Evidence map›Paper›PMID 35700904›Full record

ArticleOsteoarthritis and cartilage2022

Depressive symptoms and multi-joint pain partially mediate the relationship between obesity and opioid use in people with knee osteoarthritis.

L C Carlesso, S R Jafarzadeh, A Stokes, D T Felson, N Wang, L Frey-Law, C E Lewis, M Nevitt, T Neogi, Multicenter Osteoarthritis Study Group

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

L C CarlessoSchool of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada. Electronic address: carlesl@mcmaster.ca.
S R JafarzadehBoston University School of Medicine, Boston, MA, USA. Electronic address: srjafarz@bu.edu.
A StokesBoston University School of Public Health, Boston, MA, USA. Electronic address: acstokes@bu.edu.
D T FelsonBoston University School of Medicine, Boston, MA, USA. Electronic address: dfelson@bu.edu.
N WangBiostatistics and Epidemiology Data Analytics Center (BEDAC), Boston University School of Public Health, Boston, MA, USA. Electronic address: nwang10@bu.edu.
L Frey-LawDepartment of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, Iowa, USA. Electronic address: laura-freylaw@uiowa.edu.
C E LewisDepartment of Epidemiology, University of Alabama at Birmingham, School of Public Health, Birmingham, AL, USA. Electronic address: celewis@uabmc.edu.
M NevittUniversity of California, San Francisco, CA, USA. Electronic address: mnevitt@psg.ucsf.edu.
T NeogiBoston University School of Medicine, Boston, MA, USA. Electronic address: tneogi@bu.edu.
Multicenter Osteoarthritis Study Group
Boston University · USMcMaster University · CAUniversity of Alabama at Birmingham · USUniversity of California, San Francisco · USUniversity of Iowa · US

Funding

Multicenter Osteoarthritis Study (MOST) Second RenewalU01AG019069 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NEVITT, MICHAEL C · 2001 to 2020
$21.7M
Multicenter Osteoarthritis Study (MOST) Second Renewal: Iowa Clinical CenterU01AG018832 · NIA · UNIVERSITY OF IOWA · PI SEGAL, NEIL A, TORNER, JAMES C · 2001 to 2020
$14.1M
Multicenter Osteoarthritis Study (MOST) Second Renewal - Boston UniversityU01AG018820 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FELSON, DAVID TOBIN · 2001 to 2019
$13.6M
Multicenter Osteoarthritis Study (MOST) Second Renewal - UAB Clinical CenterU01AG018947 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEWIS, CORA E · 2001 to 2020
$13.2M
Research and Evaluation Support Core Unit (RESCU Core)P30AR072571 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TUHINA NEOGI · 2019 to 2026
$6.9M
PRROPS: Pathways of Risk and Resilience for Overlapping Pain and SensitizationR01NS121419 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Emelia J. Benjamin, ROBERT R EDWARDS · 2021 to 2026
$3.7M
CAPSITE: Community Assessment of Pain and Sensitization in the ElderlyR01AG066010 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., EDWARDS, ROBERT R · 2020 to 2025
$3.3M
Pain in community-based older African American Adults: The Jackson Heart StudyR01AG066914 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., EDWARDS, ROBERT R · 2020 to 2024
$3.2M
Unruptured Intracranial Aneurysms: Neurologic OutcomeR01NS048597 · NINDS · UNIVERSITY OF IOWA · PI TORNER, JAMES C · 2004 to 2007
$1.9M
The Role of Urate in Knee Osteoarthritis-Related Inflammation, Pathology and PainK24AR070892 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TUHINA NEOGI · 2017 to 2026
$1.1M
Dynamic Treatment Regimens of Physical Activity for Persons with OsteoarthritisR21AR074578 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI JAFARZADEH, S. REZA · 2019 to 2020
$411k
Effects of NSAIDs and non-NSAID Analgesics on Osteoarthritis OutcomesR03AG060272 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI JAFARZADEH, S. REZA · 2018 to 2019
$165k
NIAMS NIH HHS K24 AR070892NIAMS NIH HHS P30 AR072571NIAMS NIH HHS R21 AR074578NIA NIH HHS R01 AG066010NIA NIH HHS R01 AG066914NIA NIH HHS R03 AG060272NIA NIH HHS U01 AG018820NIA NIH HHS U01 AG018832NIA NIH HHS U01 AG018947NIA NIH HHS U01 AG019069NINDS NIH HHS R01 NS048597NINDS NIH HHS R01 NS121419
6 · The paper itself

Abstract

objectivesTo assess the relation of obesity to opioid use in people with or at risk of knee osteoarthritis (OA), and the extent to which this association is mediated by number of painful joints or depressive symptoms.

methodsWe used data from the Multicenter Osteoarthritis Study, a longitudinal cohort of older adults with or at risk of knee OA. Opioid use was identified by prescription medications and self-report. Obesity was defined as BMI ≥ 30 kg/m

resultsWe studied 2,335 participants (mean age: 68; mean BMI 31 kg/m

conclusionsMulti-joint pain and depressive symptoms partially explained greater opioid use among obese persons with knee OA, demonstrating that the negative impact of obesity on knee OA extends beyond its influence on knee pain and structural progression.

Indexed as

Osteoarthritis, KneeAgedAnalgesics, OpioidArthralgiaDepressionFemaleHumansMaleObesityRisk FactorsAnalgesics, OpioidDepressionKnee osteoarthritisMediation analysisObesity

Identifiers

PMID35700904
PMCPMC9419857
OpenAlexW4281816172

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.