ArticleImmunity2022
Genetic tracing reveals transcription factor Foxp3-dependent and Foxp3-independent functionality of peripherally induced Treg cells.
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Article in Immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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61citing papers in PubMed
6.3field-weighted citation impact, top 2% of its field
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Who cites it
61 citing papers in PubMed, 80 citations in OpenAlex.
- Regulatory T cell induction strategies and applications in the treatment of immune and non-immune diseases.Signal transduction and targeted therapy · 2026Review
- Mucosal immunity: mechanism and application in cancer immunotherapy.Journal of hematology & oncology · 2026Review
- Proteomic Insights Into Human Induced Regulatory T Cells: The Role of LPXN and CD160 in Immune Suppression.Molecular & cellular proteomics : MCP · 2026Article
- Article
- CNS1-dependent regulatory T cells shape recovery from acute lung injury.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Clonal embeddings allow exploratory analysis of lineage-resolved single-cell data.bioRxiv : the preprint server for biology · 2026Article
- [Research Progress of Peripheral Immune Tolerance in Oral Diseases].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- Role of solute carrier family 7 member 7 in cancer: opportunities for tumor microenvironment research.Journal for immunotherapy of cancer · 2026Review
- Bushen Huoxue Recipe enhances the immune microenvironment at the maternal-fetal interface via the Hippo signaling pathway in mice with recurrent spontaneous abortion.Journal of traditional and complementary medicine · 2026Article
- Insights into the mechanisms of drug resistance in renal cell carcinoma: from multi-omics perspective.International journal of surgery (London, England) · 2026Article
- REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis.The Journal of experimental medicine · 2026Article
- Defining nature, responses and drivers of regulatory- and conventional CD4Frontiers in immunology · 2026Article
- The immune anatomy of the small intestine facilitates regulatory responses.Frontiers in immunology · 2026Review
- The relativity of regulatory T cell suppression modes.Frontiers in immunology · 2026Review
- Decoding Treg diversity and dysfunction to advance Treg-based therapies in autoimmune and inflammatory diseases.Frontiers in immunology · 2026Review
- Context-dependent roles of the gut microbiome in food allergy tolerance versus sensitization.Gut microbes · 2025Review
- Regulatory roles of intestinal CD4Gut microbes · 2025Review
- Antigen-presenting cells as arbiters of mucosal tolerance and immunity.Nature immunology · 2025Review
- Tregs epigenetically reprogrammed from autoreactive effector T cells mitigate established autoimmunity.JCI insight · 2025Article
- A wave of Thetis cells imparts tolerance to food antigens early in life.Science (New York, N.Y.) · 2025Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Joris van der VeekenHoward Hughes Medical Institute and Immunology Program, Sloan Kettering Institute, and Ludwig Center at Memorial Sloan Kettering Cancer Center, New York, NY, USA; Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria. Electronic address: joris.van.der.veeken@imp.ac.at.
Clarissa CampbellHoward Hughes Medical Institute and Immunology Program, Sloan Kettering Institute, and Ludwig Center at Memorial Sloan Kettering Cancer Center, New York, NY, USA; CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Yuri PritykinLewis-Sigler Institute for Integrative Genomics and Computer Science Department, Princeton University, Princeton, NJ, USA.
Michail SchizasHoward Hughes Medical Institute and Immunology Program, Sloan Kettering Institute, and Ludwig Center at Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jacob VerterHoward Hughes Medical Institute and Immunology Program, Sloan Kettering Institute, and Ludwig Center at Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Wei HuHoward Hughes Medical Institute and Immunology Program, Sloan Kettering Institute, and Ludwig Center at Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Zhong-Min WangHoward Hughes Medical Institute and Immunology Program, Sloan Kettering Institute, and Ludwig Center at Memorial Sloan Kettering Cancer Center, New York, NY, USA; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Fanny MatheisLaboratory of Mucosal Immunology, The Rockefeller University, New York, NY, USA.
Daniel MucidaLaboratory of Mucosal Immunology, The Rockefeller University, New York, NY, USA.
Louis-Marie CharbonnierDepartment of Pediatrics, Harvard Medical School, Boston, MA, USA.
Talal A ChatilaDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.
Alexander Y RudenskyHoward Hughes Medical Institute and Immunology Program, Sloan Kettering Institute, and Ludwig Center at Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: rudenska@mskcc.org.
Memorial Sloan Kettering Cancer Center · USRockefeller University · USBoston Children's Hospital · USHarvard University · USPrinceton University · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MTumor-specific T cell state dynamics and heterogeneity in early tumorigenesisU54CA209975 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LESLIE, CHRISTINA S, RUDENSKY, ALEXANDER Y · 2016 to 2021
$11.8MSELF PEPTIDES BOUND TO MHC CLASS II IN T CELL SELECTIONR01AI034206 · NIAID · UNIVERSITY OF WASHINGTON · PI Alexander Y Rudensky · 1998 to 2026
$6.4MImmunological and Microbial Mechanisms in Food AllergyR01AI126915 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI Talal Amine Chatila, Seth Rakoff-Nahoum · 2017 to 2026
$4.9MReprogramming of Regulatory T cells to Promote Immune ToleranceR01AI153174 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI CHARBONNIER, LOUIS-MARIE · 2020 to 2024
$2.2MNCI NIH HHS P30 CA008748NCI NIH HHS U54 CA209975NIAID NIH HHS R01 AI034206NIAID NIH HHS R01 AI126915NIAID NIH HHS R01 AI153174
Abstract
Regulatory T (Treg) cells expressing the transcription factor Foxp3 are an essential suppressive T cell lineage of dual origin: Foxp3 induction in thymocytes and mature CD4
Indexed as
Forkhead Transcription FactorsT-Lymphocytes, RegulatoryImmune ToleranceTh17 CellsThymocytesForkhead Transcription FactorsFoxp3lineage tracingmicrobiotaperipherally induced TregTreg
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.