Evidence map›Paper›PMID 35700737›Full record

ArticleNeuron2022

Single-cell activity and network properties of dorsal raphe nucleus serotonin neurons during emotionally salient behaviors.

Grace E Paquelet, Kassandra Carrion, Clay O Lacefield, Pengcheng Zhou, René Hen, Bradley R Miller

Abstract read
In one paragraph

Article in Neuron, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed.

  1. Article
  2. Selective dysregulation of serotonin dynamics in the anterior cingulate cortex and central amygdala following binge alcohol consumption.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Grace E PaqueletDepartment of Neuroscience, Columbia University, New York, NY 10032, USA.
Kassandra CarrionDivision of Systems Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA.
Clay O LacefieldDivision of Systems Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA; Department of Psychiatry, Columbia University Medical Center, New York, NY 10032, USA.
Pengcheng ZhouDepartment of Neuroscience, Columbia University, New York, NY 10032, USA; Department of Statistics, Columbia University, New York, NY 10027, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027.
René HenDepartment of Neuroscience, Columbia University, New York, NY 10032, USA; Division of Systems Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA; Department of Psychiatry, Columbia University Medical Center, New York, NY 10032, USA.
Bradley R MillerDivision of Systems Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA; Department of Psychiatry, Columbia University Medical Center, New York, NY 10032, USA. Electronic address: bradley.miller@nyspi.columbia.edu.

Funding

Research Training in Mood and Anxiety Disorders: From Animal Models to PatientsT32MH015144 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Eduardo David Leonardo · 1985 to 2026
$11.1M
Circuits underlying overgeneralizationR01MH068542 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI Rene Hen · 2003 to 2026
$5.7M
Mapping Serotonergic Activity During Emotional Behaviors in the Healthy and Stressed BrainK08MH116368 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MILLER, BRADLEY · 2018 to 2020
$596k
NIMH NIH HHS K08 MH116368NIMH NIH HHS R01 MH068542NIMH NIH HHS T32 MH015144
6 · The paper itself

Abstract

The serotonin system modulates a wide variety of emotional behaviors and states, including reward processing, anxiety, and social interaction. To reveal the underlying patterns of neural activity, we visualized serotonergic neurons in the dorsal raphe nucleus (DRN

Indexed as

Dorsal Raphe NucleusSerotoninAnimalsMiceRewardSerotonergic NeuronsVentral Tegmental AreaSerotoninbed nucleus of the stria terminalisBNSTcalcium imagingdorsal raphe nucleusDRNmicroendoscopysalienceserotoninventral tegmental areaVTA

Identifiers

PMID35700737
PMCPMC9575686

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.