgery and Neuroscience, University of Siena, Siena, Italy; Department of Radiology (F.B.), VU University Medical Center, Amsterdam, The Netherlands; UCL Institute of Neurology (F.B.), London, UK; Department of Neurology-Neuroimmunology (X.M.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitario Vall d'Hebron, Universitat Autonoma de Barcelona, Spain; Multiple Sclerosis Center (A.A.), Sheba Academic Medical Center, Ramat Gan, Israel; Department of Neurology (T.D.), University Hospital Basel, Switzerland; Department of Neurology (A.C.), Inselspital, Bern University Hospital, University of Bern, Switzerland; Ingham Institute for Applied Medical Research (S.H.), University of New South Wales Medicine, Sydney, Australia; Department of Neurosciences (A.P.), Université de Montréal, QC, Canada; Experimental Neurophysiology Unit (L.L.), Vita-Salute San Raffaele University, Milan, Italy; The Blizard Institute (K.S.), Centre for Neuroscience, Surgery & Trauma, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, UK and; Clinical Board Medicine (Neuroscience) (K.S.), The Royal London Hospital, Barts Health NHS Trust, UK; Danish MS Center (F.S.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine (F.S.), University of Copenhagen, Denmark; Univ. Lille (P.V.), Inserm U1172 LilNCog, CHU Lille, FHU Precise, France; Department of Neurology (H.W.), Institute of Translational Neurology, University of Münster, Germany; the healthcare business of Merck KGaA (B.K.), Darmstadt, Germany; and Ares Trading S.A. (S.R.), Eysins, Switzerland (an affiliate of Merck KGaA, Darmstadt, Germany). destefano@unisi.it.ORCID 0000-0003-4930-7639
Frederik BarkhofFrom the Department of Medicine (N.S.), Surgery and Neuroscience, University of Siena, Siena, Italy; Department of Radiology (F.B.), VU University Medical Center, Amsterdam, The Netherlands; UCL Institute of Neurology (F.B.), London, UK; Department of Neurology-Neuroimmunology (X.M.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitario Vall d'Hebron, Universitat Autonoma de Barcelona, Spain; Multiple Sclerosis Center (A.A.), Sheba Academic Medical Center, Ramat Gan, Israel; Department of Neurology (T.D.), University Hospital Basel, Switzerland; Department of Neurology (A.C.), Inselspital, Bern University Hospital, University of Bern, Switzerland; Ingham Institute for Applied Medical Research (S.H.), University of New South Wales Medicine, Sydney, Australia; Department of Neurosciences (A.P.), Université de Montréal, QC, Canada; Experimental Neurophysiology Unit (L.L.), Vita-Salute San Raffaele University, Milan, Italy; The Blizard Institute (K.S.), Centre for Neuroscience, Surgery & Trauma, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, UK and; Clinical Board Medicine (Neuroscience) (K.S.), The Royal London Hospital, Barts Health NHS Trust, UK; Danish MS Center (F.S.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine (F.S.), University of Copenhagen, Denmark; Univ. Lille (P.V.), Inserm U1172 LilNCog, CHU Lille, FHU Precise, France; Department of Neurology (H.W.), Institute of Translational Neurology, University of Münster, Germany; the healthcare business of Merck KGaA (B.K.), Darmstadt, Germany; and Ares Trading S.A. (S.R.), Eysins, Switzerland (an affiliate of Merck KGaA, Darmstadt, Germany).ORCID 0000-0003-3543-3706
Xavier MontalbanFrom the Department of Medicine (N.S.), Surgery and Neuroscience, University of Siena, Siena, Italy; Department of Radiology (F.B.), VU University Medical Center, Amsterdam, The Netherlands; UCL Institute of Neurology (F.B.), London, UK; Department of Neurology-Neuroimmunology (X.M.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitario Vall d'Hebron, Universitat Autonoma de Barcelona, Spain; Multiple Sclerosis Center (A.A.), Sheba Academic Medical Center, Ramat Gan, Israel; Department of Neurology (T.D.), University Hospital Basel, Switzerland; Department of Neurology (A.C.), Inselspital, Bern University Hospital, University of Bern, Switzerland; Ingham Institute for Applied Medical Research (S.H.), University of New South Wales Medicine, Sydney, Australia; Department of Neurosciences (A.P.), Université de Montréal, QC, Canada; Experimental Neurophysiology Unit (L.L.), Vita-Salute San Raffaele University, Milan, Italy; The Blizard Institute (K.S.), Centre for Neuroscience, Surgery & Trauma, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, UK and; Clinical Board Medicine (Neuroscience) (K.S.), The Royal London Hospital, Barts Health NHS Trust, UK; Danish MS Center (F.S.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine (F.S.), University of Copenhagen, Denmark; Univ. Lille (P.V.), Inserm U1172 LilNCog, CHU Lille, FHU Precise, France; Department of Neurology (H.W.), Institute of Translational Neurology, University of Münster, Germany; the healthcare business of Merck KGaA (B.K.), Darmstadt, Germany; and Ares Trading S.A. (S.R.), Eysins, Switzerland (an affiliate of Merck KGaA, Darmstadt, Germany).ORCID 0000-0002-0098-9918
Anat AchironFrom the Department of Medicine (N.S.), Surgery and Neuroscience, University of Siena, Siena, Italy; Department of Radiology (F.B.), VU University Medical Center, Amsterdam, The Netherlands; UCL Institute of Neurology (F.B.), London, UK; Department of Neurology-Neuroimmunology (X.M.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitario Vall d'Hebron, Universitat Autonoma de Barcelona, Spain; Multiple Sclerosis Center (A.A.), Sheba Academic Medical Center, Ramat Gan, Israel; Department of Neurology (T.D.), University Hospital Basel, Switzerland; Department of Neurology (A.C.), Inselspital, Bern University Hospital, University of Bern, Switzerland; Ingham Institute for Applied Medical Research (S.H.), University of New South Wales Medicine, Sydney, Australia; Department of Neurosciences (A.P.), Université de Montréal, QC, Canada; Experimental Neurophysiology Unit (L.L.), Vita-Salute San Raffaele University, Milan, Italy; The Blizard Institute (K.S.), Centre for Neuroscience, Surgery & Trauma, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, UK and; Clinical Board Medicine (Neuroscience) (K.S.), The Royal London Hospital, Barts Health NHS Trust, UK; Danish MS Center (F.S.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine (F.S.), University of Copenhagen, Denmark; Univ. Lille (P.V.), Inserm U1172 LilNCog, CHU Lille, FHU Precise, France; Department of Neurology (H.W.), Institute of Translational Neurology, University of Münster, Germany; the healthcare business of Merck KGaA (B.K.), Darmstadt, Germany; and Ares Trading S.A. (S.R.), Eysins, Switzerland (an affiliate of Merck KGaA, Darmstadt, Germany).ORCID 0000-0002-2020-3126
Tobias DerfussFrom the Department of Medicine (N.S.), Surgery and Neuroscience, University of Siena, Siena, Italy; Department of Radiology (F.B.), VU University Medical Center, Amsterdam, The Netherlands; UCL Institute of Neurology (F.B.), London, UK; Department of Neurology-Neuroimmunology (X.M.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitario Vall d'Hebron, Universitat Autonoma de Barcelona, Spain; Multiple Sclerosis Center (A.A.), Sheba Academic Medical Center, Ramat Gan, Israel; Department of Neurology (T.D.), University Hospital Basel, Switzerland; Department of Neurology (A.C.), Inselspital, Bern University Hospital, University of Bern, Switzerland; Ingham Institute for Applied Medical Research (S.H.), University of New South Wales Medicine, Sydney, Australia; Department of Neurosciences (A.P.), Université de Montréal, QC, Canada; Experimental Neurophysiology Unit (L.L.), Vita-Salute San Raffaele University, Milan, Italy; The Blizard Institute (K.S.), Centre for Neuroscience, Surgery & Trauma, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, UK and; Clinical Board Medicine (Neuroscience) (K.S.), The Royal London Hospital, Barts Health NHS Trust, UK; Danish MS Center (F.S.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine (F.S.), University of Copenhagen, Denmark; Univ. Lille (P.V.), Inserm U1172 LilNCog, CHU Lille, FHU Precise, France; Department of Neurology (H.W.), Institute of Translational Neurology, University of Münster, Germany; the healthcare business of Merck KGaA (B.K.), Darmstadt, Germany; and Ares Trading S.A. (S.R.), Eysins, Switzerland (an affiliate of Merck KGaA, Darmstadt, Germany).ORCID 0000-0001-8431-8769
Andrew ChanFrom the Department of Medicine (N.S.), Surgery and Neuroscience, University of Siena, Siena, Italy; Department of Radiology (F.B.), VU University Medical Center, Amsterdam, The Netherlands; UCL Institute of Neurology (F.B.), London, UK; Department of Neurology-Neuroimmunology (X.M.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitario Vall d'Hebron, Universitat Autonoma de Barcelona, Spain; Multiple Sclerosis Center (A.A.), Sheba Academic Medical Center, Ramat Gan, Israel; Department of Neurology (T.D.), University Hospital Basel, Switzerland; Department of Neurology (A.C.), Inselspital, Bern University Hospital, University of Bern, Switzerland; Ingham Institute for Applied Medical Research (S.H.), University of New South Wales Medicine, Sydney, Australia; Department of Neurosciences (A.P.), Université de Montréal, QC, Canada; Experimental Neurophysiology Unit (L.L.), Vita-Salute San Raffaele University, Milan, Italy; The Blizard Institute (K.S.), Centre for Neuroscience, Surgery & Trauma, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, UK and; Clinical Board Medicine (Neuroscience) (K.S.), The Royal London Hospital, Barts Health NHS Trust, UK; Danish MS Center (F.S.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine (F.S.), University of Copenhagen, Denmark; Univ. Lille (P.V.), Inserm U1172 LilNCog, CHU Lille, FHU Precise, France; Department of Neurology (H.W.), Institute of Translational Neurology, University of Münster, Germany; the healthcare business of Merck KGaA (B.K.), Darmstadt, Germany; and Ares Trading S.A. (S.R.), Eysins, Switzerland (an affiliate of Merck KGaA, Darmstadt, Germany).
Suzanne HodgkinsonFrom the Department of Medicine (N.S.), Surgery and Neuroscience, University of Siena, Siena, Italy; Department of Radiology (F.B.), VU University Medical Center, Amsterdam, The Netherlands; UCL Institute of Neurology (F.B.), London, UK; Department of Neurology-Neuroimmunology (X.M.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitario Vall d'Hebron, Universitat Autonoma de Barcelona, Spain; Multiple Sclerosis Center (A.A.), Sheba Academic Medical Center, Ramat Gan, Israel; Department of Neurology (T.D.), University Hospital Basel, Switzerland; Department of Neurology (A.C.), Inselspital, Bern University Hospital, University of Bern, Switzerland; Ingham Institute for Applied Medical Research (S.H.), University of New South Wales Medicine, Sydney, Australia; Department of Neurosciences (A.P.), Université de Montréal, QC, Canada; Experimental Neurophysiology Unit (L.L.), Vita-Salute San Raffaele University, Milan, Italy; The Blizard Institute (K.S.), Centre for Neuroscience, Surgery & Trauma, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, UK and; Clinical Board Medicine (Neuroscience) (K.S.), The Royal London Hospital, Barts Health NHS Trust, UK; Danish MS Center (F.S.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine (F.S.), University of Copenhagen, Denmark; Univ. Lille (P.V.), Inserm U1172 LilNCog, CHU Lille, FHU Precise, France; Department of Neurology (H.W.), Institute of Translational Neurology, University of Münster, Germany; the healthcare business of Merck KGaA (B.K.), Darmstadt, Germany; and Ares Trading S.A. (S.R.), Eysins, Switzerland (an affiliate of Merck KGaA, Darmstadt, Germany).ORCID 0000-0002-9029-6663
Alexandre PratFrom the Department of Medicine (N.S.), Surgery and Neuroscience, University of Siena, Siena, Italy; Department of Radiology (F.B.), VU University Medical Center, Amsterdam, The Netherlands; UCL Institute of Neurology (F.B.), London, UK; Department of Neurology-Neuroimmunology (X.M.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitario Vall d'Hebron, Universitat Autonoma de Barcelona, Spain; Multiple Sclerosis Center (A.A.), Sheba Academic Medical Center, Ramat Gan, Israel; Department of Neurology (T.D.), University Hospital Basel, Switzerland; Department of Neurology (A.C.), Inselspital, Bern University Hospital, University of Bern, Switzerland; Ingham Institute for Applied Medical Research (S.H.), University of New South Wales Medicine, Sydney, Australia; Department of Neurosciences (A.P.), Université de Montréal, QC, Canada; Experimental Neurophysiology Unit (L.L.), Vita-Salute San Raffaele University, Milan, Italy; The Blizard Institute (K.S.), Centre for Neuroscience, Surgery & Trauma, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, UK and; Clinical Board Medicine (Neuroscience) (K.S.), The Royal London Hospital, Barts Health NHS Trust, UK; Danish MS Center (F.S.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine (F.S.), University of Copenhagen, Denmark; Univ. Lille (P.V.), Inserm U1172 LilNCog, CHU Lille, FHU Precise, France; Department of Neurology (H.W.), Institute of Translational Neurology, University of Münster, Germany; the healthcare business of Merck KGaA (B.K.), Darmstadt, Germany; and Ares Trading S.A. (S.R.), Eysins, Switzerland (an affiliate of Merck KGaA, Darmstadt, Germany).ORCID 0000-0001-6188-0580
Letizia LeocaniFrom the Department of Medicine (N.S.), Surgery and Neuroscience, University of Siena, Siena, Italy; Department of Radiology (F.B.), VU University Medical Center, Amsterdam, The Netherlands; UCL Institute of Neurology (F.B.), London, UK; Department of Neurology-Neuroimmunology (X.M.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitario Vall d'Hebron, Universitat Autonoma de Barcelona, Spain; Multiple Sclerosis Center (A.A.), Sheba Academic Medical Center, Ramat Gan, Israel; Department of Neurology (T.D.), University Hospital Basel, Switzerland; Department of Neurology (A.C.), Inselspital, Bern University Hospital, University of Bern, Switzerland; Ingham Institute for Applied Medical Research (S.H.), University of New South Wales Medicine, Sydney, Australia; Department of Neurosciences (A.P.), Université de Montréal, QC, Canada; Experimental Neurophysiology Unit (L.L.), Vita-Salute San Raffaele University, Milan, Italy; The Blizard Institute (K.S.), Centre for Neuroscience, Surgery & Trauma, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, UK and; Clinical Board Medicine (Neuroscience) (K.S.), The Royal London Hospital, Barts Health NHS Trust, UK; Danish MS Center (F.S.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine (F.S.), University of Copenhagen, Denmark; Univ. Lille (P.V.), Inserm U1172 LilNCog, CHU Lille, FHU Precise, France; Department of Neurology (H.W.), Institute of Translational Neurology, University of Münster, Germany; the healthcare business of Merck KGaA (B.K.), Darmstadt, Germany; and Ares Trading S.A. (S.R.), Eysins, Switzerland (an affiliate of Merck KGaA, Darmstadt, Germany).ORCID 0000-0001-9326-6753
Klaus SchmiererFrom the Department of Medicine (N.S.), Surgery and Neuroscience, University of Siena, Siena, Italy; Department of Radiology (F.B.), VU University Medical Center, Amsterdam, The Netherlands; UCL Institute of Neurology (F.B.), London, UK; Department of Neurology-Neuroimmunology (X.M.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitario Vall d'Hebron, Universitat Autonoma de Barcelona, Spain; Multiple Sclerosis Center (A.A.), Sheba Academic Medical Center, Ramat Gan, Israel; Department of Neurology (T.D.), University Hospital Basel, Switzerland; Department of Neurology (A.C.), Inselspital, Bern University Hospital, University of Bern, Switzerland; Ingham Institute for Applied Medical Research (S.H.), University of New South Wales Medicine, Sydney, Australia; Department of Neurosciences (A.P.), Université de Montréal, QC, Canada; Experimental Neurophysiology Unit (L.L.), Vita-Salute San Raffaele University, Milan, Italy; The Blizard Institute (K.S.), Centre for Neuroscience, Surgery & Trauma, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, UK and; Clinical Board Medicine (Neuroscience) (K.S.), The Royal London Hospital, Barts Health NHS Trust, UK; Danish MS Center (F.S.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine (F.S.), University of Copenhagen, Denmark; Univ. Lille (P.V.), Inserm U1172 LilNCog, CHU Lille, FHU Precise, France; Department of Neurology (H.W.), Institute of Translational Neurology, University of Münster, Germany; the healthcare business of Merck KGaA (B.K.), Darmstadt, Germany; and Ares Trading S.A. (S.R.), Eysins, Switzerland (an affiliate of Merck KGaA, Darmstadt, Germany).ORCID 0000-0002-9293-8893
Finn SellebjergFrom the Department of Medicine (N.S.), Surgery and Neuroscience, University of Siena, Siena, Italy; Department of Radiology (F.B.), VU University Medical Center, Amsterdam, The Netherlands; UCL Institute of Neurology (F.B.), London, UK; Department of Neurology-Neuroimmunology (X.M.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitario Vall d'Hebron, Universitat Autonoma de Barcelona, Spain; Multiple Sclerosis Center (A.A.), Sheba Academic Medical Center, Ramat Gan, Israel; Department of Neurology (T.D.), University Hospital Basel, Switzerland; Department of Neurology (A.C.), Inselspital, Bern University Hospital, University of Bern, Switzerland; Ingham Institute for Applied Medical Research (S.H.), University of New South Wales Medicine, Sydney, Australia; Department of Neurosciences (A.P.), Université de Montréal, QC, Canada; Experimental Neurophysiology Unit (L.L.), Vita-Salute San Raffaele University, Milan, Italy; The Blizard Institute (K.S.), Centre for Neuroscience, Surgery & Trauma, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, UK and; Clinical Board Medicine (Neuroscience) (K.S.), The Royal London Hospital, Barts Health NHS Trust, UK; Danish MS Center (F.S.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine (F.S.), University of Copenhagen, Denmark; Univ. Lille (P.V.), Inserm U1172 LilNCog, CHU Lille, FHU Precise, France; Department of Neurology (H.W.), Institute of Translational Neurology, University of Münster, Germany; the healthcare business of Merck KGaA (B.K.), Darmstadt, Germany; and Ares Trading S.A. (S.R.), Eysins, Switzerland (an affiliate of Merck KGaA, Darmstadt, Germany).ORCID 0000-0002-1333-9623
Patrick VermerschFrom the Department of Medicine (N.S.), Surgery and Neuroscience, University of Siena, Siena, Italy; Department of Radiology (F.B.), VU University Medical Center, Amsterdam, The Netherlands; UCL Institute of Neurology (F.B.), London, UK; Department of Neurology-Neuroimmunology (X.M.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitario Vall d'Hebron, Universitat Autonoma de Barcelona, Spain; Multiple Sclerosis Center (A.A.), Sheba Academic Medical Center, Ramat Gan, Israel; Department of Neurology (T.D.), University Hospital Basel, Switzerland; Department of Neurology (A.C.), Inselspital, Bern University Hospital, University of Bern, Switzerland; Ingham Institute for Applied Medical Research (S.H.), University of New South Wales Medicine, Sydney, Australia; Department of Neurosciences (A.P.), Université de Montréal, QC, Canada; Experimental Neurophysiology Unit (L.L.), Vita-Salute San Raffaele University, Milan, Italy; The Blizard Institute (K.S.), Centre for Neuroscience, Surgery & Trauma, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, UK and; Clinical Board Medicine (Neuroscience) (K.S.), The Royal London Hospital, Barts Health NHS Trust, UK; Danish MS Center (F.S.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine (F.S.), University of Copenhagen, Denmark; Univ. Lille (P.V.), Inserm U1172 LilNCog, CHU Lille, FHU Precise, France; Department of Neurology (H.W.), Institute of Translational Neurology, University of Münster, Germany; the healthcare business of Merck KGaA (B.K.), Darmstadt, Germany; and Ares Trading S.A. (S.R.), Eysins, Switzerland (an affiliate of Merck KGaA, Darmstadt, Germany).ORCID 0000-0003-0997-8817
Heinz WiendlFrom the Department of Medicine (N.S.), Surgery and Neuroscience, University of Siena, Siena, Italy; Department of Radiology (F.B.), VU University Medical Center, Amsterdam, The Netherlands; UCL Institute of Neurology (F.B.), London, UK; Department of Neurology-Neuroimmunology (X.M.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitario Vall d'Hebron, Universitat Autonoma de Barcelona, Spain; Multiple Sclerosis Center (A.A.), Sheba Academic Medical Center, Ramat Gan, Israel; Department of Neurology (T.D.), University Hospital Basel, Switzerland; Department of Neurology (A.C.), Inselspital, Bern University Hospital, University of Bern, Switzerland; Ingham Institute for Applied Medical Research (S.H.), University of New South Wales Medicine, Sydney, Australia; Department of Neurosciences (A.P.), Université de Montréal, QC, Canada; Experimental Neurophysiology Unit (L.L.), Vita-Salute San Raffaele University, Milan, Italy; The Blizard Institute (K.S.), Centre for Neuroscience, Surgery & Trauma, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, UK and; Clinical Board Medicine (Neuroscience) (K.S.), The Royal London Hospital, Barts Health NHS Trust, UK; Danish MS Center (F.S.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine (F.S.), University of Copenhagen, Denmark; Univ. Lille (P.V.), Inserm U1172 LilNCog, CHU Lille, FHU Precise, France; Department of Neurology (H.W.), Institute of Translational Neurology, University of Münster, Germany; the healthcare business of Merck KGaA (B.K.), Darmstadt, Germany; and Ares Trading S.A. (S.R.), Eysins, Switzerland (an affiliate of Merck KGaA, Darmstadt, Germany).ORCID 0000-0003-4310-3432
Birgit KellerFrom the Department of Medicine (N.S.), Surgery and Neuroscience, University of Siena, Siena, Italy; Department of Radiology (F.B.), VU University Medical Center, Amsterdam, The Netherlands; UCL Institute of Neurology (F.B.), London, UK; Department of Neurology-Neuroimmunology (X.M.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitario Vall d'Hebron, Universitat Autonoma de Barcelona, Spain; Multiple Sclerosis Center (A.A.), Sheba Academic Medical Center, Ramat Gan, Israel; Department of Neurology (T.D.), University Hospital Basel, Switzerland; Department of Neurology (A.C.), Inselspital, Bern University Hospital, University of Bern, Switzerland; Ingham Institute for Applied Medical Research (S.H.), University of New South Wales Medicine, Sydney, Australia; Department of Neurosciences (A.P.), Université de Montréal, QC, Canada; Experimental Neurophysiology Unit (L.L.), Vita-Salute San Raffaele University, Milan, Italy; The Blizard Institute (K.S.), Centre for Neuroscience, Surgery & Trauma, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, UK and; Clinical Board Medicine (Neuroscience) (K.S.), The Royal London Hospital, Barts Health NHS Trust, UK; Danish MS Center (F.S.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine (F.S.), University of Copenhagen, Denmark; Univ. Lille (P.V.), Inserm U1172 LilNCog, CHU Lille, FHU Precise, France; Department of Neurology (H.W.), Institute of Translational Neurology, University of Münster, Germany; the healthcare business of Merck KGaA (B.K.), Darmstadt, Germany; and Ares Trading S.A. (S.R.), Eysins, Switzerland (an affiliate of Merck KGaA, Darmstadt, Germany).ORCID 0000-0001-6870-8003
Sanjeev RoyFrom the Department of Medicine (N.S.), Surgery and Neuroscience, University of Siena, Siena, Italy; Department of Radiology (F.B.), VU University Medical Center, Amsterdam, The Netherlands; UCL Institute of Neurology (F.B.), London, UK; Department of Neurology-Neuroimmunology (X.M.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitario Vall d'Hebron, Universitat Autonoma de Barcelona, Spain; Multiple Sclerosis Center (A.A.), Sheba Academic Medical Center, Ramat Gan, Israel; Department of Neurology (T.D.), University Hospital Basel, Switzerland; Department of Neurology (A.C.), Inselspital, Bern University Hospital, University of Bern, Switzerland; Ingham Institute for Applied Medical Research (S.H.), University of New South Wales Medicine, Sydney, Australia; Department of Neurosciences (A.P.), Université de Montréal, QC, Canada; Experimental Neurophysiology Unit (L.L.), Vita-Salute San Raffaele University, Milan, Italy; The Blizard Institute (K.S.), Centre for Neuroscience, Surgery & Trauma, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, UK and; Clinical Board Medicine (Neuroscience) (K.S.), The Royal London Hospital, Barts Health NHS Trust, UK; Danish MS Center (F.S.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine (F.S.), University of Copenhagen, Denmark; Univ. Lille (P.V.), Inserm U1172 LilNCog, CHU Lille, FHU Precise, France; Department of Neurology (H.W.), Institute of Translational Neurology, University of Münster, Germany; the healthcare business of Merck KGaA (B.K.), Darmstadt, Germany; and Ares Trading S.A. (S.R.), Eysins, Switzerland (an affiliate of Merck KGaA, Darmstadt, Germany).ORCID 0000-0002-7548-229X
MAGNIFY-MS Study Group
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThe onset of action for high-efficacy immunotherapies in multiple sclerosis (MS) is an important parameter. This study (MAGNIFY-MS) evaluates the onset of action of cladribine tablets by observing changes in combined unique active (CUA) MRI lesion counts during the first 6 months of treatment in patients with highly active relapsing MS.
methodsMRI was performed at screening, baseline, and at months 1, 2, 3, and 6 after initiating treatment with cladribine tablets 3.5 mg/kg. CUA lesion counts, defined as the sum of T1 gadolinium-enhancing (Gd+) lesions and new or enlarging active T2 lesions (without T1 Gd+), were compared between postbaseline and the baseline period and standardized to the period length and the number of MRIs performed.
resultsIncluded in this analysis were 270 patients who received ≥1 dose of cladribine tablets. After treatment initiation, significant reductions in mean CUA lesion counts were observed from month 1 onward compared with the baseline period (-1.193 between month 1 and month 6, -1.500 between month 2 and month 6, and -1.692 between month 3 and month 6; all DISCUSSION: Findings suggest an early onset of action for cladribine tablets, with an increasing reduction in active MRI lesions over time. TRIAL REGISTRATION INFORMATION: NCT03364036; Date registered: December 06, 2017. CLASSIFICATION OF EVIDENCE: Using frequent MRI assessments of the brain over the first 6 months of the MAGNIFY-MS study (NCT03364036), we aimed to determine the onset of action of cladribine tablets 3.5 mg/kg in adult patients with highly active relapsing MS. This study provides Class IV evidence that, in such patients, treatment with cladribine tablets is associated with an early onset of action with reductions in active MRI lesion counts from month 2 (day 60) onward, with an increasing reduction in such lesions over time.
Indexed as
CladribineMultiple SclerosisAdultHumansImmunosuppressive AgentsMagnetic Resonance ImagingTabletsCladribineImmunosuppressive AgentsTablets
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Registered trials
NCT03364036ClinicalTrials.gov
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