Evidence map›Paper›PMID 35701132›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2022

[Characteristics of amino acid metabolism in myeloid-derived suppressor cells in septic mice].

Y Ma, Y Zhang, R Li, S W Deng, Q S Qin, L L Zhu

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Risk factors of ICU-acquired weakness in sepsis patients.Pakistan journal of medical sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Y MaInstitute of Infectious Diseases, Peking University Ditan Teaching Hospital, Beijing 100015, China.
Y ZhangInstitute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
R LiInstitute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
S W DengInstitute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
Q S QinInstitute of Infectious Diseases, Peking University Ditan Teaching Hospital, Beijing 100015, China.
L L ZhuInstitute of Infectious Diseases, Peking University Ditan Teaching Hospital, Beijing 100015, China.
Capital Medical University · CNPeking University · CNBeijing Ditan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the amino acid metabolomics characteristics of myeloid-derived suppressor cells (MDSCs) in mice with sepsis induced by the cecal ligation and puncture (CLP).

methodsThe sepsis mouse model was prepared by CLP, and the mice were randomly divided into a sham operation group (sham group,

resultsThe proportion of MDSCs in the bone marrow of CLP group mice (75.53% ± 6.02%) was significantly greater than that of the sham group (43.15%± 7.42%,

conclusionThe enhanced mitochondrial oxidative phosphorylation, malate-aspartate shuttle and alanine metabolism in MDSCs of CLP mice may provide raw materials for mitochondrial aerobic respiration, thereby promoting the immunosuppressive function of MDSCs. Blocking the above metabolic pathways may reduce the risk of secondary infection in sepsis and improve the prognosis.

Indexed as

Myeloid-Derived Suppressor CellsSepsisAdenosine TriphosphateAlanineAnimalsAspartic AcidBiomarkersChromatography, LiquidGlycineMalatesMiceTandem Mass SpectrometryAdenosine TriphosphateAlanineAspartic AcidBiomarkersGlycineMalatesAerobic respirationAmino acid metabolomicsMyeloid-derived suppressor cellSepsis

Identifiers

PMID35701132
PMCPMC9197707
OpenAlexW4282979766

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.